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Last update 08 May 2025

MIR129

Last update 08 May 2025

Basic Info

Synonyms

miR-129 family

Introduction-

Drugs associated with MIR129

US20240150765

Patent Mining

Target

MIR129 x MIR139 x MIR140 x MIR194 x miR-145 x miR-15a x miR-16 x miR-192

Mechanism-

Active Org.

Curamir Therapeutics, Inc.

Originator Org.

Curamir Therapeutics, Inc.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with MIR129

100 Translational Medicine associated with MIR129

0 Patents (Medical) associated with MIR129

319

Literatures (Medical) associated with MIR129

01 Jun 2025·Life Sciences

Intermittent hypoxia-reoxygenation-induced miRNAs inhibit expression of IRF and interferon genes but activate NF-κB and expression of pulmonary fibrosis markers in human small airway epithelial cells

Article

Author: Jheng, Cheng-Yu ; Lee, Yu-Chun ; Chen, Yi-Hui ; Chen, Shiuan-Ting ; Lee, Shih-Yu ; Huang, Wei-Chen

AIMIntermittent hypoxia-reoxygenation (H/R) has been demonstrated to be associated with aviation and various respiratory diseases, and hence it is of interest to unravel the regulatory mechanisms underlying the H/R-induced innate immune and inflammatory responses in both healthy and COPD-diseased human small airway epithelial cells (SAECs).MAIN METHODSThe normal healthy and COPD-diseased SAECs (i.e., N-SAECs and D-SAECs) were purchased from PromoCell biotechnology company and respectively cultured under normoxia (21 % O₂) or 12/12-h cycles of H/R (i.e., 1 % O₂ and 21 % O₂ alternately) for 6 days in total for 2D cultures and 21 days in total for the air-liquid interface 3D cultures, followed by qPCR analyses, miRNA fluorescence in situ hybridization, luciferase reporter assays, and immunofluorescence staining.KEY FINDINGSHuman SAECs cultured under 12/12-h cycles of H/R showed dramatically increased expression of HIF1A and the H/R-inducible miRNAs miR-129-1-3p, miR-1290 and miR-193b-5p, with miR-129-1-3p and miR-193b-5p targeting and inhibiting IRF5 and IRF7 mRNAs, hence downregulating both the type I and II interferon genes in SAECs cultured under H/R. In addition, miR-129-1-3p, miR-1290 and miR-193b-5p all targeted and inhibited SOCS3 mRNA, hence upregulating transactivation of NF-κB and in turn inducing expression of the inflammatory chemokine genes and pulmonary fibrosis-associated marker genes.SIGNIFICANCEWe show for the first time that intermittent H/R upregulates the NF-κB-induced proinflammatory and fibrosis marker genes whereas downregulates the IRF5/7-induced type I/II interferon expression in human SAECs through distinct HIF1A-inducible miRNAs miR-129-1-3p, miR-193b-5p and miR-1290, which may serve as promising therapeutic targets for airway inflammation and pulmonary fibrosis.

01 Mar 2025·International Journal of Biological Macromolecules

Decorin-mediated dermal papilla cell-derived exosomes regulate hair follicle growth and development through miR-129-2-3p/SMAD3/TGF-β axis

Article

Author: Chen, Yang ; Zhao, Bohao ; Wu, Xinsheng ; Bao, Zhiyuan ; Zheng, Feiyang ; Yu, Yongqi ; Li, Jiali ; Cai, Jiawei

Decorin (DCN) is a member of the small leucine-rich proteoglycan family within the extracellular matrix, playing a role in the growth and development of hair follicle (HF). Exosomes serve as significant mediators of intercellular communication and are involved in the cyclic regeneration of HF. Exosomes derived from dermal papilla cells (DPC-Exos) are essential for the cycling and regrowth of HF. The present study demonstrated that DCN treatment significantly enhances the proliferation of DPCs, thereby promoting hair follicle growth. miRNA sequencing revealed 442 differentially expressed exosomal miRNAs. The regulatory mechanism of exosomal miR-129-2-3p, an up-regulated differential miRNA, was further investigated. The study identified its role in transporting DPCs to HFSCs through DPC-Exos. miR-129-2-3p has been shown to suppress the expression of genes associated with HF growth and development, lower the expression of genes and proteins downstream of the TGF-β signaling pathway, promote HFSC proliferation, and decrease HFSC apoptosis. Furthermore, miR-129-2-3p displayed an antagonistic effect on activating the TGF-β/SMAD3 signaling pathway induced by SRI-011381. The findings indicate that DCN-mediated DPC-Exos influence HF growth and development through the miR-129-2-3p/SMAD3/TGF-β regulatory axis. These results may facilitate novel strategies for the diagnosis and treatment of human hair disorders, in addition to enhancing industrial wool production.

18 Feb 2025·British Journal of Dermatology

Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing

Article

Author: Wang, Qizhang ; Geara, Jennifer ; Niu, Guanglin ; Toma, Maria A ; Bian, Xiaowei ; Zhang, Letian ; Li, Dongqing ; Sommar, Pehr ; Xu Landén, Ning ; Liu, Zhuang ; Piipponen, Minna ; Wang, Aoxue

AbstractBackgroundSkin wound healing involves a complex gene expression programme that remains largely undiscovered in humans. Circular RNAs (circRNAs) and microRNAs (miRNAs) are key players in this process.ObjectivesTo understand the functions and potential interactions of circRNAs and miRNAs in human skin wound healing.MethodsCircRNA, linear RNA and miRNA expression in human acute and chronic wounds were analysed with RNA sequencing and quantitative reverse transcription polymerase chain reaction. The roles of circASH1L(4,5) and miR-129-5p were studied in human primary keratinocytes (proliferation and migration assays, microarray analysis) and ex vivo wound models (histological analysis). The interaction between circASH1L(4,5) and miR-129-5p was examined using luciferase reporter and RNA pulldown assays.ResultsWe identified circASH1L(4,5) and its interaction with miR-129-5p, both of which increased during human skin wound healing. Unlike typical miRNA sponging, circASH1L enhanced miR-129 stability and silencing activity by protecting it from target-directed degradation triggered by NR6A1 mRNA. Transforming growth factor-β signalling – crucial in wound healing – promoted circASH1L expression while suppressing NR6A1, thereby increasing the abundance of miR-129 at the post-transcriptional level. CircASH1L and miR-129 enhanced keratinocyte migration and proliferation, crucial processes for the re-epithelialization of human wounds.ConclusionsOur study uncovered a novel role for circRNAs as protectors of miRNAs and highlights the importance of regulated miRNA degradation in skin wound healing.

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MIR129

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