BK virus infection

PRESS RELEASE Memo Therapeutics AG Strengthens Management Team Appoints Kristie B. Clemmer as VP Clinical Operations and Dr. Maartje Verschuur as VP CMC and Supply Chain Management Schlieren / Zurich, Switzerland, February 5, 2024 – Memo Therapeutics AG (or “MTx”), a late-stage biotech company developing best-in-class therapeutic antibodies for viral infections and oncology, announced today that it has strengthened its senior team with the appointments of Kristie B. Clemmer and Dr. Maartje Verschuur as VP Clinical Operations and VP CMC and Supply Chain Management, respectively, effective today. Ms. Clemmer is an accomplished global clinical research leader with over 20 years of experience directing international clinical operations. She most recently served as VP, Clinical Operations at AM-Pharma where she led teams across North America, Europe, and Japan for a Phase III critical care trial in sepsis-associated acute kidney injury. Ms. Clemmer previously held senior leadership positions at the Contract Research Organizations PRA Health Sciences and PPD. Prior to her career in clinical research, Ms. Clemmer was an intensive care unit/emergency room nurse. She holds a BSc degree in Nursing with a Minor in Biology from Barton College, US. Dr. Verschuur has more than 19 years of experience in biologics drug development and manufacturing, with a focus on Chemistry Manufacturing and Controls (CMC). She has broad knowledge in the late-stage development and commercialization of biologics, and was a key contributor to five product candidates that have successfully gained market approvals. She joins MTx from AM-Pharma, where she was responsible for all drug substance activities including Phase III clinical manufacturing. Dr. Verschuur previously held a variety of senior CMC roles including at Venn Life Sciences BV, Batavia Biosciences BV and AbbVie Inc. Dr. Verschuur completed her PhD in Molecular/Cell Biology from Leiden University, The Netherlands and has an MSc in Biotechnology from Wageningen University, The Netherlands. Eric van den Berg, CEO of MTx, commented: “It is a pleasure to welcome Kristie and Maartje to MTx. They bring a wealth of experience successfully directing global clinical operations and biologics drug development and manufacturing. Their insights and expertise will be instrumental as we progress our Phase II trial and prepare for Phase III of our lead program, AntiBKV, and develop our promising pipeline of best-in-class therapeutic antibodies.” -Ends- About Memo Therapeutics AGMemo Therapeutics AG (“MTx”) is a late-stage biotech company developing best-in-class therapeutic antibodies to transform the lives of patients with viral infections and cancer. MTx’s lead program, AntiBKV, is a highly effective and safe neutralizing antibody to treat BK virus infection in kidney transplant recipients. This infection can lead to nephropathy, loss of kidney function, as well as organ failure and rejection. MTx’s pipeline consists of additional candidate therapeutic antibodies focusing on infectious diseases, such as cytomegalovirus (“CMV”), immuno-oncology targets as well as a partnership with Ono Pharmaceutical. MTx is a private company located in Schlieren / Zurich, Switzerland. Contacts Memo Therapeutics AG info@memo-therapeutics.com ICR ConsiliumAmber Fennell, Ashley Tappmemotx@consilium-comms.com+44 (0)20 3709 5700

Cell-therapy developer Allovir announced Thursday that its board of directors approved a workforce reduction of approximately 95% to curtail costs and preserve capital. The decision comes hot on the heels of the discontinuation of late-stage studies of posoleucel.The downsizing process, which will commence in the first quarter of 2024, is likely to be completed by April 15. AlloVir, which previously indicated it had just over $200 million in cash, foresees incurring around $13 million in personnel-related restructuring expenditures, covering severance and other benefits.Narrowed pipelineIn December, following recommendations from independent data safety monitoring boards, AlloVir discontinued three Phase III trials of posoleucel, an off-the-shelf multi-virus-specific T-cell therapy, due to futility. However, no safety concerns were noted in the trials, which were investigating posoleucel for the prevention of clinically significant infections or diseases by multiple viruses, treatment of virus-associated hemorrhagic cystitis and treatment of adenovirus following allogeneic haematopoietic cell transplant.At the time, the company announced plans to analyse the data for potential subpopulation benefits, while evaluate its pipeline and exploring strategic options. AlloVir is also studying posoleucel for the treatment of BK virus infection in adult kidney transplant patients, with its earlier-stage assets including the off-the-shelf candidates ALVR106 and ALVR107.

Mr. van den Berg is an industry veteran with proven track record in building high-performance teams and delivering on strategic and financial transactions ZURICH--(BUSINESS WIRE)-- Memo Therapeutics AG (“MTx”), a late-stage biotech company developing best-in-class therapeutic antibodies, announced today the appointment of Erik van den Berg as Chief Executive Officer (CEO). This press release features multimedia. View the full release here: Erik van den Berg, CEO of Memo Therapeutics AG (Photo: Business Wire) Mr. van den Berg joins MTx with over 25 years’ industry experience and proven track record in leading and growing companies. During his career, Mr. van den Berg has successfully completed over 20 transactions and partnerships, including a $600 million alliance with Pfizer, $290 million partnership with Kyowa Kirin and $500M in equity and debt financings for biotechnology companies from seed through IPO. He succeeds Dr. Karsten Fischer, who stepped down to pursue other opportunities. “As Memo continues to make progress to address unmet medical needs of patients, Erik is the perfect person to lead the company through late-stage clinical development and towards potential commercialization of our lead program, AntiBKV. On behalf of the Board and entire team, I’d like to welcome Erik to MTx and look forward to our future endeavors,” said Elias Papatheodorou, Chairman of MTx’s Board of Directors. “I’d also like to thank Dr. Karsten Fischer who served as our CEO for the past 5 years for his dedication and leadership in taking our technological approach into the clinic with multiple antibody candidates.” Mr. van den Berg was CEO of AM-Pharma for over 12 years and remains on its Board. He is also Chairman of Step Pharma, TargED Therapeutics, co-founder and previous (executive) Chairman of Lava Therapeutics and co-founder and previous (executive) Chairman of Heatmatrix Group (sold to BosNieuwkerk). Previously, Mr. van den Berg also held business development roles at Organon and IsoTis (sold to Integra Lifesciences). Mr. van den Berg holds a master’s degree in chemistry from the University of Utrecht and an MBA from Manchester Business School. “Memo has already made great strides in its development of novel antibody candidates. As CEO, I look forward to continuing this momentum and build on the great progress made recently with AntiBKV in the clinic and its Fast Track designation from the FDA, as well as the recent successful Series C fundraising,” said Mr. van den Berg. About Memo Therapeutics AG Memo Therapeutics AG (“MTx”) is a late-stage biotech company developing best-in-class therapeutic antibodies to transform the lives of patients with virus infections and cancer. MTx’s lead program, AntiBKV, is a highly effective and safe neutralizing antibody to treat BK virus infection in kidney transplant recipients. This infection can lead to loss of kidney function, as well as organ failure and rejection. MTx’s pipeline consists of additional candidate therapeutic antibodies focusing on infectious diseases, such as cytomegalovirus (“CMV”), immuno-oncology targets as well as a partnership with Ono Pharmaceutical. MTx is a private company located in Schlieren / Zurich, Switzerland. View source version on businesswire.com: Contacts Memo Therapeutics AG info@memo-therapeutics.com Halsin Partners Mike Sinclair +44 (0) 7968 022075 msinclair@halsin.com Source: Memo Therapeutics AG Smart Multimedia Gallery Photo Erik van den Berg, CEO of Memo Therapeutics AG (Photo: Business Wire) Logo View this news release and multimedia online at: