E2F2

Last update 08 May 2025

Basic Info

Synonyms

E2F transcription factor 2, E2F-2, E2F2

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Introduction

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

100 Clinical Results associated with E2F2

100 Translational Medicine associated with E2F2

0 Patents (Medical) associated with E2F2

619

Literatures (Medical) associated with E2F2

01 Apr 2025·Cytotechnology

E2F2 induces microglial activation and augments depressive-like behavior in mice by repressing PTPN6 transcription

Article

Author: Zhang, Leijing ; Ma, Lan ; Chen, Yao ; Xin, Jiali

Depression is the leading contributor to disability and suicide ideation. Informed by the insights from bioinformatics analyses, this study investigates the roles of E2F transcription factor 2 (E2F2) and protein tyrosine phosphatase non-receptor type 6 (PTPN6) in the activation of microglia and the manifestation of depressive-like behavior in mice. Chronic unpredictable mild stress was applied to induce a mouse model of depression, while a cellular model featuring microglia was established through exposure to lipopolysaccharide and adenosine triphosphate. E2F2 was upregulated whereas PTPN6 was downregulated in these models. Notably, E2F2 was found to bind to the PTPN6 promoter, thereby repressing its transcription. Various behavioral tests demonstrated that silencing of E2F2, accomplished via shRNA transfection, led to increased locomotor activity, heightened social interaction rates, enhanced sucrose preference, and reduced immobility time in response to stress stimuli in mice. Furthermore, E2F2 silencing effectively reduced expression of Iba1, a microglial activation marker, and decreased concentrations of pro-inflammatory cytokines both in vivo and in vitro. However, these mitigating effects were countered by additional PTPN6 silencing. In conclusion, this study investigation underscores the role of E2F2 in promoting inflammatory activation of microglia and exacerbating depressive-like behavior in mice by repressing PTPN6 transcription.

01 Apr 2025·Advanced Science

Correction to “[E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis]”

01 Feb 2025·Journal of Cellular and Molecular Medicine

MATN1‐AS1 Promotes Tumour Metastasis and Sunitinib Resistance via E2F2 in Clear Cell Renal Cell Carcinoma

Article

Author: Li, Haolin ; Wang, Baojun ; Liang, Chaozhao ; Xu, Qili ; Fei, Mintian ; Gao, Yu ; Feng, Rui ; Xiao, Haibing

ABSTRACTIt has become increasingly recognised that MATN1‐AS1 is involved in multiple tumour development. The role of MATN1‐AS1 in clear cell renal cell carcinoma (ccRCC), however, is still largely unrecognised. This study investigated the molecular functions of MATN1‐AS1 in promoting ccRCC metastasis and sunitinib resistance. MATN1‐AS1 was found to be mainly located in the cytoplasm and was upregulated in ccRCC, and a positive association was seen between greater levels of MATN1‐AS1 expression and worse clinical outcomes. Downregulating MATN1‐AS1 significantly hindered cell proliferation, migration, invasion and epithelial‐mesenchymal transition (EMT). MATN1‐AS1 promoted tumour growth and metastasis in vivo. Mechanismly, MATN1‐AS1 targeted microRNA miR‐214‐5p, thereby upregulating E2F2 and promoting E2F2‐mediated EMT. We discovered that MATN1‐AS1 also promoted sunitinib resistance via E2F2 in vitro. Collectively, our research uncovered the protumor characteristics of MATN1‐AS1 and suggested it as a therapeutic target for reverse sunitinib resistance in ccRCC.

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E2F2

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