Osivax, a biopharmaceutical firm, has initiated a Phase 1 clinical trial for its sarbecovirus vaccine candidate, OVX033, in France.

This study explores the effectiveness of RP-1664, a selective oral inhibitor of polo-like kinase 4 (PLK4), targeting adult and adolescent patients with TRIM37-high solid tumors.

Theratechnologies Inc. has achieved a significant milestone in its Phase 1 clinical trial for sudocetaxel zendusortide.

Neurophth Therapeutics has successfully enrolled the final participant in its Phase I/II clinical study of Opvika® (Esonadogene Imvoparvovec), a treatment for Leber hereditary optic neuropathy (LHON) caused by the ND4 gene mutation.

Tharimmune, Inc. has successfully completed a Phase 1 clinical trial for TH104, a transmucosal buccal film containing nalmefene, which is well-tolerated with mild side effects.

Biopharmaceutical firm Iterion Therapeutics has initiated a Phase 1b/2a clinical trial for its lead drug candidate, tegavivint, which is designed to inhibit Transducin beta-like protein 1 (TBL1).

Immune-Onc Therapeutics has entered into a clinical trial collaboration with Roche to assess the potential of IO-108 as a first-line treatment for hepatocellular carcinoma (HCC).

NextPoint Therapeutics has initiated a Phase 1 clinical trial for NPX887, a drug designed to target solid tumors with high expression of the HHLA2/B7-H7 antigen.

Monopar Therapeutics Inc. has been given the green light by the Human Research Ethics Committee (HREC) in Australia to initiate a Phase 1 dosimetry study for its innovative radiopharmaceutical, MNPR-101-Zr.

Arvinas Inc. has initiated its Phase 1 clinical trial of ARV-102, a novel oral PROTAC® protein degrader aimed at treating neurodegenerative diseases.

Aleta Biotherapeutics, a company specializing in immuno-oncology, has initiated a Phase 1/2 clinical trial for its innovative biologic, ALETA-001.

ReCode Therapeutics, a company specializing in genetic medicine, has initiated a Phase 1 clinical trial for RCT2100, an innovative inhaled treatment for cystic fibrosis (CF).