Last update 01 Nov 2024

EF-1A

Last update 01 Nov 2024

Basic Info

Synonyms

DKFZp434g247, EF-1a, eRF3c

+ [7]

Introduction

GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463).

Drugs associated with EF-1A

FFT-135

Target

EF-1A x GSPT1 x GSPT2

Mechanism

EF-1A degraders [+2]

Active Org.

F5 Therapeutics, Inc.Startup

Originator Org.

F5 Therapeutics, Inc.Startup

Active Indication

Colorectal Cancer [+2]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with EF-1A

100 Translational Medicine associated with EF-1A

0 Patents (Medical) associated with EF-1A

737

Literatures (Medical) associated with EF-1A

01 Jan 2025·Food Chemistry

Transcriptome analysis reveals the potential mechanism of methyl jasmonate alleviated ripening disorder in mango fruit at low temperature

Article

Author: Zhu, Lisha ; Liu, Jialiang ; Zhang, Zhengke ; Xu, Xiangbin ; Huang, Ting

High susceptibility of mangoes to low temperature leads to ripening failure that restricts the marketability of products. This study investigated the effect of methyl jasmonate (MeJA) on ripening disorder and mechanism involved in mangoes during refrigeration. Results showed that 50 μM MeJA ameliorated ripening disorder, as indicated by accelerated advancement of ripening-related parameters. Transcriptome analysis revealed that 17,414 significantly differentially expressed genes were mainly enriched in ethylene synthesis, cell wall degradation, starch degradation and sugar transport. Moreover, 8 AP2/ERF transcription factors and 12 ripening-related genes were characterized via qRT-PCR. Afterwards, through the analysis of transcription factor binding sites and cis-acting elements, a regulatory network of ERFs mediated alleviation of ripening disorder conferred by MeJA was constructed. Finally, the interactions between MiERFs and the promoters of target genes were verified by yeast one-hybrid assay. Our findings provide a theoretical basis for improving cold tolerance via counteracting ripening disorder in mangoes.

30 Oct 2024·Journal of Experimental Botany

Combined transcriptome and metabolome analysis identifies triterpenoid-induced defense responses in Myzus persicae Sülzer-infested peach

Article

Author: Huang, Rui ; Cui, Guochao ; Sun, Shihang ; Duan, Wenyi ; Niu, Liang ; Lu, Zhenhua ; Pan, Lei ; Zeng, Wenfang ; Wang, Zhiqiang ; Yan, Lele

AbstractPiercing/sucking insects such as green peach aphid (GPA) (Myzus persicae) cause direct damage by obtaining phloem nutrients and indirect damage by spreading plant viruses. To investigate the response of peach trees (Prunus persica) to aphids, the leaf transcriptome and metabolome of two genotypes with different sensitivities to GPA were studied. The gene expression of aphid-susceptible plants infested with aphids was similar to that of control plants, whereas the gene expression of aphid-resistant plants infested with aphids showed strong induced changes in gene expression compared with control plants. Furthermore, gene transcripts in defense-related pathways, including plant–pathogen interaction, MAPK signaling, and several metabolic pathways, were strongly enriched upon aphid infestation. Untargeted secondary metabolite profiling confirmed that aphid infestation induced larger changes in aphid-resistant than in aphid-susceptible peaches. Consistent with transcriptomic alterations, nine triterpenoids showed highly significant GPA-induced accumulation in aphid-resistant peaches, whereas triterpenoid abundance remained predominantly unchanged or undetected in aphid-susceptible peaches. Furthermore, some types of transcription factors (including WRKYs, ERFs, and NACs) were strongly induced upon GPA infestation in aphid-resistant, but not in aphid-susceptible peaches. These results suggested that the accumulation of specialized triterpenoids and the corresponding pathway transcripts may play a key role in peach GPA resistance.

01 Oct 2024·New Phytologist

The StPti5 ethylene response factor acts as a susceptibility factor by negatively regulating the potato immune response to pathogens

Article

Author: Stare, Katja ; Coll, Anna ; Baebler, Špela ; Mahkovec Povalej, Tjaša ; Coll, Núria Sánchez ; Lukan, Tjaša ; Zagorščak, Maja ; Petek, Marko ; Prat, Salomé ; Gruden, Kristina ; Valls, Marc

Summary

Ethylene response factors (ERFs) have been associated with biotic stress in Arabidopsis, while their function in non‐model plants is still poorly understood. Here we investigated the role of potato ERF StPti5 in plant immunity.

We show that StPti5 acts as a susceptibility factor. It negatively regulates potato immunity against potato virus Y and Ralstonia solanacearum, pathogens with completely different modes of action, and thereby has a different role than its orthologue in tomato. Remarkably, StPti5 is destabilised in healthy plants via the autophagy pathway and accumulates exclusively in the nucleus upon infection. We demonstrate that StEIN3 and StEIL1 directly bind the StPti5 promoter and activate its expression, while synergistic activity of the ethylene and salicylic acid pathways is required for regulated StPti expression.

To gain further insight into the mode of StPti5 action in attenuating potato defence responses, we investigated transcriptional changes in salicylic acid deficient potato lines with silenced StPti5 expression. We show that StPti5 regulates the expression of other ERFs and downregulates the ubiquitin‐proteasome pathway as well as several proteases involved in directed proteolysis.

This study adds a novel element to the complex puzzle of immune regulation, by deciphering a two‐level regulation of ERF transcription factor activity in response to pathogens.

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EF-1A

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