Biliary pain

Ananta's Ayurvedic Herbal Complex Is Backed By a Millennium of Application in Traditional Indian Medicine FORT LAUDERDALE, Fla., Sept. 7, 2023 /PRNewswire/ -- The liver is a critical part of a healthy, functioning body. John Hopkins Medicine explains that the liver performs over 500 functions, including key activities such as bile production and blood filtration. A healthy liver is an essential part of a long, well-lived life. This fits well with health brand Ananta's slogan to provide "endless care about your health." "Our goal is to provide our customers with the herbal and medicinal tools they need to preserve and protect their health," says Ananta president Pradeep Jain. "The liver is a major part of ongoing healthy bodily function, which is why we created Hepaklin." Hepaklin is a dietary supplement formulated to maintain healthy liver function and support a strong biliary system. It consists of seven herbal ingredients that are renowned in ancient Ayurvedic medicine for their natural ability to help improve the metabolic processes of the body — including bile production, gallbladder function, and other liver-related health benefits. Hepaklin also shields the body from the effects of abusive behavior. It is a natural source of health that can protect liver cells from the damaging effects of alcohol, drugs, and other toxic substances. A full course of the supplement requires two packs and takes roughly three months to complete. The foundational wisdom behind Hepaklin is important, but the product's true value comes from combining that wisdom with modern nutraceutical capabilities. That's where Ananta comes into the picture. Hepaklin may be backed by ancient tradition, but it is also an herbal remedy formulated on science. The brand has repurposed the traditional wisdom of Indian Ayurvedics to create a precise product that speaks to the needs of modern informed consumers. Ananta is known for its knowledgeable and experienced staff and its ability to create effective in-house formulations. In the case of Hepaklin, the group applied modern research methods to create the ideal combination of ingredients for a natural liver supplement and then tested those compounds through clinical trials. In one study, Hepaklin was tested to observe its effects on lipid and carbohydrate metabolism as well as liver function and gallbladder contractility. The study was conducted with patients with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). The results after 12 weeks revealed significant decreases in biliary pain and biliary sludge. It was also reported that Hepaklin has "a normalizing effect on the contractility of the gallbladder and reduces the severity of biliary pain in patients with metabolic syndrome and non-alcoholic fatty liver disease." Finally, the herbal product was well-tolerated by participants and shown to be safe with minimal observed side effects. From this lack of significant side effects to the use of proven herbal ingredients, Hepaklin offers consumers a powerful way to support the body's biliary functions and maintain a healthy liver. As is the case with all of Ananta's products, it is a unique health tool that makes it easier to live a long and fulfilling life. About Ananta Medicare Ananta Medicare Limited was founded in 1999 and consists of a group of companies that specialize in the manufacturing and marketing of high-quality products with natural components. These include generic medicines, dietary supplements, and cosmetics. The brand has plants in India, each dedicated to specific manufacturing needs. It also has offices in the UK, India, and Ukraine. The company's vision has always been to protect and preserve health and increase quality of life. Learn more at . Media Contact: Pradeep Jain Director 17867679500 [email protected] SOURCE Ananta

The liver produces bile, which the intestine uses for digestion. For the transport of bile, the liver relies on a network of microscopic tubings, known as bile canaliculi, formed by liver cells called hepatocytes. When the outflow of bile to the intestine is blocked, it collects in the liver and can lead to serious liver disease. Researchers found that high pressure in the bile canaliculi alters the structure of the liver tissue. They found that elevated pressure leads to the obviation of apical bulkheads, structures known to reinforce the canaliculi. Subsequently, bile canaliculi enlarge into liver cell rosettes that are observed in many liver diseases. This study identifies pressure to be a potential common cause of various liver diseases with biliary obstruction and thus contributes to a better understanding of liver diseases. The liver produces bile, which the intestine uses for digestion. For the transport of bile, the liver relies on a network of microscopic tubings, known as bile canaliculi, formed by liver cells called hepatocytes. When the outflow of bile to the intestine is blocked, it collects in the liver and can lead to serious liver disease. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden together with experts from the Carl Gustav Carus University Hospital (UKD) Dresden and Oslo University Hospital in Norway found that high pressure in the bile canaliculi alters the structure of the liver tissue. They found that elevated pressure leads to the obviation of apical bulkheads, structures known to reinforce the canaliculi. Subsequently, bile canaliculi enlarge into liver cell rosettes that are observed in many liver diseases. This study identifies pressure to be a potential common cause of various liver diseases with biliary obstruction and thus contributes to a better understanding of liver diseases. The research groups led by Marino Zerial, director at the MPI-CBG, and Jochen Hampe at the UKD, in collaboration with colleagues at the Oslo University Hospital, have found initial evidence that bile stasis leads to excess pressure in the microscopic bile canaliculi. Long-term overpressure could damage liver tissue and, consequently, lead to liver diseases such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC). Zooming into the bile cancaliculi using high-resolution microscopy, scientists now understand better what happens in the microcirculatory system of the liver tissue when it's under high pressure. Hepatocytes form transversal connections called "apical bulkheads," stabilizing the bile canaliculi tubules. But when there's too much pressure from bile, the stabilizing supporting hepatocytes start to break down. This leads to the widening of the tubes and the formation of new structures called "rosettes." For decades, physicians have used liver rosettes as a marker in the diagnosis of cholestatic liver disease to detect these disorders. In these structures, abnormal liver cells arrange like rose petals around a small opening. Such rose-like structure can be identified in tissue samples. Why these structures form, however, was unclear up to today. Thanks to state-of-the-art fluorescence microscopy techniques, the researchers understood that liver cell rosettes are cross-sections of the bile canaliculi suffering excess pressure due to bile stasis. The scientists have thus solved a mystery about the causes of the formation of these structures, which are considered a distinguishing feature of biliary congestion in liver tissue. This suggests a direct link between increased pressure in the bile canaliculi and cholestatic liver disease and improves our understanding of these diseases. Carlotta Mayer, the first author of the study, explains, "We see liver cell rosettes already in the early stages of PSC in the tissue. Thus, they are potential diagnostic markers of early stages of PSC and other liver diseases." The research findings suggest that excess pressure in the bile canaliculi may also play a role in other liver diseases, such as hepatitis. This could open new avenues for research into liver diseases. "This work is an excellent example of the need for interdisciplinary research bridging medicine and cell biology. We now need to focus on the molecular mechanism of liver rosette formation to open new perspectives for treatment of these diseases," emphasizes the head of the research group, Prof. Marino Zerial.