Klebsiella pneumoniae infection

Antibiotic resistance has reached such a pitch that it now poses a major global threat to people, public health, society and economies worldwide. As researchers report breakthrough on vaccine against MRSA bacteria, we look at which pharmas are working on vaccines to combat antimicrobial resistance Vaccine researchers are exploring a new approach to finding a solution to the problem of antibiotic-resistant bacteria. The experimental vaccine provided mice with high levels of immunity from lethal levels of MRSA bacteria staphylococcus aureus. The researchers’ work was detailed in the peer-reviewed scientific journal Nature Communications. The researchers were studying a particular type of carbohydrate molecule called PNAG, and were able to attach two versions of this to a virus that infects s. aureus bacteria. Importantly, the PNAG-virus combination had minimal negative impact on healthy bacteria living in the mice's intestines. The researchers noted that because PNAG is present in many different types of bacteria, it could be an attractive target for developing a vaccine. Such a vaccine is desperately needed. The overuse of antibiotics is behind the rise of so-called superbugs, like MRSA, that are resistant to most commonly available treatments. Antimicrobial resistance has reached such a pitch that it now poses a major global threat to people, public health, society and economies worldwide. As antibiotics become less effective, vaccines are an increasingly important tool to help reduce the spread of antibiotic resistance yet they are under-used for this purpose. Big pharmas working on vaccines to target bacteria However, several pharmaceutical companies are working on developing new vaccines to help combat antimicrobial resistance (AMR): Pfizer is developing vaccines targeting bacterial pathogens like staphylococcus aureus (skin and soft tissue infections), clostridium difficile (diarrhoea and colitis) and enterococcus faecium (urinary tract infections, intra-abdominal infections). GlaxoSmithKline is working on a vaccine candidate for Klebsiella pneumoniae (pneumonia). Merck is developing vaccines for staphylococcus aureus and Pseudomonas aeruginosa (hospital-acquired infections). Valneva is a biotechnology company developing a vaccine candidate for clostridium difficile Sanofi Pasteur , the vaccines division of French pharma company Sanofi, is working on a vaccine for staphylococcus aureus, including methicillin-resistant strains (MRSA). Moderna is exploring the use of its mRNA technology for AMR use. Its mRNA tech involves using molecules containing instructions to harness cells in the creation of vaccines against antibiotic-resistant bacteria like pseudomonas aeruginosa (chest infections) and acinetobacter baumannii (blood and wound infections) The World Health Organisation ’s Antimicrobial Resistance Division (ARD) says that making better use of existing vaccines is also vital in tackling antibiotic resistance and reducing preventable illness and deaths. The ARD says that if every child in the world were to receive a vaccine to protect them from infection with streptococcus pneumoniae bacteria (pneumonia, meningitis and middle ear infections) it would prevent an estimated 11 million days of antibiotic use each year. It also says that vaccines against viruses such as the flu also have a role to play, because people often take antibiotics unnecessarily when they have symptoms such as fever that can be caused by a virus.

LEXINGTON, Mass., Oct. 12, 2023 (GLOBE NEWSWIRE) -- T2 Biosystems, Inc. (NASDAQ:TTOO), a leader in the rapid detection of sepsis-causing pathogens and antibiotic resistance genes, today announced that it has submitted a 510(k) premarket notification to the U.S. Food and Drug Administration (FDA) to expand the number of pathogens detected on the FDA-cleared T2Bacteria® Panel to include the detection of Acinetobacter baumannii (A. baumannii). A. baumannii is a cause of bloodstream infections especially in critically ill patients, which can range from a benign transient bacteremia to septic shock. In a large study of nosocomial bloodstream infections, A. baumannii was the tenth most common pathogen and has a crude ICU mortality rate of 34.0% to 43.4%. A. baumannii infections typically occur in people in healthcare settings and pose risk to those who are on ventilators, have devices such as catheters, have open wounds from surgery, are in intensive care units, or have prolonged hospital stays. “We are excited about the potential to expand the number of pathogens detected by our FDA-cleared T2Bacteria Panel to include the detection of A. baumannii,” stated John Sperzel, Chairman and CEO of T2 Biosystems. “We believe the addition of A. baumannii will lead to increased adoption as it increases the detection capabilities of our FDA-cleared T2Bacteria Panel to approximately 75% of all sepsis-causing bacterial pathogens commonly found in blood stream infections.” Due to the emergence of pan-antibiotic resistant A. baumannii, the World Health Organization has identified A. baumannii as the most critically important bacteria that requires improved prevention and therapeutic approaches. There are few antimicrobial options for carbapenem resistant A. baumannii, which can increase mortality rates to 70%. Acinetobacter resistance to many antibiotics, including carbapenems, highlights the importance of rapid detection and targeted antimicrobial treatment. The T2Bacteria Panel is the first and only FDA-cleared product able to detect sepsis-causing pathogens directly in whole blood, in 3 to 5 hours, without the need to wait days for a positive blood culture. The FDA-cleared T2Bacteria Panel currently detects E. faecium, S. aureus, K. pneumoniae, P. aeruginosa, and E. coli, and the CE marked version detects the aforementioned pathogens plus A. baumannii. Rapid detection of these pathogens is essential to getting infected patients on the appropriate antimicrobial therapy and improving clinical outcomes. About T2 BiosystemsT2 Biosystems, a leader in the rapid detection of sepsis-causing pathogens and antibiotic resistance genes, is dedicated to improving patient care and reducing the cost of care by helping clinicians effectively treat patients faster than ever before. T2 Biosystems’ products include the T2Dx® Instrument, the T2Bacteria® Panel, the T2Candida® Panel, the T2Resistance® Panel, the T2Biothreat™ Panel, and the T2SARS-CoV-2™ Panel and are powered by the proprietary T2 Magnetic Resonance (T2MR®) technology. T2 Biosystems has an active pipeline of future products, including the expanded T2Bacteria Panel to add Acinetobacter baumannii, the Candida auris test, and the T2Lyme™ Panel, as well as next-generation products for the detection of bacterial and fungal pathogens and associated antimicrobial resistance markers. For more information, please visit www.t2biosystems.com. Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements regarding our ability to expand the number of pathogens detected by our FDA-cleared T2Bacteria Panel to include the detection of A. baumannii, including our ability to increase the detection capabilities of our FDA-cleared T2Bacteria Panel to approximately 75% of all sepsis-causing bacterial pathogens commonly found in blood stream infections, as well as statements that include the words “expect,” “may,” “should,” “anticipate,” and similar statements of a future or forward-looking nature. These forward-looking statements are based on management’s current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, (i) any inability to (a) realize anticipated benefits from commitments, contracts or products; (b) successfully execute strategic priorities; (c) bring products to market; (d) expand product usage or adoption; (e) obtain customer testimonials; (f) accurately predict growth assumptions; (g) realize anticipated revenues; (h) incur expected levels of operating expenses; or (i) increase the number of high-risk patients at customer facilities; (ii) failure of early data to predict eventual outcomes; (iii) failure to make or obtain anticipated FDA filings or clearances within expected time frames or at all; or (iv) the factors discussed under Item 1A. “Risk Factors” in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022, filed with the U.S. Securities and Exchange Commission, or SEC, on March 31, 2023, and other filings the Company makes with the SEC from time to time, including our Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. These and other important factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While the Company may elect to update such forward-looking statements at some point in the future, unless required by law, it disclaims any obligation to do so, even if subsequent events cause its views to change. Thus, no one should assume that the Company’s silence over time means that actual events are bearing out as expressed or implied in such forward-looking statements. These forward-looking statements should not be relied upon as representing the Company’s views as of any date subsequent to the date of this press release. Investor Contact:Philip Trip Taylor, Gilmartin Groupir@T2Biosystems.com 415-937-5406

Klebsiella pneumoniae is responsible for severe infections and stands out for its high resistance to antibiotics PHAXIAM's anti-Klebsiella pneumoniae phages to enter pre-clinical development to assess their efficacy in lung, blood and urinary tract infections, in addition to the three major targets already developed (S. aureus, P. aeruginosa, E. coli) PHAXIAM Therapeutics (Nasdaq & Euronext: FR0011471135), today announces the launch of a new preclinical development targeting a strong antimicrobial-resistant bacteria, Klebsiella pneumonia. Klebsiella pneumoniae (K. pneumoniae) causes a wide range of infections, including pneumonia, urinary tract infections, bacteremia and liver abscesses, and mainly infects immunocompromised people. However, the emergence and spread of hypervirulent and multi-resistant strains of this bacterium have recently extended its potential targets to people with no health problems. In Western countries, we estimate that between 3% and 5% of pneumonias are linked to an infection caused by K. pneumoniae. Worldwide, K. pneumoniae is responsible for 11.8% of hospital-acquired pneumonia. In high-risk patients (alcoholics and septicemics), the mortality rate associated with this kind of infection is between 50 and 100%1. The incidence of K. pneumoniae resistances is evaluated between 90-100,000 patients in the US and EU52, mainly in Urinary Tract infections and Respiratory Tract infections. Recent studies in Europe and the United States3,4 also revealed the existence of K. pneumoniae strains with an exceptionally high level of antimicrobial resistance, making them even more difficult to treat. The results of these studies demonstrated a worrying trend among the samples collected, which may even be resistant to enzyme-inhibiting antibiotics that have recently been developed but have not yet been marketed. This level of antimicrobial resistance in K. pneumoniae strains had never been observed before. Selected phages will be evaluated on a wide range of infections in which PHAXIAM already benefits from considerable expertise, such as lung, blood and urinary tract infections. This will enable the Company to capitalize on preclinical models validated with its three historical phage families, mutualize certain developments within the same indication and accelerate the progression to clinical phases. Thibaut du Fayet, Chief Executive Officer of PHAXIAM Therapeutics, stated: “With the launch of this new program, PHAXIAM Therapeutics deploys its strategy in line with the plan presented during the merger, and reaffirms its position at the forefront of the fight against antimicrobial resistance. K. pneumoniae bacteria represents a new target with a high medical need, affecting a large population worldwide, and for which antibiotics offer only a limited therapeutic solution. Our anti-Klebsiella phages will thus complement an already extended phage portfolio for the clinical indications we are targeting, and reinforce our ability to efficiently address a broad spectrum of resistant bacterial infections.” About PHAXIAM Therapeutics PHAXIAM is a biopharmaceutical company developing innovative treatments for resistant bacterial infections, which are responsible for many serious infections. The company is building on an innovative approach based on the use of phages, natural bacterial-killing viruses. PHAXIAM is developing a portfolio of phages targeting 3 of the most resistant and dangerous bacteria, which together account for more than two-thirds of resistant hospital-acquired infections: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. PHAXIAM is listed on the Nasdaq Global Select Market in the United States (ticker: PHXM – to be modified to a new symbol) and on the Euronext regulated market in Paris (ISIN code: FR0011471135, ticker: PHXM). PHAXIAM is part of the CAC Healthcare, CAC Pharma & Bio, CAC Mid & Small, CAC All Tradable, EnterNext PEA-PME 150 and Next Biotech indexes. 1 John V. Ashurst; Adam Dawson ET AL., 2022. 2 Five main European countries: France, Germany, UK, Spain & Italy 3 Highly multidrug-resistant Gram-negative bacterial infections in war victims in Ukraine, 2022; The Lancet Infectious Diseases 4 NIH investigates multidrug-resistant bacterium emerging in community settings; National Institutes of Health (NIH) The content above comes from the network. if any infringement, please contact us to modify.