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Last update 23 Jan 2025

Potassium Deficiency

Last update 23 Jan 2025

Basic Info

Synonyms

Deficiencies, Potassium, Deficiency, Potassium, K deficiency

+ [20]

Introduction

A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)

Drugs associated with Potassium Deficiency

Potassium Chloride

Target-

Mechanism-

Active Org.

Upsher-Smith Laboratories LLC [+4]

Originator Org.

Eli Lilly & Co.

Active Indication

Potassium Deficiency [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date06 Mar 1970

Clinical Trials associated with Potassium Deficiency

NCT05975632

/ RecruitingNot Applicable

GAMMA Study: Patient Self-testing of Capillary Blood Potassium: A Validation Study and Measurement Performance in Patients.

Multicentre, open, prospective and interventional study investigating the CardioRenal device in capillary blood of patients.It will be conducted at multiple investigational sites.

Start Date02 Aug 2023

Sponsor / Collaborator

CardioRenal

NCT04907773

/ CompletedNot Applicable

Evaluation of a Blood Potassium Measurement Device From Capillary Samples

This is an open, prospective, and interventional study investigating the potassium measurement with the CardioRenal device in capillary blood. It will be conducted at one investigational site.
Each subject will have capillary blood collections. Additionally as a reference a venous blood collection will be conducted

Start Date01 Jul 2021

Sponsor / Collaborator

CardioRenal

NCT05385640

/ CompletedNot ApplicableIIT

Serum Potassium as a Predictor of Clinical Outcomes in an Older Patient Cohort With Chronic Postsurgical Pain: Retrospective Analysis of A Multi-Center Prospective Database in China

Perioperative serum potassium in patients over 65 impacts recovery, quality of life and physical functioning. While perioperative serum potassium is an important preoperative risk factor for poor surgical outcomes in older adults, the relationship between perioperative serum potassium and postsurgical pain in this population has not been investigated. The investigators hypothesized that preoperative serum potassium would be associated with greater odds of postsurgical chronic pain.

Start Date01 Apr 2020

Sponsor / Collaborator

Chinese People's Liberation Army General Hospital

[+6]

100 Clinical Results associated with Potassium Deficiency

100 Translational Medicine associated with Potassium Deficiency

0 Patents (Medical) associated with Potassium Deficiency

1,118

Literatures (Medical) associated with Potassium Deficiency

01 Mar 2025·Genes & Diseases

Melatonin ameliorates Slc26a2-associated chondrodysplasias by attenuating endoplasmic reticulum stress and apoptosis of chondrocytes

Article

Author: Luo, Zhuojing ; Jie, Qiang ; Hao, Xue ; Zheng, Chao ; Yang, Liu ; Zhao, Chengxiang ; Lu, Weiguang ; Hu, Jingyan ; Wang, Dong ; Li, Pan

Although the pathogenesis and mechanism of congenital skeletal dysplasia are better understood, progress in drug development and intervention research remains limited. Here we report that melatonin treatment elicits a mitigating effect on skeletal abnormalities caused by SLC26A2 deficiency. In addition to our previous finding of endoplasmic reticulum stress upon SLC26A2 deficiency, we found calcium (Ca²⁺) overload jointly contributed to SLC26A2-associated chondrodysplasias. Continuous endoplasmic reticulum stress and cytosolic Ca²⁺ overload in turn triggered apoptosis of growth plate chondrocytes. Melatonin, known for its anti-oxidant and anti-inflammatory properties, emerged as a promising therapeutic approach in our study, which enhanced survival, proliferation, and maturation of chondrocytes by attenuating endoplasmic reticulum stress and Ca²⁺ overload. Our findings not only demonstrated the efficacy of melatonin in ameliorating abnormal function and cell fate of SLC26A2-deficient chondrocytes in vitro but also underscored its role in partially alleviating the skeletal dysplasia seen in Col2a1-CreER ^T2 ; Slc26a2 ^fl/fl mice. As revealed by histology and micro-CT analyses, melatonin significantly improved retarded cartilage growth, defective trabecular bone formation, and tibial genu varum in vivo. Collectively, these data shed translational insights for drug development and support melatonin as a potential treatment for SLC26A2-related chondrodysplasias.

01 Dec 2024·Resuscitation

Potassium disorders at intensive care unit admission and functional outcomes after cardiac arrest

Article

Author: Taccone, Fabio Silvio ; Hans, Kirkegaard ; Cariou, Alain ; Jean Baptiste, Lascarrou ; Laitio, Timo ; Skrifvars Markus, B. ; Søreide, Eldar ; Timo, Laitio ; B Skrifvars, Markus ; Alain, Cariou ; Eldar, Søreide ; Kirkegaard, Hans ; Mitja, Lääperi ; Reinikainen, Matti ; Lääperi, Mitja ; Holm, Aki ; Fabio Silvio, Taccone ; Aki, Holm ; Lascarrou, Jean Baptiste ; Matti, Reinikainen

BACKGROUNDAbnormal serum potassium levels are commonly found in the intensive care unit (ICU) population. We aimed to determine the prevalence of potassium disorders at ICU admission and its association with functional outcomes in comatose patients resuscitated from cardiac arrest.METHODSWe performed a post hoc analysis of pooled data from four randomised clinical trials involving comatose post-cardiac arrest patients admitted to ICU after return of spontaneous circulation (ROSC). Reference serum potassium levels were defined as between 3.0 and 4.9 mmol/L. An unfavourable functional outcome was defined as a cerebral performance category of 3 to 5 at 180 days. We compared potassium disturbances categorically in a mixed effects logistic regression model including initial rhythm, delay from collapse to return of spontaneous circulation, bystander cardiopulmonary resuscitation, lactate and urea at ICU admission, with normokalaemia set as the reference group.RESULTSWe included 1133 patients (557 from the HYPERION, 346 from the TTH48, 120 from the COMACARE, and 110 from the Xe-HYPOTHECA trials) with a median age of 64 years (interquartile range 55-72) and a predominance of males (72 %); a total of 712 (64 %) patients had unfavourable functional outcomes. On admission, 221 patients (19.5 %) experienced hyperkalaemia and 35 (3.1 %) patients experienced hypokalaemia. Fewer patients in the normokalaemia group (513/877, 58.5 %) had an unfavourable functional outcome compared to the hypokalaemia (24/35, 68.6 %) and hyperkalaemia groups (180/221, 81.4 %; p < 0.001). Hyperkalaemia was associated with higher odds for an unfavourable functional outcome (adjusted odds ratio (OR) 1.85, 95 % confidence interval (CI) 1.10-3.12, p = 0.02), while hypokalaemia was not (OR 1.36 95 % CI 0.51-3.60, p = 0.53). The associations were not significant in a subgroup analysis adjusted for the modified cardiac arrest hospital prognosis score in 833 patients (OR 1.74, 95 % CI 0.91-3.34, p = 0.10 for hyperkalaemia and OR 1.48, 95 % CI 0.40-5.44, p = 0.55 for hypokalaemia).CONCLUSIONSOf the comatose patients admitted to ICU after cardiac arrest, one in five experienced a potassium disorder on ICU admission. Hyperkalaemia was associated with unfavourable functional outcomes at 180 days, while hypokalaemia was not.

01 Dec 2024·Data in Brief

Dataset of infected date palm leaves for palm tree disease detection and classification

Article

Author: Alkhodre, Ahmad B ; Namoun, Abdallah ; Almoamari, Hani ; Sen, Adnan Ahmad Abi ; Alkhodre, Ahmad B. ; Alsaawy, Yazed

This article presents an image dataset of palm leaf diseases to aid the early identification and classification of date palm infections. The dataset contains images of 8 main types of disorders affecting date palm leaves, three of which are physiological, four are fungal, and one is caused by pests. Specifically, the collected samples exhibit symptoms and signs of potassium deficiency, manganese deficiency, magnesium deficiency, black scorch, leaf spots, fusarium wilt, rachis blight, and parlatoria blanchardi. Moreover, the dataset includes a baseline of healthy palm leaves. In total, 608 raw images were captured over a period of three months, coinciding with the autumn and spring seasons, from 10 real date farms in the Madinah region of Saudi Arabia. The images were captured using smartphones and an SLR camera, focusing mainly on inflected leaves and leaflets. Date palm fruits, trunks, and roots are beyond the focus of this dataset. The infected leaf images were filtered, cropped, augmented, and categorized into their disease classes. The resulting processed dataset comprises 3089 images. Our proposed dataset can be used to train classification deep learning models of infected date palm leaves, thus enabling the early prevention of palm tree-related diseases.

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