HMGCS1

Last update 08 May 2025

Basic Info

Synonyms

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl-CoA synthase 1

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Introduction

Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.

100 Clinical Results associated with HMGCS1

100 Translational Medicine associated with HMGCS1

0 Patents (Medical) associated with HMGCS1

2,414

Literatures (Medical) associated with HMGCS1

31 Dec 2025·Emerging Microbes & Infections

SREBP2-dependent lipid droplet formation enhances viral replication and deteriorates lung injury in mice following IAV infection

Article

Author: Dong, Hong ; Wang, Lige ; Hu, Yanxin ; Yang, Hanchun ; Su, Ruijing ; Tian, Jijing ; Zhou, Hongye ; Li, Yuli ; Sun, Jiali ; Xiao, Jin ; Li, Xinsen ; Li, Lu ; Sha, Shuhan ; Huo, Caiyun

Influenza A virus (IAV) is a significant zoonotic pathogen that poses a considerable challenge to public health due to its continuous mutations. Lipid droplets (LDs) have been shown to play an important role in the process of several viral infections. However, their role in IAV infection remains unclear. Here, we found that IAV infection altered the lipid metabolism and increased the content of LDs in the lungs of mice. In vitro, IAV infection also mediated the formation of LDs in A549 cells. Besides, inhibition of the formation of lipid droplets can significantly suppress IAV replication and the release of inflammatory factors, indicating that LDs could facilitate the virus replication and inflammatory response. Furthermore, we discovered that IAV infection could activate the SREBP2, a crucial lipid-regulating transcription factor that regulates the expressions of downstream proteins named HMGCR and HMGCS. HMGCR and HMGCS involved in the process of cholesterol synthesis, which further promoted the formation of LDs. Additionally, the use of fatostatin that specifically inhibits the maturation of SREBP2 was able to significantly suppress the viral replication of H5N1 in cells and effectively ameliorated IAV-induced lung injury in mice, which eventually promoted the survival rate of infected mice. Taken together, we demonstrate the essential roles of lipid metabolism and LD formation in IAV replication and pathogenesis, which may better facilitate the advancement of new strategies against IAV infection, especially the highly pathogenic H5N1 virus.

01 Jun 2025·Toxicology Reports

Effects of opium on cholesterol metabolism in rats fed normal and high-fat/high-cholesterol diet

Article

Author: Abbasi, Ebrahim ; Khodadadi, Iraj ; Shafiee, Gholamreza ; Ebrahimi, Elaheh

There is a misconception that opium can lower blood sugar and cholesterol levels. Hence, this study aimed to investigate the influences of opium on the expression of key cholesterol metabolism genes in the liver and intestine of rats receiving a cholesterol-rich diet. Male Wistar rats were randomly divided into four groups (n = 6): normal control, opium addiction, hypercholesterolemic diet, and opium addiction received hypercholesterolemic diet. After 28 days, the blood glucose levels, liver enzymes, and cholesterol in the rat's serum were measured. The cholesterol regulatory genes and transporters such as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, low-density lipoprotein receptor (LDL-R), cholesterol 7 alpha-hydroxylase 1 (CYP7A1) (in liver tissue), and ATP Binding cassette subfamily g member 5 and 8 (ABCG5 and ABCG8), and Niemann-Pick C1-like 1 protein (NPC1L1) (in intestinal tissue) were measured. Intestinal morphological changes were also evaluated. Opium decreased serum glucose and total cholesterol levels (P < 0.05). In contrast, the levels of liver enzymes increased compared to the normal control group (P < 0.05). Histological examinations revealed that opium caused disorganization, deformation, and destruction of cells in intestinal tissue. Real-time PCR analysis demonstrated that opium increased the expression of LDL receptor genes, HMG-CoA reductase enzyme, and CYP7A1 in the liver compared to the normal control group (P < 0.05). The changes of ABCG8 and NPC1L1 transporters in intestinal tissue were not significant. Opium had beneficial effects on blood lipid and glucose levels, but histological findings indicated destructive effects on intestinal tissues.

01 Jun 2025·Toxicology Reports

Fenofibrate ameliorated atorvastatin and piperine-induced ROS mediated reproductive toxicity in male Wistar rats

Article

Author: Sarkar, Sweata ; Biswas, Maharaj ; Ghosh, Sanjib

Atorvastatin and fenofibrate are well-known lipid-lowering drugs. Atorvastatin acts by reducing the production of cholesterol through the inhibition of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG Co-A reductase) enzyme, whereas fenofibrate is a PPAR-α agonist. Piperine is an alkaloid mostly found in black pepper fruits. The present study was planned to evaluate the activities of atorvastatin, fenofibrate, and piperine on the male reproductive system. A total of 35 male Wistar rats were obtained for the experiment. Rats were randomly divided into 7 groups, each group with 5 rats. The experiment was run for 28 days. Group I rat got normal meals for 28 days; Group II received atorvastatin (08 mg/kg/day); Group III received piperine (10 mg/kg/day); and Group IV received fenofibrate (20 mg/kg/day). Group V received atorvastatin (8 mg/kg/day) and piperine (10 mg/kg/day); Group VI received piperine (10 mg/kg/day) and fenofibrate (20 mg/kg/day). VII received fenofibrate (20 mg/kg bw/day) and atorvastatin (8 mg/kg/day). After sacrifice, serum and testicular cholesterol and testosterone levels assessed by ELISA, ROS generation analysed by using flow cytometry, MDA, SOD, and catalase were measured. Histological, sperm-parameter analysis, and spermatogenic evaluations were also done. Activities of atorvastatin and piperine revealed reproductive toxicity upon treatment. Fenofibrate treatment, along with atorvastatin and piperine, showed protective effects. In conclusion, atorvastatin and piperine affected reproductive potential, whereas fenofibrate might have protective efficacy against atorvastatin and piperine-induced reproductive toxicity.

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HMGCS1

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