Ponesimod, marketed under the brand names Ponvory and Ponvory Starter Pack, is an oral medication used to treat relapsing forms of multiple sclerosis (MS) in adults. Ponvory (ponesimod) was approved by the U.S. Food and Drug Administration (FDA) on March 18, 2021. This approval provided a new treatment option for individuals with relapsing forms of multiple sclerosis, offering a novel mechanism of action aimed at improving patient outcomes.
Ponesimod belongs to a class of drugs known as selective immunosuppressants. It works by selectively modulating the activity of the immune system to reduce the frequency of MS relapses and slow the progression of physical disability. Ponesimod achieves this by binding to the sphingosine-1-phosphate receptor 1 (S1P1), which is involved in lymphocyte migration. By reducing the number of lymphocytes in the peripheral blood, ponesimod helps to limit the autoimmune attack on the central nervous system seen in MS.
Ponesimod is administered orally in tablet form, with a specific dosing regimen designed to gradually increase the dose over the first 14 days of treatment:
Patients starting ponesimod should use the Ponvory Starter Pack, which contains tablets of different strengths for the titration period. The first dose should be administered under medical supervision, particularly for those with pre-existing cardiac conditions.
Common Side Effects:
Serious Side Effects:
Precautions:
It offers a new option for patients to manage their MS, particularly those who have experienced multiple relapses. As with any medication, it is essential to follow the prescribed regimen and be aware of potential side effects and necessary precautions to ensure safe and effective use.
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