MWN105 NCT07804810 Clinical Landscape 2026

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This Clinical Landscape Report was built with PatSnap Life Sciences MCP workflows. Clinical Trials MCP supplies protocol and result records, Drug & Asset MCP adds asset context, and Company & Deal Intelligence MCP resolves sponsor background. Use the same structured MCP building blocks in your research workflow.

Data snapshot: 16 September 2026. This strategic research report is not medical, regulatory or investment advice. Trial status and dates can change.

Phase 2

Clinical phase

Completed

Recruitment status

120

Planned enrollment

2026-03-21

Primary-completion proxy

Executive view

NCT07804810 evaluates MWN105 in Prediabetic State. The disclosed sponsor is Shanghai Minwei Biotechnology Co., Ltd, the design is Interventional, and the geographic footprint is China. The first listed primary endpoint is Percentage Change from Baseline in Body Weight at Week 24., assessed over Baseline, Week 24.

The key landscape question is whether this protocol can generate a clinically interpretable signal relative to nearby programs. Phase alone is not a measure of evidence quality. Endpoint relevance, comparator choice, masking, enrollment feasibility, patient selection, country coverage and follow-up must be considered together.

PatSnap MCP Servers make this assessment reproducible by keeping protocol facts, result evidence, asset attributes and sponsor identity in separate structured calls.

How the MCP evidence stack was assembled

Clinical Trials MCP clinical_trial_fetch retrieved the design, outcomes, phase, status, enrollment, sponsor, countries and timing for NCT07804810 and selected peers. clinical_trial_result_fetch supplied detailed result records from the wider Prediabetic State landscape. Drug & Asset MCP drug_fetch was queried for MWN105, while Company & Deal Intelligence MCP organization_fetch was queried for Shanghai Minwei Biotechnology Co., Ltd.

This separation reduces a common diligence error: treating a registry label, a company description or a result excerpt as if each represented the complete evidence package. Explore the source workflow at the PatSnap MCP marketplace.

Trial landscape table

Trial	Asset / intervention	Phase / status	Sponsor	Geography	Primary endpoint	Readout proxy
NCT07804810	MWN105	Phase 2 / Completed	Shanghai Minwei Biotechnology Co., Ltd	China	Percentage Change from Baseline in Body Weight at Week 24. Baseline, Week 24	2026-03-21
NCT07803705	Mazdutide	Not Applicable / Not yet recruiting	Shanghai Tongji Hospital	China	Percentage change in Intrapancreatic Fat Deposition (IPFD) from baseline From baseline to Week 48	2028-06-30
NCT07803744	Acetaminophen	Phase 1 / Not yet recruiting	Eli Lilly & Co.	United States	Pharmacokinetics (PK): Time of Maximum Observed Drug Concentration (Tmax) of Acetaminophen Predose on Day 1 through 36 hours post dose	2026-12-01
NCT07804797	MWN-109	Phase 2 / Active, not recruiting	Shanghai Minwei Biotechnology Co., Ltd	China	Percentage change in body weight compared to baseline after 24 weeks of drug administration Baseline, Week 24	2026-09-01
NCT07805291	MT-1	Not Applicable / Completed	University of Aberdeen	United Kingdom	The participant's appetite response on the test day (day 3rd, 7th, 17th, and 21st) On test days recorded at timepoints 0, 30, 60, 90, 120, 150 and 180 m…	2025-04-14

The table aligns endpoints, sponsors, phases, geographies and readout proxies. It is descriptive, not a head-to-head efficacy comparison. Differences in population, baseline risk, intervention schedule and follow-up can dominate apparent cross-trial differences.

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Protocol design and endpoint interpretation

NCT07804810 is a Phase 2, completed study with 120 planned participants. Allocation is Randomized, masking is Double, and the intervention model is Parallel Assignment.

The primary endpoint is “Percentage Change from Baseline in Body Weight at Week 24.” over “Baseline, Week 24.” No additional primary-endpoint description was returned in the selected field set.

Interpretation should test whether the endpoint captures a clinically meaningful change, whether its time horizon matches the proposed biology, and whether treatment discontinuation or missing data can bias the estimate. The planned enrollment of 120 should be assessed against expected effect size, event frequency, multiplicity, subgroup plans and attrition.

No named control drug was returned in the protocol field set. A placebo comparator can strengthen internal efficacy assessment, while an active comparator may better test clinical differentiation. Single-arm and open-label programs require greater weight on objective outcomes, independent assessment and external benchmarks.

Indexed readouts in the surrounding landscape

3 recent result records were selected as contextual evidence for Prediabetic State. These records do not establish direct evidence for NCT07804810 unless the registration number matches.

Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity

Phase 4; n=79; Change in Stress Myocardial Perfusion Reserve on Cardiac MRI(Least Squares Mean): P-Value = 0.97; Change in Stress Myocardial Perfusion Reserve on Cardiac MRI(Least Squares Mean) = 0.154 ratio of mL/min/g per mL/min/g (95% Confidence Interval, -0.122 to 0.430) Source: https://clinicaltrials.gov/ct2/show/results/NCT04519164

Lifestyle Intervention Plus Metformin to Treat Frailty in Older Veterans With Obesity

Phase 3; n=114; Change in the Modified Physical Performance Test (PPT)(Mean) = 1.2 Score on a Scale (Standard Error, 0.4); Change in the Modified Physical Performance Test (PPT)(Mean): Mean Difference (Net) = 2.5(95% CI, 1.2 - 3.8), P-Value = 0.0002; Mean Difference (Net) = 0.1(95% CI, -1.2 to 1.4), P-Value = 0.92 Source: https://clinicaltrials.gov/ct2/show/results/NCT04221750

A Phase 2, Single-Arm, Open-Label Study to Evaluate the Safety and Efficacy of ARD-101 in Patients With Prader-Willi Syndrome (PWS)

Phase 2; n=19; Incidence of Treatment Emergent Adverse Events (TEAE) = 8 Participants ; Incidence of Treatment Emergent Adverse Events (TEAE) = 5 Participants Source: https://clinicaltrials.gov/ct2/show/results/NCT05153434

Result fields should be reconciled with the source record before quantitative comparison. Population definitions, analysis sets, dose cohorts, estimands, confidence intervals, rescue therapy and follow-up can materially change the meaning of a numerical endpoint. Clinical Trials MCP supports repeatable refreshes as result records change.

Asset and sponsor context

MWN105 is indexed as Fc fusion protein with FGF21R x GIPR x GLP-1R biology and a global stage of Phase 2. The asset profile lists Shanghai Minwei Biotechnology Co., Ltd as an originator or developer.

No exact Company & Deal Intelligence profile was returned for Shanghai Minwei Biotechnology Co., Ltd. Sponsor identity is retained from the trial protocol without adding unsupported corporate claims.

For execution diligence, monitor sponsor ownership, collaborator additions, site expansion, protocol amendments and enrollment revisions. A change in ownership or geography can alter operational confidence as well as the commercial meaning of a future readout.

Development white space

Endpoint white space. Determine whether a more patient-relevant outcome, longer durability window or blinded central assessment would resolve uncertainty left by the current endpoint.
Population white space. Test biomarker-defined, treatment-line or risk-stratified subgroups where effect size and unmet need could be clearer.
Comparator white space. Identify whether the study can support differentiation against the current standard of care rather than only activity against baseline or placebo.
Geographic white space. Assess whether the disclosed footprint supports recruitment, regulatory transferability and commercial generalizability.
Sequencing white space. Clarify whether MWN105 is intended for monotherapy, combination, maintenance, rescue or an earlier treatment line.

White space should be framed as an unanswered development question, not merely an unoccupied mechanism label. A credible program closes a measurable clinical uncertainty with a design that can be executed and interpreted.

Strategic implications and next readouts

For sponsors, the endpoint hierarchy, safety window, enrollment pace and protocol amendment history should all support the same target product profile. Advancement criteria should be set before the readout and tied to clinical effect, uncertainty, tolerability and operational feasibility.

For business-development teams, differentiation may come from a sharper population, stronger comparator, more durable benefit, simpler delivery or clearer sequencing role. For investors, the central risk is evidence quality relative to time and capital, not the phase label in isolation.

Track recruitment status, enrollment changes, primary-completion timing, endpoint revisions, new result records, sponsor ownership and collaborator changes. Re-run the PatSnap MCP workflow when a surrogate becomes a clinical outcome, a single-country study expands, the comparator changes or a new result materially shifts the competitive benchmark.

Source trail and bottom line

Anchor trial: NCT07804810
Protocol source: https://clinicaltrials.gov/study/NCT07804810
MCP sources: Clinical Trials MCP (clinical_trial_fetch and clinical_trial_result_fetch); Drug & Asset MCP (drug_fetch); Company & Deal Intelligence MCP (organization_fetch).
Data snapshot: 16 September 2026.

MWN105 in Prediabetic State is best understood through the interaction of protocol design, surrounding readouts, asset context and sponsor execution. The current record makes Percentage Change from Baseline in Body Weight at Week 24. and 2026-03-21 the leading decision points.

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