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Last update 08 May 2025

Chronic nephritis

Last update 08 May 2025

Basic Info

Synonyms

Chronic nephritis, NEPHRITIS CHRONIC, Nephritis, chronic

+ [5]

Introduction-

Drugs associated with Chronic nephritis

Abelmoschus manihot extract

Target-

Mechanism-

Active Org.

SZYY Group Pharmaceutical Ltd.

Originator Org.

SZYY Group Pharmaceutical Ltd.

Active Indication

Chronic nephritis

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date07 Jul 2020

Mufangji Decoction

Target-

Mechanism-

Active Org.

Sanwa Shoyaku Co., Ltd.

Originator Org.

Sanwa Shoyaku Co., Ltd.

Active Indication

Cardiac asthma [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date18 Jul 1986

Bawei Dihuang Pill

Target-

Mechanism-

Active Org.

Sanwa Shoyaku Co., Ltd. [+1]

Originator Org.

Sanwa Shoyaku Co., Ltd.

Active Indication

Pollakisuria [+11]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date18 Jul 1986

Clinical Trials associated with Chronic nephritis

CTR20232841

/ CompletedNot Applicable

氢氯噻嗪片在中国健康受试者中进行的单中心、随机、开放、单次（空腹/餐后）口服给药、两制剂、两序列、两周期、交叉的人体生物等效性试验。

[Translation] A single-center, randomized, open-label, single-dose (fasting/postprandial) oral bioequivalence study of hydrochlorothiazide tablets was conducted in healthy Chinese subjects.

主要目的：观察中国健康受试者在空腹/餐后状态下单次口服受试制剂氢氯噻嗪片（规格：25mg；生产企业：云鹏医药集团有限公司）和参比制剂氢氯噻嗪片（商品名：Esidrix®；规格：25mg；持证商：Laboratoires Juvise Pharmaceuticals）后的药代动力学特征，评价空腹/餐后状态下两种制剂的生物等效性。次要目的：观察受试制剂氢氯噻嗪片和参比制剂氢氯噻嗪片（Esidrix®）在中国健康受试者中的安全性。

[Translation]

Primary objective: To observe the pharmacokinetic characteristics of the test preparation hydrochlorothiazide tablets (specification: 25 mg; manufacturer: Yunpeng Pharmaceutical Group Co., Ltd.) and the reference preparation hydrochlorothiazide tablets (trade name: Esidrix®; specification: 25 mg; licensee: Laboratoires Juvise Pharmaceuticals) in Chinese healthy subjects after a single oral administration in the fasting/postprandial state, and to evaluate the bioequivalence of the two preparations in the fasting/postprandial state. Secondary objective: To observe the safety of the test preparation hydrochlorothiazide tablets and the reference preparation hydrochlorothiazide tablets (Esidrix®) in Chinese healthy subjects.

Start Date23 Oct 2023

Sponsor / Collaborator

Yunpeng Pharmaceutical Group Co Ltd.

ITMCTR2024000832

/ RecruitingNot ApplicableIIT

A clinical study on the relationship between the essence of wind evil and proteinuria in chronic nephritis

Start Date06 Jan 2023

Sponsor / Collaborator-

ChiCTR2200063458

/ SuspendedEarly Phase 1IIT

Clinical trial of Modified Shenling Baizhu Powder in the treatment of spleen deficiency and dampness turbidity syndrome of chronic nephritis

Start Date08 Sep 2022

Sponsor / Collaborator

Xiyuan Hospital of China Academy of Chinese Medical Sciences

100 Clinical Results associated with Chronic nephritis

100 Translational Medicine associated with Chronic nephritis

0 Patents (Medical) associated with Chronic nephritis

779

Literatures (Medical) associated with Chronic nephritis

01 May 2025·Phytomedicine

The inhibitory effect of Astragalus flavone extract on hyperuricemia and its underlying molecular mechanism by targeting JNK/AP-1/NLRP3/IL-1β signaling pathway

Article

Author: Qin, Si ; He, Wenjiang ; Zhang, Jieyan ; Lv, Chenghao ; Xia, Hongjuan ; Lin, Xuan

BACKGROUNDHyperuricemia (HUA) is a metabolic disease disturbing human health caused by the overproduction or underexcretion of uric acid (UA). Astragalus is the root of Astragalus membranaceus (Fisch.) Bunge, has notable regulatory effect on chronic nephritis, proteinuria and spontaneous sweating, suggesting it could be a potential anti-HUA agent. However, limited research has been conducted on its anti-HUA effect and mechanism.METHODSThe present study performed untargeted and plasma metabolomics of Astragalus extract to identify the main constituents that can be absorbed and exert effect in mice, and further investigated the underlying mechanism by enzyme activity assay, Western Blotting and molecular docking.RESULTSThe results showed that Astragalus flavone extract inhibited UA synthesis by binding to XOD to hinder substrate binding and inhibiting xanthine oxidase (XOD) protein expression, inhibited JNK/AP-1/NLRP3/IL-1β signaling pathway to alleviate prolonged HUA-induced inflammation and abnormal UA metabolism, and protected the kidney by reducing serum renal function index and improving renal tissue atrophy, fibrosis and tubular dilatation both in vitro and in vivo. Besides, glycitein and isoformononet were identified as the main flavones in Astragalus extract absorbed into the bloodstream of mice, isoformononetin was found to inhibit UA synthesis by direct binding to XOD, and glycitein was found to interact with c-Jun to facilitate UA excretion and inhibit inflammation.CONCLUSIONThis paper represents the pioneering investigation that firstly identifying two flavonoids of Astragalus extract that can be absorbed to fight against HUA, and elucidating their diverse molecular mechanism by targeting JNK/AP-1/NLRP3/IL-1β signaling pathway, UA metabolism and kidney protection.

27 Mar 2025·Spine Surgery and Related Research

Hypertrophic Spinal Pachymeningitis in a Patient with Chronic Antineutrophil Cytoplasmic Antibody-Associated Nephritis: A Case Report

Article

Author: Aburakawa, Kotaro ; Takeda, On ; Kumagai, Gentaro ; Wada, Kanichiro ; Kurose, Akira ; Nitobe, Yohshiro ; Ishibashi, Yasuyuki

04 Feb 2025·Analytical Chemistry

Silver Microdisc Array Electrode Chip for Urea Detection in Saliva Samples from Patients with Chronic Nephritis

Article

Author: Tong, Hongyi ; Yuan, Qiongjing ; Pan, Bingbing ; Xu, Yaojin ; Zhou, Yi-Ge ; Peng, Zhangzhe ; Quan, Jiao ; Wang, Baisheng ; Zou, Sijue ; Meng, Xingyu ; Peng, Meihong

Urea is an important biomarker for diagnosing various kidney and liver disorders. However, many existing methods rely on invasive blood sampling, which can potentially harm patients. Saliva has been recently recognized as a noninvasive and easily collectible alternative to blood for urea quantification. Electrochemical urea detection in saliva remains limited, with catalytic materials typically applied to the electrode surface via drop casting. This results in a random distribution of materials and potential aggregation on the electrode, which inevitably hinders the efficient mass transport of analytes, reducing both detection sensitivity and the utilization of catalytic materials. In this work, a silver nanoparticle (AgNP)-integrated microdisc array electrode chip was fabricated through the in situ growth of AgNPs on polydopamine (PDA) arrays, which were patterned using the microcontact printing (μCP) technique on an indium tin oxide (ITO) glassy substrate. The resulting AgNP microdisc array chip sensor exhibited much higher sensitivity toward urea sensing and greater material utilization as compared to traditional drop-cast electrodes, due to the enhanced mass transfer. Furthermore, the chip sensors demonstrated superior selectivity when challenged with potential interferences. More importantly, reliable urea quantification was achieved in clinical saliva samples from nephritis patients. These results indicate that the current sensor presents great opportunities for developing a noninvasive and sensitive liquid biopsy platform for urea determination in clinical diagnosis applications.

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