Synonyms Long transient receptor potential channel 6, LTrpC-6, LTrpC-6LTrpC6 + [7] |
Introduction Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. |
Target |
Mechanism TRPA1 agonists [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date20 Feb 2008 |
Mechanism COX inhibitors [+3] |
Active Org. |
Originator Org. |
Active Indication- |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. GB |
First Approval Date06 Aug 1998 |
Mechanism TRPA1 inhibitors [+2] |
Active Org. |
Originator Org. |
Active Indication- |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. JP |
First Approval Date20 Jan 1986 |
Start Date01 Mar 2025 |
Sponsor / Collaborator Yale University [+1] |
Start Date15 Jan 2025 |
Sponsor / Collaborator |
Start Date15 Oct 2024 |
Sponsor / Collaborator |