Latest Hotspot

Cytonics Finishes Phase 1 Enrollment for CYT-108 Study in Knee Osteoarthritis

10 September 2024
3 min read

Cytonics Corporation, a private biotechnology firm focused on creating biologic treatments for inflammatory musculoskeletal disorders, has revealed that they have completed participant enrollment for their Phase 1 clinical trial of CYT-108. CYT-108 is a recombinant form of the blood serum protease inhibitor alpha-2-macroglobulin, and it is being investigated as a potential disease-modifying therapy for osteoarthritis (OA).

👇Discover comprehensive information about this drug, from its R&D status, core patents, clinical trials to approval status in global countries, by simply clicking on the image below. Dive deep into our drug database now.

图形用户界面, 应用程序, 电子邮件

描述已自动生成

This pioneering clinical trial involving human subjects is a multi-site, 6-month, double-blind randomized controlled trial (RCT) including 22 participants, allocated equally between the treatment and placebo groups. It is designed to assess the safety and effectiveness of CYT-108 in individuals with unilateral, mild-to-moderate primary osteoarthritis (OA) of the knee. The main safety measures will examine CYT-108’s tolerability when administered through an intra-articular injection directly into the affected knees. Secondary endpoints will look at improvements in patients' self-reported pain and joint mobility, while an exploratory endpoint will measure peptide fragments in blood serum as an indicator of cartilage degradation. Thus far, there have been no adverse events related to the drug, and CYT-108 has been well-tolerated by all participants.

"We are ecstatic to have finished enrolling all 22 subjects across our three clinical locations in Australia, exceeding our recruitment timeline by more than a month. This will accelerate our Phase 1 clinical study report and our Investigational New Drug (IND) application submission to the FDA in 2025, moving us closer to providing the first and only disease-modifying treatment for osteoarthritis. We are extremely impressed by the recruitment capabilities of our clinical sites and eagerly anticipate continuing our collaboration with these researchers and clinicians as we progress into Phase 2," said Joey Bose, President & CEO of Cytonics Corp.

👇Explore the latest research progress on drug-related developments, indications, therapeutic organizations, clinical trials, results, and patents by clicking on the targeted picture link below. Unfold a world of comprehensive information on this target in just a click!

图形用户界面, 应用程序

描述已自动生成

According to the data provided by the Synapse Database, As of September 9, 2024, there are 22 investigational drugs for the Peptide hydrolase targets, including 30 indications, 21 R&D institutions involved, with related clinical trials reaching 12, and as many as 302 patents.

The drug CYT-108 is a recombinant protein that targets peptide hydrolase and is intended for use in treating skin and musculoskeletal diseases. Its active indications include primary osteoarthritis of the knee NOS and osteoarthritis. The drug is being developed by Cytonics Corp., and its highest phase of development globally is Phase 1. As a recombinant protein, CYT-108 is a therapeutic agent that has been engineered from genetic material to target specific biological processes. In this case, the drug targets peptide hydrolase, an enzyme involved in the breakdown of peptide bonds in proteins. By targeting this enzyme, it is expected that CYT-108 may have a beneficial effect on skin and musculoskeletal diseases, particularly in the treatment of primary osteoarthritis of the knee NOS and osteoarthritis.

图形用户界面, 文本, 应用程序

描述已自动生成

Pharma Frontiers: Daily Digest of Global Pharmaceutical News – Sep 10
Pharma Frontiers: Daily Digest of Global Pharmaceutical News – Sep 10
10 September 2024
Sep 10th latest updates in the global new drug development field, including progress in new drug research and development, transaction information, and partnership developments.
Read →
Huonslab Reports Positive In Vivo PK Results for Trastuzumab/HyDIFFUZETM vs. Standard Trastuzumab and rHuPH20 Co-formulation
Latest Hotspot
2 min read
Huonslab Reports Positive In Vivo PK Results for Trastuzumab/HyDIFFUZETM vs. Standard Trastuzumab and rHuPH20 Co-formulation
10 September 2024
Huonslab Reveals Favorable In Vivo PK Study Outcomes for Trastuzumab/HyDIFFUZETM vs. Commercial rHuPH20 and Trastuzumab Co-formulation.
Read →
NextPoint Therapeutics Unveils NPX372, a New T Cell Engager Targeting B7-H7 in Solid Tumors
Latest Hotspot
3 min read
NextPoint Therapeutics Unveils NPX372, a New T Cell Engager Targeting B7-H7 in Solid Tumors
10 September 2024
NextPoint Therapeutics Reveals NPX372, a Novel Drug Targeting B7-H7 in Solid Tumors, as New T Cell Engager.
Read →
Medigene's MDG1015, a Third-Generation T Cell Therapy, Wins FDA Approval for IND Trials in Solid Tumors
Latest Hotspot
4 min read
Medigene's MDG1015, a Third-Generation T Cell Therapy, Wins FDA Approval for IND Trials in Solid Tumors
10 September 2024
Medigene Gets U.S. FDA Approval for IND of MDG1015, a Novel Third Gen T Cell Therapy Targeting Various Solid Tumors.
Read →
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.