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Last update 08 May 2025

ANAPC1

Last update 08 May 2025

Basic Info

Synonyms

ANAPC1, anaphase promoting complex subunit 1, Anaphase-promoting complex subunit 1

+ [6]

Introduction

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132).

Drugs associated with ANAPC1

APC1 (TwoToBiotech)

Target

ANAPC1 x INSR

Mechanism

ANAPC1 modulators [+1]

Active Org.

TwoToBiotech

Originator Org.

TwoToBiotech

Active Indication

Diabetes Mellitus, Type 2

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with ANAPC1

100 Translational Medicine associated with ANAPC1

0 Patents (Medical) associated with ANAPC1

Literatures (Medical) associated with ANAPC1

31 Dec 2025·Future Science OA

Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms

Article

Author: Chi, Bang-Teng ; Wei, Yue ; Song, Chang ; Zhao, Chun-Yan ; He, Shu-Jia ; Lu, Hui-Ping ; Chen, Gang ; Kong, Jin-Liang ; He, Rong-Quan ; Huang, Wan-Ying ; Chen, Xiao-Song ; Chen, Yi-Yang ; Chen, Feng

AIMTo investigate the comprehensive expression levels and possible molecular mechanisms of Anaphase Promoting Complex Subunit 1 (ANAPC1) in lung squamous cell carcinoma (LUSC).METHODSData from 2,031 samples were combined to evaluate ANAPC1 mRNA levels, and 118 samples were collected for immunohistochemical (IHC) analysis. High-expression co-expressed genes (HECEGs) associated with ANAPC1 were analyzed for signaling pathways. Clinical significance, immune computations, and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) validation of ANAPC1's role in LUSC were assessed. Molecular docking evaluated binding affinity with potential therapeutics.RESULTSANAPC1 mRNA was significantly upregulated in LUSC (SMD = 1.97, 95% CI [1.26-2.67]). Protein-level analysis confirmed this upregulation (p < 0.001). Most HECEGs associated with ANAPC1 were enriched in cell cycle pathways. Higher ANAPC1 expression correlated with poorer survival in LUSC patients (HR = 1.11, 95% CI: 1-1.49). ANAPC1 expression was higher in males and N1-stage vs. females and N0-stage; lower in grade I vs. II/III. Overexpression reduces immune cell infiltration and immunotherapy effectiveness, while knockdown inhibits cell proliferation. Drug sensitivity and docking analyses identified tenovin-1, carboxyatractyloside, and phycocyanobilin as potential antitumor agents targeting ANAPC1.CONCLUSIONThe elevated expression of ANAPC1 might play a role in LUSC advancement and progression through its participation in cell growth-related pathways.

01 Apr 2025·Cancer Genetics

RECQL4-related Rothmund-Thomson syndrome: A case series and literature review

Review

Author: Cheng, Shirley Sze Wing ; Fu, Eric Chun Ho ; Liu, Anthony Pak Yin ; Ho, Stephanie Ka Lun ; Tong, Grace Pui Yung ; Leung, Lai-Ting ; Lo, Ivan Fai Man ; Luk, Ho-Ming

Rothmund-Thomson syndrome (RTS) is a multisystemic tumour-predisposing genodermatosis caused by biallelic pathogenic alterations in the ANAPC1 gene or RECQL4 gene. Herein we describe the clinical and genetic findings in three individuals with molecularly substantiated RECQL4-related RTS. Based on the disease course of two patients with osteosarcoma, we highlight the critical importance of early diagnosis.

01 Mar 2025·Cancer Control

The Potential Biological Roles and Clinical Significance of Anaphase-Promoting Complex Subunit 1 in Colorectal Cancer

Article

Author: Wei, Qiu-Yu ; He, Rong-Quan ; Zhan, Yan-Ting ; Chen, Yi ; Chen, Gang ; Li, Hui ; Li, Dong-Ming ; Wen, Jia-Ying ; Tang, Yu-Lu ; Chen, Yu-Zhen ; Huang, Zhi-Guang ; Tang, Yu-Xing ; Zeng, Da-Tong

BackgroundAnaphase-promoting complex subunit 1 (ANAPC1) is a regulator of cellular mitosis and an important factor in tumorigenesis. To date, a comprehensive assessment of the potential role, biological behaviours, and clinical significance of ANAPC1 in colorectal cancer (CRC) is still lacking.Materials and methodsThis study integrated 2329 mRNA expression data, single-cell RNA sequencing (scRNA-seq), and internal immunohistochemistry of 416 tissue samples to comprehensively evaluate the abnormal expression pattern of ANAPC1 in CRC. It also incorporated evidence from immune infiltration analysis, functional enrichment analysis, and weighted gene co-expression network analysis to explore the biological behaviour of ANAPC1 in CRC. In addition, in vitro cell biology experiments such as real-time polymerase chain reaction (RT-PCR), western blot (WB), cholecystokinin 8 (CCK-8), wound healing, cell cycle, and apoptosis assays were conducted to verify the potential effect of ANAPC1 on CRC cells.Results ANAPC1 mRNA was significantly overexpressed in CRC tissue (SMD = 2.07, 95% CI 1.59-2.55, P < .05) and malignant epithelial cells ( P < .05). Validation at the protein level similarly confirmed the overexpression of ANAPC1 in CRC tissue ( P < .05). ANAPC1 in CRC may play a role in abnormal ribosome biogenesis, DNA replication, ATP-dependent activity acting on DNA, nuclear division, chromosome segregation, and other pathways. In vitro experiments demonstrated that HCT-116 cells with ANAPC1 knockdown had reduced proliferation and migration abilities, increased cell apoptosis rate, and altered cell cycle distribution. In addition, CRC patients with low ANAPC1 expression were more likely to benefit from treatment with immune checkpoint inhibitors. ANAPC1 was significantly downregulated in malignant epithelial cells of CRC treated with PD-1 inhibitors ( P < .05). ConclusionANAPC1 may have a positive impact on the development of CRC by being involved in pathways related to DNA replication, chromosome segregation, and ribosomes.

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ANAPC1

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