Synonyms D(2C) dopamine receptor, D(4) dopamine receptor, D4DR + [3] |
Introduction Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). |
Mechanism 5-HT1A receptor agonists [+2] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date18 Aug 2015 |
Mechanism 5-HT1A receptor partial agonists [+6] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhasePhase 3 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Mechanism 5-HT2A receptor modulators [+1] |
Active Org. ANeuroTech BVStartup |
Originator Org. ANeuroTech BVStartup |
Active Indication |
Inactive Indication- |
Drug Highest PhasePhase 3 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date24 Jan 2022 |
Sponsor / Collaborator |
Start Date02 Jul 2021 |
Sponsor / Collaborator |
Start Date08 May 2020 |
Sponsor / Collaborator |