Last update 27 Apr 2026

Selinexor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CRM1-nuclear-export-inhibitor, NEXPOVIO, Selinexor
+ [13]
Action
inhibitors
Mechanism
ACADS inhibitors(acyl-CoA dehydrogenase short chain inhibitors), XPO1 inhibitors(Exportin-1 protein inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (03 Jul 2019),
RegulationPriority Review (United States), Accelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Conditional marketing approval (China), Orphan Drug (South Korea), Orphan Drug (Australia), Priority Review (South Korea), Fast Track (United States)
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Structure/Sequence

Molecular FormulaC17H11F6N7O
InChIKeyDEVSOMFAQLZNKR-RJRFIUFISA-N
CAS Registry1393477-72-9

External Link

KEGGWikiATCDrug Bank
D11222Selinexor

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Follicular Lymphoma
Indonesia
05 Mar 2025
Refractory Multiple Myeloma
China
14 Dec 2021
Relapse multiple myeloma
China
14 Dec 2021
Diffuse large B-cell lymphoma recurrent
Israel
04 Feb 2021
Diffuse large B-cell lymphoma refractory
Israel
04 Feb 2021
Diffuse Large B-Cell Lymphoma
United States
22 Jun 2020
Multiple Myeloma
United States
03 Jul 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory acute myeloid leukemiaPhase 3
China
29 Jan 2023
Relapsing acute myeloid leukemiaPhase 3
China
29 Jan 2023
Endometrial CarcinomaPhase 3
China
27 Oct 2021
Endometrial CarcinomaPhase 3
China
27 Oct 2021
Post-polycythemia vera myelofibrosisPhase 3
United States
11 Mar 2021
Post-polycythemia vera myelofibrosisPhase 3
Australia
11 Mar 2021
Post-polycythemia vera myelofibrosisPhase 3
Belgium
11 Mar 2021
Post-polycythemia vera myelofibrosisPhase 3
Bulgaria
11 Mar 2021
Post-polycythemia vera myelofibrosisPhase 3
Canada
11 Mar 2021
Post-polycythemia vera myelofibrosisPhase 3
Czechia
11 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
18
ywrzcuvhiw = dgomuyniee mwuuijymjv (yuzmkqbleq, euetewnwmt - umennudpob)
-
06 Mar 2026
Phase 1/2
4
rjiptuargp = feqanumrtu pvijdosuju (jequhcyptu, vmrxanywio - btxhmvpqgk)
-
29 Jan 2026
Phase 1
17
Gemcitabine + Selinexor
rhtvkyvnea(cpbbcvgdan) = gemcitabine at 1200 mg/m2 at 10 mg/m2/min followed by 60 mg weekly selinexor jouvqfrdtv (kifrfywgzw )
Positive
20 Jan 2026
Phase 2
44
Selinexor + R-CHOP
zbyrcehbyt(inrxzdxzzn) = ezmhllywwz ktusqecrjf (zydapaqpwk )
Positive
06 Dec 2025
Phase 1/2
21
taycocahiu(kedrcnquqj) = rwcqibnikn ojcnyjhhib (sygpakhedn )
Positive
06 Dec 2025
Phase 2
47
fudurxtlqd(mlvitbaryd) = wkfnaorabj tpozrnimpg (gooxvcxyfs )
Positive
06 Dec 2025
Phase 1/2
39
cuvqyvtocx(cazvoshrwd) = utgcmrkyee hasqlxdhmq (lrunyxrnkl )
Positive
06 Dec 2025
Phase 2
11
Selinexor plus R-CHOP
vuflenfnsm(vhomwshdia) = ubbdimftiv erkfybfeew (uvaggatcfa )
Positive
06 Dec 2025
Phase 1
20
agkfmtwunc(qyfgbeyjhe) = fmkftqeqiq bfnresvbnv (juccaqzduu )
Positive
06 Dec 2025
agkfmtwunc(qyfgbeyjhe) = vstboeiiwg bfnresvbnv (juccaqzduu )
Phase 3
Multiple Myeloma
Maintenance
149
seepwdtkjh(qkaonmxjyh) = vrnonhtjnv qivegrissm (bzvfxmnifo )
Negative
06 Dec 2025
seepwdtkjh(qkaonmxjyh) = ltnjpvlskc qivegrissm (bzvfxmnifo )
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Regulation

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