Last update 01 Nov 2024

Trimethylaminuria

Last update 01 Nov 2024

Basic Info

Synonyms

FISH-ODOR SYNDROME, Fish malodor syndrome, Fish odor syndrome

+ [16]

Introduction

Increased concentration of trimethylamine in the urine. [https://orcid.org/0000-0002-0736-9199]

Drugs associated with Trimethylaminuria

TST-004

Target

MASP2

Mechanism

MASP2 inhibitors

Active Org.

Transcenta Therapeutics Co., Limited

Originator Org.

Suzhou Chuangsheng Pharmaceutical Group Co., Ltd.

Active Indication

Glomerulonephritis, IGA [+2]

Inactive Indication-

Drug Highest PhasePhase 1

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

WS019

Target-

Mechanism-

Active Org.

Waterstone Pharmaceuticals (Wuhan) Co., Ltd.

Originator Org.

Waterstone Pharmaceuticals (Wuhan) Co., Ltd.

Active Indication

Trimethylaminuria

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Trimethylaminuria

NCT04473404 / CompletedNot Applicable

Evaluation of the Effect of an Oral Probiotic on Oral Bacteria and Malodor

The purpose of this study is to evaluate the effects of consuming a probiotic on salivary, plaque, and tongue bacteria, as well as oral malodor (bad breath). Healthy volunteers will consume a probiotic powder, or a placebo powder, that is dissolved in water for 4 weeks.

Start Date20 Jul 2020

Sponsor / Collaborator

Dose Biosystems Inc.

NL-OMON44360 / CompletedNot Applicable

Exploration of the modulation of skin microbiota and odor components by introduction of stress in healthy male subjects. - MOIST

Start Date31 Oct 2017

Sponsor / Collaborator

Procter & Gamble Co.

ChiCTR-ROC-17011595 / SuspendedIIT

Relationship between genetic polymorphism and susceptibility to trimethylaminuria

Start Date30 Jun 2017

Sponsor / Collaborator

Xiangya Hospital Central South University

100 Clinical Results associated with Trimethylaminuria

100 Translational Medicine associated with Trimethylaminuria

0 Patents (Medical) associated with Trimethylaminuria

238

Literatures (Medical) associated with Trimethylaminuria

05 Aug 2024·The Kobe journal of medical sciences

A Japanese Case of Food Protein-induced Enterocolitis Syndrome Caused by Multiple Seafoods.

Article

Author: Ozawa, Kyoko ; Yamamura, Saeko ; Satou, Taiki ; Tawaza, Seiichi ; Asada, Hiroshi ; Tanaka, Yoshiko ; Takahashi, Akari

Food protein-induced enterocolitis syndrome (FPIES) caused by fish and others is prevalent in the Mediterranean regions but is less frequently reported in Japan. This case report describes a 3-year-old Japanese girl who developed FPIES triggered by multiple seafoods, including swordfish, cod, and squid. The diagnosis was confirmed through oral food challenge tests (OFC), which led to repeated vomiting and an increase in thymus and activation-regulated chemokine (TARC) levels. This case highlights the importance of considering fish-induced FPIES in the differential diagnosis of recurrent vomiting in children and suggests the potential utility of TARC levels in diagnosing and monitoring FPIES.

01 Apr 2024·Drug Metabolism and Pharmacokinetics

Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources

Article

Author: Hishinuma, Eiji ; Yamazaki, Hiroshi ; Shimizu, Makiko ; Hiratsuka, Masahiro ; Makiguchi, Miaki ; Saito, Sakae

Genetic variants of human flavin-containing monooxygenase 3 (FMO3) were investigated using an updated Japanese population panel containing 54,000 subjects (the previous panel contained 38,000 subjects). One stop codon mutation and six amino acid-substituted FMO3 variants were newly identified in the updated databank. Of these, two substituted variants (p.Thr329Ala and p.Arg492Trp) were previously identified in compound haplotypes with p.[(Glu158Lys; Glu308Gly)] and were associated with the metabolic disorder trimethylaminuria. Three recombinant FMO3 protein variants (p.Ser137Leu, p.Ala334Val, and p.Ile426Val) expressed in bacterial membranes had similar activities toward trimethylamine N-oxygenation (∼75-125 %) as wild-type FMO3 (117 min^-1); however, the recombinant novel FMO3 variant Phe313Ile showed moderately decreased FMO3 catalytic activity (∼20 % of wild-type). Because of the known deleterious effects of FMO3 C-terminal stop codons, the novel truncated FMO3 Gly184Ter variant was suspected to be inactive. To easily identify the four impaired FMO3 variants (one stop codon mutation and three amino-acid substitutions) in the clinical setting, simple confirmation methods for these FMO3 variants are proposed using polymerase chain reaction/restriction fragment length polymorphism or allele-specific PCR methods. The updated whole-genome sequence data and kinetic analyses revealed that four of the seven single-nucleotide nonsense or missense FMO3 variants had moderately or severely impaired activity toward trimethylamine N-oxygenation.

01 Feb 2024·Chemosphere

Identification of odor-causing compounds in six species of odor-producing microalgae separated from drinking water source with distinct fishy odor: Insight into microalgae growth and odor characteristics

Article

Author: Liang, Feng ; Wang, Ling ; Li, Zhaoxia ; Ding, Cheng ; Li, Dasheng ; Liu, Dunxi ; Wang, Chunmiao ; Ma, Weixing ; Yu, Jianwei ; Meng, Qingqin ; Chen, Xiao ; Guo, Qingyuan

Fishy odor, as an offensive and unpleasant odor, could occur in drinking water source with poor nutrition, it is usually considered to be associated with odor-producing microalgae. However, the specific relations among fishy odor, fishy odorants and responsible microalgae were not elucidated comprehensively. In this paper, the odor-causing compounds generated from six microalgae with fishy odor characteristic, isolated in drinking water source Tongyu River, were identified simultaneously. The sensory evaluation result indicated that Tongyu River was principally related to fishy odor (odor intensity 6.5-7.6). Correspondingly, seven, nine, seven, six, seven and seven olfactory detection peaks (ODP) were screened by combining data of GC/O/MS and GC/GC/TOFMS in Cyclotella, Cryptomonas ovate, Melosira, Dinobryon sp., Synedra and Ochromonas sp., which were isolated in Tongyu River and cultured in laboratory. Totally twenty odor-causing compounds, including hexanal, 2-hexenal, 3-hexen-1-ol, heptanal, 1-octen-3-one, 2,4-heptadienal, 2-tetradecanone, 3,5-octadien-2-one, octanal, 1-octen-3-ol, 2-octenal, nonanal, 2,4-octadienal, 2-nonenal, decanal, 2,6-nonadienal, 2-decenal, undecanal, 2,4-decadienal and dodecanal, were screened and identified in all isolated microalgae. Additionally, fishy odor intensity for all identified microalgae increased obviously as microalgae cell number increased and microalgae cell ruptured in cultivation cycles through pearson and spearman correlation analysis. For the first time, twenty odor-causing compounds associating with fishy odor were recognized from six isolated microalgae, which would provide more scientific basis and theoretical support for preventing and treating fishy odor episode of drinking water source.

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Trimethylaminuria

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