HSP90

PRESS RELEASE CHARM Therapeutics Announces Foundation of Scientific Advisory Board (SAB) LONDON – 19 March 2024 -- CHARM Therapeutics (“CHARM”, “The Company”), a 3D deep-learning research company discovering and developing transformational medicines, today announces the foundation of its Scientific Advisory Board (SAB) to provide expert insight and guidance to the Company on the optimal application of 3D deep learning, protein design and prediction in real world medicine. The newly formed Board is comprised of world-leading experts whose skillsets span 3D deep learning and protein structure prediction, drug discovery and oncology. These individuals have a deep understanding of CHARM and its strategic priorities and will work closely with the CHARM leadership team to further advance the Company's proprietary DragonFold platform. DragonFold is an end-to-end 3D deep learning protein-ligand co-folding technology designed for the discovery and development of small molecule therapeutics. This pioneering technology enables CHARM to target and develop treatments for previously hard-to-drug targets in cancer and other therapeutic areas. Laksh Aithani, Co-Founder, Chief Executive Officer and Board Member of CHARM Therapeutics, said:“As CHARM advances its 3D deep learning platform in discovery it’s critical to maintain aligned oversight of our priorities and keep abreast of this emerging field. The individuals who are founding our Scientific Advisory Board are world experts in the application of machine learning to medicine and will provide crucial expertise as we move forward in advancing our programs towards clinical development. I am delighted that CHARM will be guided by such experts and look forward to working closely with them." Founding members of CHARM’s SAB: David Baker, Ph.D. is a Scientific Co-Founder at CHARM and Chair of the SAB. He serves as the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, the Henrietta and Aubrey Davis Endowed Professor of Biochemistry, and an adjunct professor of Genome Sciences, Bioengineering, Chemical Engineering, Computer Science, and Physics at the University of Washington School of Medicine. David Baker has been leading the field of protein design and protein structure prediction for the last two decades, for which he received the 2021 Breakthrough Prize in Life Sciences. David has published over 600 peer-reviewed scientific papers and been awarded over 100 patents. David has also co-founded a number of biotechnology companies, including SANA Biotechnologies (NASDAQ: SANA), Lyell Immunopharma (NASDAQ: LYEL), and Icosavax (NASDAQ: ICVX; recently acquired by AstraZeneca). Professor Paul Workman is a leading cancer research scientist known for pioneering many innovative cancer drugs and personalised medicines targeted at specific molecular abnormalities, a strategy he terms 'drugging the cancer genome'. He introduced the 'Pharmacological Audit Trail', a method employing biomarkers for informed drug development decisions. His work has significantly contributed to understanding cancer-causing proteins, drug resistance mechanisms, and developing inhibitors for protein and lipid kinases, such as AKT and PI3 kinases, and also molecular chaperones like Hsp90. Paul has been instrumental in cancer drug discovery both in academia and the industry over the last 27 years, leading teams based on the non-profit, team science model. Notably, he directed the Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research (ICR) in London from 1997 to 2016, where he was pivotal in the discovery of 20 drug candidates, 12 of which entered clinical trials, including capivasertib which was approved for breast cancer. From 2014-21, Paul also served as Chief Executive and President of ICR. In addition, Paul was a Co-Founder of Chroma Therapeutics and Piramed Pharma, and he is Science Partner at Nextech Invest. He has won numerous awards and is a Fellow of the Royal Society and the American Association for the Advancement of Science. Professor Ryan Adams, Ph.D. is a Professor of Computer Science and Machine Learning Researcher at Princeton University. Ryan completed his Ph.D. in Physics under David MacKay at the University of Cambridge, where he was a Gates Cambridge Scholar and a member of St. John's College. From 2011 to 2016, he was an Assistant Professor at Harvard University in the School of Engineering and Applied Sciences. In 2015, Ryan sold the company he co-founded, Whetlab, to Twitter (now X) and spent three years in industry at Twitter and Google before joining the faculty at Princeton in 2018. Professor Adams received the Defence Advanced Research Projects Agency (DARPA) Young Faculty Award and the Alfred P. Sloan Fellowship. Professor John P. Cunningham, Ph.D. is an Associate Professor of Statistics and a Principal Investigator at Columbia University's Zuckerman Institute. His research focuses on machine learning and its application to both science and industry, particularly employing artificial intelligence tools to understand complex processes such as biological intelligence. Professor Cunningham's background includes postdoctoral work in the Machine Learning Group at the University of Cambridge, graduate studies in Electrical Engineering at Stanford University, and an undergraduate degree in Computer Science from Dartmouth College. He is affiliated with several centres at Columbia, including the Foundations of Data Science, the Grossman Center for the Statistics of Mind, and the Center for Theoretical Neuroscience. ENDS CHARM Therapeutics Laksh Aithani, Chief Executive Officer Phone +44 7933 185425 laksh@charmtx.com ICR Consilium Amber Fennell /Jessica Hodgson / Davide Salvi Phone: 44 (0)20 3709 5700 charm@consilium-comms.com About CHARM Therapeutics CHARM Therapeutics is discovering and developing small molecule medicines against difficult-to-drug targets with its proprietary 3D deep learning-enabled platform, DragonFold. Powered by the first high throughput protein-ligand co-folding algorithm and a world-class team of scientists and engineers, CHARM seeks to deliver innovative approaches to create life-changing therapies for patients. Cambridge and London-based CHARM has raised $70 million to date and is building an interdisciplinary and entrepreneurial team, combining leaders from the fields of AI and biotechnology. It is supported by high quality international investors including OrbiMed, F-Prime Capital, General Catalyst, Khosla Ventures, Bristol Myers Squibb, NVIDIA and grep -vc. For more information, please visit:

Moffitt’s preclinical findings strongly suggest PV-10 induces immunogenic cell death-associated immunogenicity in HPV-positive and HPV-negative HNSCC in vitro and in vivo KNOXVILLE, TN, March 07, 2024 (GLOBE NEWSWIRE) -- Provectus Biopharmaceuticals Inc. (“Provectus” or the “Company”) (OTCQB: PVCT) today announced that data from preclinical research on PV-10 (rose bengal sodium) for the treatments of human papillomavirus (“HPV”)-positive and HPV-negative head and neck squamous cell carcinoma (“HNSCC”) will be presented at the upcoming annual meeting of the American Association for Cancer Research (“AACR”), to be held April 5-10, 2024 in San Diego, California. The abstract, which was accepted for a poster presentation, is titled “PV 10 induces endoplasmic reticulum stress and autophagy, triggering immunogenic cell death and anti-tumor immunity in head and neck squamous cell carcinoma” (Abstract #6742, Topic Track: Immunology, Session: Vaccines, Antigens, and Antigen Presentation 2). The work underlying this poster presentation is part of research conducted by Christine Chung, M.D., Chair, Department of Head and Neck-Endocrine Oncology and Program Leader of Head and Neck Oncology and members of the Chung laboratory at Moffitt Cancer Center (“Moffitt”) in Tampa, Florida. According to Moffitt’s abstract, “…in vitro findings reveal that PV-10 induces cytotoxicity in both mEER and MTE-RAS cells. Notably, PV-10 promotes a significant increase in [reactive oxygen species], leading to an elevation in late apoptotic cells. Markers of immunogenic cell death (ICD), including a statistically significant increase in the release of damage-associated molecular pattern molecules HMGB1 and ATP, as well as enhanced surface expression of calreticulin, HSP-70, and HSP-90, were observed. At the molecular level, a remarkable activation of endoplasmic reticulum (ER) stress, pro-apoptotic protein, and autophagy markers were observed. Intratumoral PV-10 injection in vivo has shown significant tumor regression in both mEER and MTE-RAS tumors, and a complete response was noticed in some mice, indicating that PV-10 induces potent ICD in both mEER and MTE-RAS tumors.” About Provectus Provectus Biopharmaceuticals, Inc. is a clinical-stage biotechnology company developing immunotherapy medicines for different diseases that are based on a class of synthetic small molecule immuno-catalysts called halogenated xanthenes. Provectus’s lead HX molecule is named rose bengal sodium. Provectus’s medical science platform includes clinical development programs in oncology, dermatology, and ophthalmology; proof-of-concept in vivo development programs in oncology, hematology, full-thickness cutaneous wound healing, and canine cancers; and in vitro discovery programs in infectious diseases, tissue regeneration and repair, and proprietary targets. Information about the Company’s clinical trials can be found at the National Institutes of Health (NIH) registry, ClinicalTrials.gov. For additional information about Provectus, please visit the Company’s website at . FORWARD-LOOKING STATEMENTS: The information provided in this press release may include forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995, relating to the business of Provectus and its affiliates, which are based on currently available information and current assumptions, expectations, and projections about future events and are subject to a variety of risks and uncertainties and other factors that could cause actual events or results to differ materially from those projected in the forward-looking statements. Such statements are made in reliance on the safe harbor provisions of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are often, but not always, identified by the use of words such as “aim,” “likely,” “outlook,” “seek,” “anticipate,” “budget,” “plan,” “continue,” “estimate,” “expect,” “forecast,” “may,” “will,” “would,” “project,” “projection,” “predict,” “potential,” “targeting,” “intend,” “can,” “could,” “might,” “should,” “believe,” and similar words suggesting future outcomes or statements regarding an outlook. The safety and efficacy of Provectus’s drug agents and/or their uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated or that such agents as products will achieve any revenue levels. Due to the risks, uncertainties, and assumptions inherent in forward-looking statements, readers should not place undue reliance on these forward-looking statements. The forward-looking statements contained in this press release are made as of the date hereof or as of the date specifically specified herein, and the Company undertakes no obligation to update or revise any forward-looking statements, whether because of new information, future events, or otherwise, except in accordance with applicable securities laws. The forward-looking statements are expressly qualified by this cautionary statement. Risks, uncertainties, and assumptions include those discussed in the Company’s filings with the Securities and Exchange Commission, including those described in Item 1A of: The Company’s Annual Report on Form 10-K for the period ended December 31, 2022, and Provectus’s Quarterly Report on Form 10-Q for the period ended September 30, 2023. ##### Contact: Provectus Biopharmaceuticals, Inc. Heather Raines, CPA Chief Financial Officer Phone: (866) 594-5999

MC2 Therapeutics to Present at Upcoming Conferences Copenhagen, February 26th, 2024 – MC2 Therapeutics, a commercial stage biotech company focused on developing novel treatment paradigms within immunology and inflammation, announces today that its leadership will attend and present at the following industry conferences: 17th Annual European Life Sciences CEO Forum, Zürich February 28th-29th (presentation at 3:20pm CET, February 28th - Track C - Room Panorama C)TD Cowen Annual Health Care Conference, Boston March 4th-6th (hosting 1:1 meetings with investors on March 4th at the event)American Academy of Dermatology Annual Meeting, San Diego March 8th-12thKempen Life Science Conference, Amsterdam April 16th-17th (presentation on April 16th)Bio€quity Europe, San Sebastian May 12th-14th (presentation time and location to be announced) Any webcasts will be available on MC2’s website following the presentations. Please contact us if you would like to arrange a meeting. About MC2 TherapeuticsMC2 Therapeutics is a commercial stage biotech company focused on developing novel treatment paradigms within immunology and inflammation. Its pioneering approach in immunology is anchored in a deep understanding of skin biology, clinical expertise and cross-silo thinking. Its pipeline includes two first-in-class drug candidates both in Phase 2 clinical development, with novel modes of action and blockbuster potential in multiple indications (“I&I pipeline in a product”): MC2-32: an oral HSP90 inhibitor with unique tissue specific targeting and a new MOA that modulates multiple pro-inflammatory pathways and relevant immune responses.MC2-25: an iso-cyanate scavenger addressing carbamylation of proteins and amino acids in the skin by iso-cyanate, a dissociation product of urea. For additional information on MC2 Therapeutics, please visit www.mc2therapeutics.com.Contacts:Lonni Goltermann, +45 2018 1111, investor@mc2therapeutics.com Media: ICR ConsiliumAmber Fennell, +44 20 3709 5700, MC2@consilium-comms.com