Last update 01 Nov 2024

Herpes Zoster Oticus

Last update 01 Nov 2024

Basic Info

Synonyms

Auricular Syndrome of Ramsay Hunt, Facial nerve palsy due to VZV, Facial nerve palsy due to herpes zoster infection

+ [99]

Introduction

A syndrome characterized by facial palsy in association with a herpetic eruption of the external auditory meatus. This may occasionally be associated with tinnitus, vertigo, deafness, severe otalgia, and inflammation of the pinna. The condition is caused by reactivation of a latent HERPESVIRUS 3, HUMAN infection which causes inflammation of the facial and vestibular nerves, and may occasionally involve additional cranial nerves. (From Adams et al., Principles of Neurology, 6th ed, p757)

Drugs associated with Herpes Zoster Oticus

Valnivudine hydrochloride

Target-

Mechanism

Virus replication inhibitors

Active Org.

Bristol Myers Squibb Co. [+1]

Originator Org.

Bristol Myers Squibb Co.

Active Indication

Herpes Zoster Ophthalmicus [+1]

Inactive Indication

Acute herpes zoster neuropathy [+1]

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

phenylketonuria enzyme replacement therapy(Shanghai Yinuoruikang Biomedical Technology)

Target-

Mechanism-

Active Org.

Shanghai Yinuoruikang Biomedical Technology Co., Ltd.

Originator Org.

Shanghai Yinuoruikang Biomedical Technology Co., Ltd.

Active Indication

Herpes Zoster Oticus

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

A101

Target-

Mechanism-

Active Org.

Shanghai Yinuoruikang Biomedical Technology Co., Ltd.

Originator Org.

Shanghai Yinuoruikang Biomedical Technology Co., Ltd.

Active Indication

Herpes Zoster Oticus

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Herpes Zoster Oticus

NCT06542289 / Not yet recruitingNot Applicable

Single-Arm, Multicenter Study to Evaluate the Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve Palsy

Prospective, single-arm, multicenter, single-masked, pivotal study to Evaluate the Safety and Effectiveness of the Blinker system in Participants with Facial Nerve Palsy.

Start Date01 Sep 2024

Sponsor / Collaborator

Neurotrigger

NCT05424302 / RecruitingNot ApplicableIIT

Effect of Peripheral Vestibular Pathology Location on the Ability of Home-based Virtual Reality to Improve Symptoms of Peripheral Vestibular Disorders

This parallel-group randomized controlled trial aims to determine if the location of the lesion(s) in the vestibular system (unilateral versus bilateral, lateral semi-circular canal versus otolith) impacts the effectiveness of adjunct take-home head-mounted display (HMD) virtual reality (VR) therapy in improving patient symptomatology. Fifty patients meeting inclusion criteria will be recruited from the principal investigator's neurotology clinic. Baseline symptomatology questionnaires will be completed, followed by random allocation to virtual reality and control groups. Vestibular rehabilitation and virtual reality protocols will be adhered to for 4 to 8 weeks, followed by symptomatology questionnaires. Data analysis will be conducted to answer the study's objectives.

Start Date01 Jun 2024

Sponsor / Collaborator

University of British Columbia

JPRN-jRCTs061220098 / RecruitingPhase 2IIT

Evaluation of the regeneration facilitating effects of facial nerve decompression using basic fibroblast growth factor for severe facial paralysis

Start Date20 Feb 2023

Sponsor / Collaborator

The Japan Wool Textile Co., Ltd.

100 Clinical Results associated with Herpes Zoster Oticus

100 Translational Medicine associated with Herpes Zoster Oticus

0 Patents (Medical) associated with Herpes Zoster Oticus

1,019

Literatures (Medical) associated with Herpes Zoster Oticus

31 Dec 2024·Human Vaccines & Immunotherapeutics

Expanded spectrum of varicella disease and the need for vaccination in India

Article

Author: Jeganathan, Seetha N ; Ranganathan, Lakshmi Narasimhan ; Vijayaraghavan, Shanthi ; Arumugam, Ilakkiya ; Srikanth, Padma ; Ramesh, Rithvik

Varicella vaccine was first licensed in Japan and South Korea in 1989 for use in healthy children and was introduced in US in 1995. So far, 29 countries have adopted varicella vaccine in their universal immunization program (UIP). No Asian country, India included, has adopted the varicella vaccine as part of their UIP. The extra-cutaneous sites for VZV diseases are central nervous system and gastrointestinal tract, the expanded disease spectrum includes vasculopathy, myelitis, inflammatory bowel disease, perforated ulcers, and gastritis. The actual disease burden of varicella is not known as most of the infected individuals may not visit the physician. The amplifiable VZV DNA will not always be detectable in cerebrospinal fluid (CSF) samples in protracted illnesses such as vasculopathies, but demonstrable anti-VZV IgG in CSF has diagnostic value. The World Health Organization (WHO) position paper 2014 recommends two doses of varicella and zoster vaccines in targeted population. In India, varicella vaccine is not included in the UIP due to the cost and the belief that lifelong immunity occurs following primary infection. The expanded spectrum of VZV disease and the mounting body of evidence, however, suggest the need for both varicella and zoster vaccines in routine immunization schedule.

20 Sep 2024·Medicine

Mechanism and future prospect of treatment of facial paralysis caused by herpes zoster virus infection with acupuncture combined with medicine: A review

Review

Author: Pan, Limin ; Hong, Zhibo ; Wang, Yusu ; Li, Yeyao ; Guan, Ruiqian

Herpes zoster virus infectious facial paralysis is caused by the reactivation and replication of varicella-zoster virus, which leads to herpetic inflammatory lesions, resulting in peripheral facial paralysis associated with herpes rash in the auricle and external ear, and vestibular cochlear dysfunction. It is also known as Ramsey-Hunter syndrome (Hunt syndrome). Facial paralysis caused by herpes zoster is difficult to cure due to its easy loss of treatment and mistreatment. Cause a greater burden on the patient’s body and mind. However, the treatment of Western medicine has lagged behind and there are many adverse reactions, which cannot be completely cured, and new alternatives are urgently needed. This article briefly reviews the advantages and disadvantages of modern medical treatment of Hunt syndrome. This paper expounds the unique ideas of traditional Chinese medicine in the treatment of Hunt syndrome from the perspectives of antiviral, antibacterial, improving blood circulation, protecting cardiovascular, cerebrovascular, and nerve. This article discusses the superiority of traditional Chinese medicine in the treatment of Hunt syndrome from 2 aspects of Chinese medicine therapy and acupuncture therapy, and points out the feasibility of combined treatment of acupuncture and traditional Chinese medicine. So as to provide a new treatment for Hunt syndrome.

01 Sep 2024·Journal of Public Health

Impact on online research on celebrities’ uncommon diseases: the curious case of Justin Bieber and Ramsay Hunt syndrome

Article

Author: Santangelo, Omar Enzo ; Gianfredi, Vincenza ; Provenzano, Sandro

AimWe investigated how to use Internet user searches to gauge the impact of a celebrity illness on global public interest.MethodsThe study design is cross-sectional. Data on Internet searches were obtained from Google Trends (GT) for the period between 2017-2022 using the search words "Ramsay Hunt syndrome" (RHS), "Ramsay Hunt syndrome type 2," "Herpes zoster," and "Justin Bieber." The frequency of specific page views for "Ramsay Hunt syndrome," "Ramsay Hunt syndrome type 1," Ramsay Hunt syndrome type 2," Ramsay Hunt syndrome type 3," "Herpes zoster," and "Justin Bieber" were collected via a Wikipedia analysis tool that shows the number of times a specific page is viewed. Statistical analyses were performed using the Pearson (r) and Spearman's rank correlation coefficient (rho).ResultsGT data, in 2022, show a strong correlation for Justin Bieber and RHS or RHS type 2 (r = 0.75); similarly, Wikipedia data show a strong correlation for Justin Bieber and the others explored terms (r > 0.75). Furthermore, the correlation was strong between GT and Wikipedia for RHS (rho = 0.89) and RHS type 2 (rho = 0.88).ConclusionsThe peak search times for the GT and Wikipedia pages were during the same period. Useful new tools and analyses of Internet traffic data may be effective in assessing the impact of announced celebrity uncommon illnesses on global public interest.

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