Last update 01 Nov 2024

Firmicute infection

Last update 01 Nov 2024

Basic Info

Synonyms-

Introduction-

Drugs associated with Firmicute infection

SBX-301

Target

β-glucuronidase

Mechanism

β-glucuronidase inhibitors

Active Org.

Symberix, Inc.

Originator Org.

Symberix, Inc.

Active Indication

Firmicute infection [+1]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Firmicute infection

EUCTR2019-001419-21-FR / Unknown statusPhase 3IIT

Optimization of skin preparation to reduce Cutibacterium acnes colonization in superficial and deep samples during prosthetic shoulder surgery in male patients - OPRICA

Start Date16 Sep 2019

Sponsor / Collaborator

CHU de Nantes

100 Clinical Results associated with Firmicute infection

100 Translational Medicine associated with Firmicute infection

0 Patents (Medical) associated with Firmicute infection

Literatures (Medical) associated with Firmicute infection

01 Jan 1985·The Korean Journal of Parasitology

Studies on intestinal trematodes in Korea XVIII. Effects of praziquantel in the treatment of Fibricola seoulensis infection in albino rats

Article

Author: Seo, Byoug Seol ; Chai, Jong Yil ; Lee, Soon Hyung

The therapeutic effect of praziquantel on Fibricola seoulensis infection were studied by experimental infection of albino rats with the metacercariae obtained from the snakes. Total 51 albino rats were infected each with 500 or 1,000 metacercariae in number through intragastric tubes. One or four weeks later the rats were treated with 1, 5, 10 or 20 mg/kg sigle dose of praziquantel and sacrificed after 3 days or 10-120 minutes to search for the worms in their small intestine. The worms recovery rate at 3 days after the treatment was 10.7% in 1 mg/kg does group and 0.03~0.2% in 5, 10 and 20 mg/kg group, while that of untreated control was 51.3%. The minimum effective dose to treat F. seoulensis infection in the rats is considered to be 5 mg/kg in sigle dose. By observing the distribution pattern of worms in the small intestine after the treatment, dislodgment of the worms froms the duodenum, thier normal habitat, to the lower portion was recognizable within as early as 10 minutes. The majority of worms was found to have descended to the ileo-caecal portion after 60-120 minutes.

01 Jan 1983·The Korean Journal of Parasitology

Studies on intestinal trematodes in Korea IX. Recovery rate and development of Fibricola seoulensis in experimental animals

Article

Author: Hong, Sung Tae ; Chai, Jong Yil ; Seo, Byong Seol ; Hong, Sung Jong ; Lee, Soon Hyung

An experimental study was carried out to observe the susceptibility of several kinds of laboratory animals to Fibricola seoulensis infection, a diplostomatid fluke of mammals. The metacercariae were obtained from the viscera of the snakes, Natrix tigrina lateralis and 50-2,000 in number each was artificially fed to a total of 127 animals; albino rats, mice, dogs, cats, rabbits and chickens. After 3 days to 8 weeks the animals were sacrificed and the recovery rate of worms as well as their maturity was observed. The results are as follows: The overall wom recovery rates throughout the experimental period was highest in albino rats(40.0 %) followed by mice(33.9%), cats(20.9 %), dogs(11.4 %), rabbits(0.05 %) and chickens(0 %). However, the recovery rates in the same host decreased as infection progressed longer and variable by the amount of metacercariae given. From albino rats and mice, the highest recovery rates were obtained in 1,000 and 200 metacercariae infection groups repectively, and it is considerd that such amount should be the optimum dose for experimental infection of these animals. The main location of F. seoulensis in experimental animals was small intestine especially the duodenum. The maturity index (No. mature worms/No. examined) was 100% in albino rats and mice, while only 22.7% or 0% in dogs or cats respectively. From the results, it is concluded that albino rats and mice are the most susceptible hosts for F. seoulensis infection among six kinds of laboratory animals examined.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Firmicute infection

Basic Info

Related

Analysis