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Last update 08 May 2025

Teratoma, Testicular

Last update 08 May 2025

Basic Info

Synonyms

TERATOMA, TESTICULAR, TESTICULAR TERATOMA, TESTIS, TERATOMA

+ [23]

Introduction

A non-seminomatous germ cell tumor arising from the testis. It is characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). Testicular teratomas in children follow a benign clinical course whereas in postpubertal patients may metastasize to other anatomic sites.

Drugs associated with Teratoma, Testicular

Ipilimumab

Target

CTLA4

Mechanism

CTLA4 inhibitors

Active Org.

Bristol Myers Squibb Co. [+12]

Originator Org.

Bristol Myers Squibb Co.

Active Indication

Advanced Hepatocellular Carcinoma [+305]

Inactive Indication

Acute lymphoblastic leukemia recurrent [+98]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

United States

First Approval Date25 Mar 2011

Clinical Trials associated with Teratoma, Testicular

JPRN-UMIN000054107

/ RecruitingNot ApplicableIIT

A trial to evaluate the feasibility of using radio-controlled miniature cars to reduce preoperative anxiety in children. - A trial to evaluate the feasibility of using radio-controlled miniature cars to reduce preoperative anxiety in children.

Start Date20 Mar 2024

Sponsor / Collaborator

Kyushu University

JPRN-jRCTs031180410

/ RecruitingPhase 3IIT

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors; AGCT1531

Start Date22 May 2020

Sponsor / Collaborator-

NCT01434355

/ CompletedNot ApplicableIIT

Molecular Epidemiology of Pediatric Germ Cell Tumors

This research trial studies deoxyribonucleic acid (DNA) samples from younger patients with germ cell tumor and their parents or siblings. Studying samples of tumor tissue and saliva from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

Start Date01 Nov 2011

Sponsor / Collaborator

The Children's Oncology Group Foundation, Inc.

[+1]

100 Clinical Results associated with Teratoma, Testicular

100 Translational Medicine associated with Teratoma, Testicular

0 Patents (Medical) associated with Teratoma, Testicular

747

Literatures (Medical) associated with Teratoma, Testicular

01 Jan 2025·BMJ Case Reports

Spigelian hernia and cryptorchidism syndrome: open spigelian hernia repair and laparoscopic one-stage orchiopexy for ectopic testis

Article

Author: Ablatt, Saniya ; Escobar, Mauricio Antonio

Spigelian hernia and cryptorchidism syndrome in children is increasingly reported in the literature. A variety of phenotypes have been reported, so diagnostic approaches and operative techniques remain poorly defined. The case of an infant male who presented with a left spigelian hernia and ipsilateral cryptorchidism who was initially misdiagnosed with an ectopic inguinal testis is presented. He underwent diagnostic laparoscopy which revealed an ectopic left testis within the spigelian hernia defect with a gubernaculum present. Collaborative decision making between paediatric surgery and paediatric urology resulted in the final operative repair entailing laparoscopic orchiopexy, open left spigelian and inguinal hernia repair, right inguinal hernia repair and umbilical hernia repair. We conclude that a laparoscopic orchiopexy of an ectopic testis within a spigelian hernia is a safe method to address this rare phenomenon, but collaborative multidisciplinary discussion is ideal to weigh operative strategies and management.

01 Jan 2025·IJU Case Reports

Total en bloc spondylectomy in testicular immature teratoma: Long‐term survival amidst vertebral metastasis escalated by growing teratoma syndrome

Article

Author: Ito, Noriyuki ; Maruno, Kouhei ; Tamaki, Masahiro ; Kikkawa, Kazuro ; Nakashima, Masakazu ; Yamada, Yuya ; Takahashi, Toshifumi ; Hazama, Tatsuya

IntroductionWe present a rare case of long‐term survival following metastasectomy for lumbar metastasis with growing teratoma syndrome.Case presentationAn 18‐year‐old man presented with left scrotal mass and lumbago. Alpha‐fetoprotein was elevated to 648.8 ng/mL, while human chorionic gonadotropin and lactate hydrogenase were normal. Pathology of left inguinal orchiectomy revealed immature teratoma, and computed tomography confirmed a single metastasis in the second lumbar vertebra. After two courses of bleomycin, etoposide, cisplatin chemotherapy, alpha‐fetoprotein decreased, but computed tomography confirmed an enlarged lumbar metastasis. A vertebral biopsy demonstrated teratoma with a dominant mature component, and growing teratoma syndrome was suspected. Following additional etoposide, cisplatin chemotherapy, and normalization of alfa‐fetoprotein, total spondylectomy was performed. Vertebral pathology proved mature teratoma. After adjuvant chemotherapy, he has been recurrence‐free for 17 years.ConclusionSpondylectomy of a single metastatic vertebra contributed to long‐term survival in a testicular teratoma case.

01 Dec 2024·Journal of Cancer Research and Therapeutics

Characteristics and prognosis of testicular mixed teratoma and seminoma

Article

Author: Li, Kai ; Fan, Caibin ; Sun, Fengdan

ABSTRACTBackground:To evaluate the association of demographic and clinicopathological characteristics with the survival of patients with testicular mixed teratoma and seminoma (TMTS).Methods:The data of 3296 eligible patients with TMTS who underwent surgery between 2010 and 2015 were obtained from the Surveillance, Epidemiology, and End Results database. Overall survival (OS) and cancer-specific survival (CSS) were determined using the Kaplan–Meier survival curves. The association of demographic and clinicopathological characteristics with the OS and CSS of patients with TMTS was assessed using the Cox proportional hazard regression model.Results:The number of patients with TMTS increased annually. In Kaplan–Meier analyses, TMTS patients with advanced T stage (P < 0.001 for OS and P < 0.001 for CSS), lymph node metastasis (P < 0.001 for OS and P < 0.001 for CSS), distant metastasis (P < 0.001 for OS and P < 0.001 for CSS), no regional lymph node resection (P = 0.003 for OS and P = 0.002 for CSS), large tumor size (P = 0.001 for OS and P = 0.001 for CSS), and LVI (P < 0.001 for OS and P < 0.001 for CSS) exhibited inferior OS and CSS. Moreover, distant metastasis (HR 11.224, P < 0.001; HR 15.817, P < 0.001) and regional lymph node resection (HR 0.425, P = 0.003; HR 0.366, P = 0.004) were identified as independent prognostic factors for OS and CSS in patients with TMTS through multivariable analyses.Conclusions:Distant metastasis and lymph node metastasis were deemed important prognostic factors for OS and CSS in patients with TMTS. Therefore, a comprehensive understanding and clinical assessments of these prognostic factors are necessary before tailoring clinical management and treatment plan specified for patients with TMTS.

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Teratoma, Testicular

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