Synonyms Histiocytic and Dendritic Cell Neoplasm, Histiocytic and Dendritic Cell Neoplasms, Histiocytic and Dendritic Cell Tumors + [1] |
Introduction A group of rare tumors that affect the hematopoietic and lymphoid tissues. The cells of origin are the histiocytes and accessory cells. This category includes the following: Langerhans cell histiocytosis, Langerhans cell sarcoma, indeterminate dendritic cell histiocytosis, interdigitating dendritic cell sarcoma, histiocytic sarcoma, disseminated juvenile xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman-Destombes disease, ALK-positive histiocytosis, and follicular dendritic cell sarcoma. |
Target |
Mechanism XPO1 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date03 Jul 2019 |
Target |
Mechanism PD-1 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date04 Sep 2014 |
Target |
Mechanism DNA inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date16 Nov 1959 |
Start Date05 Jan 2024 |
Sponsor / Collaborator ![]() [+1] |
Start Date08 Feb 2021 |
Sponsor / Collaborator ![]() [+1] |
Start Date07 Dec 2017 |
Sponsor / Collaborator |