DFFB

Last update 23 Jan 2025

Basic Info

Synonyms

CAD, Caspase-activated deoxyribonuclease, Caspase-activated DNase

+ [8]

Introduction

Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.

100 Clinical Results associated with DFFB

100 Translational Medicine associated with DFFB

0 Patents (Medical) associated with DFFB

400

Literatures (Medical) associated with DFFB

01 Mar 2025·International Journal of Biological Macromolecules

Immunomodulatory lectin from Cordia myxa targets PI3K/AKT signalling mediated apoptosis to regress both in-vitro and in-vivo tumour

Article

Author: Prabhakar, B T ; Banumathi ; Sherapura, Ankith ; Siddesh, B M ; Kiran, B K ; Suchetha Kumari, N ; Mahmood, Riaz

Plant based medicine is gaining recognition as a complementary approach to conventional treatments. Plants contain lectins that bind to carbohydrates and exhibit various biological properties and being used in cancer treatment. In present investigation Cordia myxa fruit was chosen, screen for presence of lectin and explore its biological role. Screening of lectin was conducted through HA activity. Purification and characterization through conventional methods. HI assay to confirm the carbohydrate specificity. Immunomodulatory role by proliferative assays and ELISA. Apoptosis by annexin-V stain, TUNEL, MOMP and COMET assay and in-vivo antitumour activity by EAC induced ascites and solid tumour model. Gene expression through IB and IHC. The results illustrated that, presence of immunostimulant, ̴12 kDa lectin (CML) with strong leucoaggulutination activity having ovalbumin & fetuin specificity. The CML exhibits immune cell proliferation and secretes immune cytokines IL-2, IL-10 & IL-12. The immunomodulatory experiments infer that, CML induces anti-proliferative response against A549 and EAC by inducing apoptosis, which were validated in an in-vitro & in-vivo models. Mechanistically, CML modulates phosphorylation of PI3K/AKT signalling pathways and modulates downstream apoptotic proteins P53, Bax, Bad, Bcl-2, cytochrome-c, caspase-3 and DFF-40. Overall, the study reports the immunomodulatory lectin in Cordia myxa with its potential therapeutic role.

01 Oct 2024·Cell Reports

Destruction as a creative process: CAD-induced DNA strand breaks promote macrophage differentiation

Article

Author: Megeney, Lynn A ; Megeney, Lynn A. ; Alsowaida, Dalal

In a recent issue of Cell Reports, Maurya et al.¹ demonstrated that Drep4, the Drosophila homolog of caspase-activated DNase (CAD), drives DNA strand breaks during myeloid-like/macrophage cell differentiation and that this Drep4/CAD activity is essential for the differentiation process.

01 Jul 2024·Angewandte Chemie International Edition

In‐Situ Cyclized Polyacrylonitrile as an Electron Selective Layer for n‐i‐p Perovskite Solar Cell with Enhanced Efficiency and Stability

Article

Author: Yang, Lian‐Ming ; Gao, Cai‐Yan ; Song, Yanlin ; Jiang, Ke‐Jian ; Fan, Xin‐Heng ; Gu, Wei‐Min ; Jiao, Xinning

AbstractIn situ cyclized polyacrylonitrile (CPAN) is developed to replace n‐type metal oxide semiconductors (TiO2 or SnO2) as an electron selective layer (ESL) for highly efficient and stable n‐i‐p perovskite solar cells (PSCs). The CPAN layer is fabricated via facile in situ cyclization reaction of polyacrylonitrile (PAN) coated on a conducting glass substrate. The CPAN layer is robust and insoluble in common solvents, and possesses n‐type semiconductor properties with a high electron mobility of 4.13×10−3 cm2 V−1 s−1. With the CPAN as an ESL, the PSC affords a power conversion efficiency (PCE) of 23.12 %, which is the highest for the n‐i‐p PSCs with organic ESLs. Moreover, the device with the CPAN layer holds superior operational stability, maintaining over 90 % of their initial efficiency after 500 h continuous light soaking. These results confirm that the CPAN layer would be a desirable low‐cost and efficient ESL for n‐i‐p PSCs and other photoelectronic devices with high performance and stability.

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DFFB

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