Viral core proteins

Last update 23 Jan 2025

Basic Info

Synonyms-

Introduction-

100 Clinical Results associated with Viral core proteins

100 Translational Medicine associated with Viral core proteins

0 Patents (Medical) associated with Viral core proteins

Literatures (Medical) associated with Viral core proteins

01 Feb 2022·Bioorganic & Medicinal Chemistry LettersQ4 · MEDICINE

Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines

Q4 · MEDICINE

Article

Author: Han, Hongwei ; Yin, Tongming ; Chen, Xingyu ; Yang, Yonghua ; Wen, Zhongling ; Luo, Yuelin ; Han, Mi ; Lin, Faxiang ; Hu, Jiabao ; Qi, Jinliang ; Lin, Hongyan ; He, Cong ; Yang, Minkai ; Yang, Rongwu

In this study, a series of novel shikonin N-benzyl matrinic acid ester derivatives (PMMB-299-PMMB-310) were synthesized and tested for their ability to inhibit the proliferation of cancer cells. Compared with shikonin and matrine, some of the ester derivatives were found to exhibit better anti-proliferative activity against seven different cancer cell lines, with less cytotoxicity toward non-cancerous cells. The strongest anti-proliferative activity was exhibited by PMMB-302, which had an IC₅₀ value of 2.71 μM against A549 cells. The compound caused cell cycle arrest in the G2/M phase and induced apoptosis. Effects on the expression of apoptosis-related molecules such as Bcl2, Bcl-XL, caspase-3, caspase-9 and FADD suggested that PMMB-302 has tumor suppressive roles in lung cancer cells. In addition, PMMB-302 inhibited expression of telomerase core proteins, dyskerin and NHP2, and telomerase reverse transcriptase RNA. Moreover, molecular docking of PMMB-302 was subsequently conducted to determine the probable binding mode with telomerase. Taken together, the results indicate that PMMB-302 acts as a tumor suppressor in lung cancer cells by negatively regulating telomerase expression.

04 Sep 2020·Science AdvancesQ1 · CROSS-FIELD

Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes

Q1 · CROSS-FIELD

ArticleOA

Author: Kalniņš, Gints ; Bogans, Jānis ; Liekniņa, Ilva ; Šišovs, Mihails ; Rūmnieks, Jānis ; Tārs, Kaspars ; Akopjana, Ināra

Capsid structures reveal a remarkable structural diversity among small bacterial RNA viruses.

15 Oct 1990·FEBS LettersQ3 · BIOLOGY

MAP 30: a new inhibitor of HIV‐1 infection and replication

Q3 · BIOLOGY

Article

Author: Sylvia Lee-Huang ; Philip L. Huang ; Peter L. Nara ; Paul L. Huang ; Peter Huang ; Hao-Chia Chen ; Hsiang-fu Kung ; Henry I. Huang

A new inhibitor of human immunodeficiency virus (HIV) has been isolated and purified to homogeneity from the seeds and fruits of the Momordica charantia. This compound, MAP 30 (Momordica Anti‐HIV Protein), is a basic protein of about 30 kDa. It exhibits dose‐dependent inhibition of cell‐free HIV‐1 infection and replication as measured by: (i) quantitative focal syncytium formation on CEM‐ss monolayers; (II) viral core protein p24 expression; and (iii) viral‐associated reverse transcriptase (RT) activity in HIV‐1 infected H9 cells. The doses required for 50% inhibition (ID50) in these assays were 0.83, 0.22 and 0.33 nM, respectively. No cytotoxic or cytostatic effects were found under the assay conditions. These data suggest that MAP 30 may be a useful therapeutic agent in the treatment of HIV‐1 infections. The sequence of the N‐terminal 44 amino acids of MAP 30 has been determined.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Viral core proteins

Basic Info

Related

Analysis