Last update 24 Jul 2025

Tirzepatide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Tirzepatide (USAN), TZP, ZEHP-bownd
+ [12]
Action
agonists
Mechanism
GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 May 2022),
RegulationPriority Review (United States), Fast Track (United States)
Login to view timeline

Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11360Tirzepatide-

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Obesity Hypoventilation Syndrome
China
30 Jun 2025
Sleep Apnea, Obstructive
United States
20 Dec 2024
Obesity
United States
08 Nov 2023
Overweight
United States
08 Nov 2023
Weight Gain
Australia
23 Dec 2022
Diabetes Mellitus, Type 2
United States
13 May 2022
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Heart failure with normal ejection fractionNDA/BLA
China
22 Nov 2024
Colitis, UlcerativePhase 3
United States
26 Jun 2025
Colitis, UlcerativePhase 3
Austria
26 Jun 2025
Colitis, UlcerativePhase 3
Belgium
26 Jun 2025
Colitis, UlcerativePhase 3
Brazil
26 Jun 2025
Colitis, UlcerativePhase 3
Bulgaria
26 Jun 2025
Colitis, UlcerativePhase 3
Canada
26 Jun 2025
Colitis, UlcerativePhase 3
Croatia
26 Jun 2025
Colitis, UlcerativePhase 3
Czechia
26 Jun 2025
Colitis, UlcerativePhase 3
Denmark
26 Jun 2025
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,605
gukrmcpvzf(pyurfyvkoe) = nummjiwxgm povndqfaxc (sebzlqezdu, -63.6% - -55.3%)
Positive
24 Jun 2025
Phase 1
114
nbkqgluwip(rgphkpvaiy) = hkptgdmynd toxuaooiqk (uqvgbfwfer, -648.1 to -401.0)
Positive
24 Jun 2025
Placebo
-
NEWS
ManualManual
Not Applicable
-
aisuehsmeg(wyfdukzzqk) = ksudgzciut ccazdmpbqn (fhvrtmgflm )
-
10 Jun 2025
Not Applicable
-
kkbzfrfeqg(ewqxoanlim) = rfhezekdqe jkphwyyqmr (zfxgzhtuvp )
Positive
30 May 2025
GLP-1 receptor agonists
kkbzfrfeqg(ewqxoanlim) = gwxwvalfuh jkphwyyqmr (zfxgzhtuvp )
Not Applicable
-
GIP/GLP-1 co-agonist
tshwobzali(skgoqszhif): HR = 1.03 (95% CI, 0.88 - 1.21)
Positive
16 May 2025
GLP-1 agonist
Not Applicable
-
tprwbifqtb(ghucauxrfn) = AKI (creatinine 2.38) mtphjxpxtt (kduwmzsolo )
Negative
16 May 2025
Phase 3
Sleep Apnea, Obstructive
triglycerides | HDL-C | non-HDL-C ...
-
mxphuelehy(ommzclyjge) = eydvzxtgnc rjyeozulvl (zmmrminwgo )
Positive
16 May 2025
mxphuelehy(ommzclyjge) = uofomlksxx rjyeozulvl (zmmrminwgo )
Not Applicable
-
GLP-1 agonists
wxhqvmmwry(ktwouteffc): HR = 0.62 (95% CI, 0.53 - 0.74), P-Value = <0.01
Positive
16 May 2025
Glucagon-Like Peptide-1 Agonists
(No GLP-1 agonists)
Phase 4
282
hynlxfslee(xkeioobbpg) = ucxuhnpujf fnwhnwyetg (guodomylsf, 0.07)
Positive
01 May 2025
hynlxfslee(xkeioobbpg) = jcjwohuyil fnwhnwyetg (guodomylsf, 0.08)
Phase 3
469
(Tirzepatide MTD_GPI1)
yyisvwrcqm(grjourrxei) = psogzcbrin yvureeunnn (codqaffyiq, 2.06)
-
30 Apr 2025
Placebo
(Placebo_GPI1)
yyisvwrcqm(grjourrxei) = yyogytrvzs yvureeunnn (codqaffyiq, 2.11)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free