RegulationConditional marketing approval (CN), Orphan Drug (JP), Fast Track (US), Priority Review (AU), Breakthrough Therapy (US), Accelerated Approval (US)

Gene Sequence

Sequence Code 143797L

Source: *****

Sequence Code 9060585H

Source: *****

880

Clinical Trials associated with Ipilimumab

NCT06632327 / Not yet recruitingPhase 3IIT

Perioperative Versus Adjuvant Systemic Therapy in Patients With Resectable Non-Small Cell Lung Cancer - PROSPECT LUNG

This phase III trial compares standard therapy given after surgery (adjuvant) to standard therapy given before and after surgery (perioperative) in treating patients with stage II-IIIB non-small cell lung cancer (NSCLC) that can be removed by surgery (resectable). The usual approach for patients with resectable NSCLC is chemotherapy and/or immunotherapy before surgery, after surgery, or both before and after surgery. This study is being done to find out which approach is better at treating patients with lung cancer. Treatment will be administered according to the current standard of care at the time of enrollment. Chemotherapy options may include cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and vinorelbine at standard doses according to the treating physician. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make deoxyribonucleic acid (DNA) and may kill tumor cells. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill tumor cells. Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Other chemotherapy drugs, such as vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading . Immunotherapy with monoclonal antibodies, such as nivolumab, pembrolizumab, and atezolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with chemotherapy and immunotherapy prior to surgery and continuing treatment after surgery may be a more effective treatment option than adjuvant therapy alone in patients with stage II-IIIB resectable NSCLC.

Start Date30 May 2025

Sponsor / Collaborator

Alliance for Clinical Trials in Oncology

[+1]

NCT06683755 / Not yet recruitingPhase 1/2IIT

Phase I/IIa Dose Finding Study of Triplet Regimen of Relatlimab Ipilimumab and NIvolumab in First Line Therapy of Metastatic Melanoma (TRINITY)

To determine the recommended Phase IIa dose (RP2D) of the triplet combination.
To determine the safety and efficacy of the combination at the RP2D.

Start Date01 May 2025

Sponsor / Collaborator

The University of Texas MD Anderson Cancer Center

NCT06364917 / Not yet recruitingPhase 2IIT

DISCERN: Dual Immune Strategy Versus Single Checkpoint Inhibition Efficacy Response in PDL-1 Negative Non-Small Cell Lung Cancer (NSCLC)

The purpose of this study, known as DISCERN, is to compare two different treatments for a type of lung cancer called non-small cell lung cancer (NSCLC) that does not show a marker known as PD-L1. This study will help us understand if using two types of immune therapy together with chemotherapy is better than using one type of immune therapy with chemotherapy. We're doing this by looking at changes in the subject's cancer's DNA in the blood after starting treatment.

Start Date31 Jan 2025

Sponsor / Collaborator

The University of Alabama at Birmingham

100 Clinical Results associated with Ipilimumab

100 Translational Medicine associated with Ipilimumab

100 Patents (Medical) associated with Ipilimumab

5,230

Literatures (Medical) associated with Ipilimumab

31 Dec 2024·OncoImmunology

Distinct autoantibody profiles across checkpoint inhibitor types and toxicities

Article

Author: Gerber, David E. ; von Itzstein, Mitchell S. ; Mu-Mosley, Hong ; Park, Jason Y. ; Diefenbach, Catherine S. ; Zhu, Chengsong ; Fattah, Farjana ; Liu, Jialiang ; Wakeland, Edward K. ; Kahl, Brad S. ; Xie, Yang

Immune checkpoint inhibitors (ICI) are increasingly used in combination. To understand the effects of different ICI categories, we characterized changes in circulating autoantibodies in patients enrolled in the E4412 trial (NCT01896999) of brentuximab vedotin (BV) plus ipilimumab, BV plus nivolumab, or BV plus ipilimumab-nivolumab for Hodgkin Lymphoma. Cycle 2 Day 1 (C2D1) autoantibody levels were compared to pre-treatment baseline. Across 112 autoantibodies tested, we generally observed increases in ipilimumab-containing regimens, with decreases noted in the nivolumab arm. Among 15 autoantibodies with significant changes at C2D1, all nivolumab cases exhibited decreases, with more than 90% of ipilimumab-exposed cases showing increases. Autoantibody profiles also showed differences according to immune-related adverse event (irAE) type, with rash generally featuring increases and liver toxicity demonstrating decreases. We conclude that dynamic autoantibody profiles may differ according to ICI category and irAE type. These findings may have relevance to clinical monitoring and irAE treatment.

31 Dec 2024·Cancer Biology & Therapy

Understanding and overcoming resistance to immunotherapy in genitourinary cancers

Review

Author: Jansen, Caroline S ; Evans, Sean T ; Bilen, Mehmet Asim ; Jani, Yash ; Yildirim, Ahmet ; Kalemoglu, Ecem

The introduction of novel immunotherapies has significantly transformed the treatment landscape of genitourinary (GU) cancers, even becoming the standard of care in some settings. One such type of immunotherapy, immune checkpoint inhibitors (ICIs) like nivolumab, ipilimumab, pembrolizumab, and atezolizumab play a pivotal role by disturbing signaling pathways that limit the immune system's ability to fight tumor cells. Despite the profound impact of these treatments, not all tumors are responsive. Recent research efforts have been focused on understanding how cancer cells manage to evade the immune response and identifying the possible mechanisms behind resistance to immunotherapy. In response, ICIs are being combined with other treatments to reduce resistance and attack cancer cells through multiple cellular pathways. Additionally, novel, targeted strategies are currently being investigated to develop innovative methods of overcoming resistance and treatment failure. This article presents a comprehensive overview of the mechanisms of immunotherapy resistance in GU cancers as currently described in the literature. It explores studies that have identified genetic markers, cytokines, and proteins that may predict resistance or response to immunotherapy. Additionally, we review current efforts to overcome this resistance, which include combination ICIs and sequential therapies, novel insights into the host immune profile, and new targeted therapies. Various approaches that combine immunotherapy with chemotherapy, targeted therapy, vaccines, and radiation have been studied in an effort to more effectively overcome resistance to immunotherapy. While each of these combination therapies has shown some efficacy in clinical trials, a deeper understanding of the immune system's role underscores the potential of novel targeted therapies as a particularly promising area of current research. Currently, several targeted agents are in development, along with the identification of key immune mediators involved in immunotherapy resistance. Further research is necessary to identify predictors of response.

10 Dec 2024·Neurology

Immune Checkpoint Inhibitor Myopathy

Review

Author: Mammen, Andrew L. ; Beecher, Grayson ; Pinal-Fernandez, Iago ; Liewluck, Teerin

Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of several malignancies, with improved survival. These monoclonal antibodies target immune checkpoints, including cytotoxic T-lymphocyte-associated protein 4 (ipilimumab and tremelimumab), programmed death 1 (nivolumab, pembrolizumab, cemiplimab, and dostarlimab), programmed death ligand 1 (atezolizumab, avelumab, and durvalumab), and lymphocyte activation gene 3 (relatlimab), and effectively augment the immune response against tumor cells. Releasing the brakes on the immune system has consequences, however, in the form of immune-related adverse events (irAEs), which may affect any organ. Neurologic irAEs represent 1%-3% of all irAEs, with immune-mediated myopathy (ICI myopathy) being the most common manifestation. Recent large patient series and systematic reviews have established the key features and highlighted new insights into ICI myopathy. ICI myopathy is characterized by an acute or subacute onset of oculobulbar and/or proximal limb weakness, with or without associated respiratory insufficiency and myocarditis. Creatine kinase elevation is common. Oculobulbar presentations with or without respiratory failure may be misattributed to neuromuscular junction disorders, particularly because acetylcholine receptor antibodies are present in up to 40% of patients; however, an electrodiagnostic evidence of a defect of neuromuscular transmission is often absent even in patients with severe weakness, highlighting that the myopathic process is the driving force behind these presentations. Muscle histopathology commonly demonstrates a unique signature of multifocal clusters of necrotic and regenerating fibers, differentiating ICI myopathy from other autoimmune myopathies. Transcriptomic analysis has uncovered distinct subgroups within ICI myopathy, revealing varying degrees of type 1 and type 2 interferon pathway activation alongside notable upregulation of the interleukin (IL)-6 pathway in affected muscle tissue. This discovery presents a promising avenue for intervention through the use of therapies that suppress the interferon pathway and target IL-6 or its receptor. Despite clinical improvements with immunomodulatory therapy, with corticosteroids the mainstay of treatment, mortality remains high, particularly in those with associated myocarditis or respiratory failure requiring intubation, where mortality occurs in up to 50%. ICI withdrawal can lead to cancer progression and death, highlighting a need for improved approaches to ICI rechallenge, performed in limited patients with variable success to date.

861

News (Medical) associated with Ipilimumab

18 Nov 2024

·www.globenewswire.com

Immatics Announces Third Quarter 2024 Financial Results, Business Update and First Clinical Data on TCER® IMA402 Targeting PRAME

The Company will now target five major cancer types with its four clinically active compounds across both TCR-T cell therapies and TCR-based Bispecifics Today, Company discloses first clinical data from the TCR Bispecific molecule, TCER® IMA402 targeting PRAME, in the Phase 1 dose escalation trial, demonstrating a favorable tolerability profile and signs of dose-dependent and PRAME expression-dependent clinical activity, including first objective responses in melanoma patients; early pharmacokinetics data indicate a median half-life of 7 days, potentially enabling bi-weekly dosing; dose escalation is ongoingSUPRAME, the randomized-controlled Phase 3 trial to evaluate ACTengine® IMA203 in 2L+ metastatic melanoma patients, planned to commence in December 2024; pre-specified interim data analysis planned for early 2026Recently, Company presented Phase 1b clinical data on ACTengine® IMA203 targeting PRAME that demonstrate deep and durable responses in heavily pretreated metastatic melanoma patients treated at RP2D; IMA203 continues to maintain a favorable tolerability profile in patients treated across all dose levelsNext-generation ACTengine® IMA203CD8 Phase 1a dose escalation data demonstrate enhanced pharmacology and potency per cell; TCR-T candidate to be evaluated for future development in solid cancers with medium-level PRAME copy numbers, such as ovarian and endometrial cancerClinical proof-of-concept data from the ongoing Phase 1 dose escalation trial with TCER® IMA401 targeting MAGEA4/8 demonstrate initial clinical anti-tumor activity in multiple tumor types and a manageable tolerability profile; dose escalation is ongoing$150 million public offering completed on October 15, 2024As of September 30, 2024, cash and cash equivalents as well as other financial assets amount to $549.2 million1 (€490.5 million), not including the cash inflow from the public offering on October 15, 2024; updated cash reach guidance into 2H 2027 Houston, Texas and Tuebingen, Germany, November 18, 2024 – Immatics N.V. (NASDAQ: IMTX, “Immatics” or the “Company”), a clinical-stage biopharmaceutical company active in the discovery and development of T cell-redirecting cancer immunotherapies, today provided a business update and reported financial results for the quarter ended September 30, 2024. The Company also reported the first clinical data update from the ongoing Phase 1 dose escalation trial evaluating its next-generation, half-life extended TCR Bispecific molecule, TCER® IMA402 targeting PRAME. “This year, Immatics has demonstrated the strength of its pipeline by announcing data on clinical activity for its four clinical-stage assets across two therapeutic modalities. These include ACTengine® IMA203 targeting PRAME positioned in 2L+ melanoma now moving forward into the Phase 3 trial SUPRAME targeting BLA filing in early 2027; ACTengine® IMA203CD8 targeting hard-to-treat solid cancers with an initial focus on ovarian and endometrial cancers; and TCER® IMA401 targeting MAGEA4/8 demonstrating clinical proof-of-concept during dose escalation and positioned in squamous NSCLC and head and neck cancer. Today, we are very pleased to announce first clinical data on TCER® IMA402 targeting PRAME, which show promising signals of anti-tumor activity during early dose escalation and is initially positioned in 1L+ melanoma,” said Harpreet Singh, Ph.D., CEO and Co-Founder of Immatics. “With our enhanced cash runway into the second half of 2027, Immatics is well positioned to advance all four candidates to highly relevant value inflection points with a specific focus on delivering meaningful clinical signals in multiple solid cancers in the coming year.” Third Quarter 2024 and Subsequent Company Progress TCR Bispecifics Programs TCER® IMA402 (PRAME) Today, Immatics is providing the first clinical data update from the ongoing Phase 1 dose escalation trial evaluating its next-generation, half-life extended TCR Bispecific molecule, TCER® IMA402 targeting PRAME. Patient Population: As of the data cut-off on November 6, 2024, 33 heavily pretreated patients with recurrent and/or refractory solid tumors have been treated with a dose range from 0.02 mg to 4 mg of IMA402 monotherapy. The treated patient population is composed of patients with a median of three and a maximum of five lines of prior systemic treatments. The safety population includes all 33 patients treated with IMA402, of which 21 patients were evaluable for efficacy analysis and are PRAME-positive or were not tested for PRAME. Of these 21 patients, eight patients received at least one dose of IMA402 at dose level 7 (DL7, 3 mg), and one patient received IMA402 at dose level 8 (DL8, 4 mg). Based on preclinical in-vivo data, relevant anti-tumor efficacy was expected starting at ~3 mg human equivalent dose, which aligns with the initial clinical anti-tumor activity reported today. Safety: IMA402 demonstrated a favorable tolerability profile in the 33 patients treated. The most common treatment-related adverse events (AEs) were mostly mild to moderate cytokine release syndrome (CRS) and transient lymphopenia. Step dosing has been implemented and dose escalation is ongoing. The maximum tolerated dose has not yet been determined. Pharmacokinetics: Early pharmacokinetic data indicate a median half-life of approximately seven days, potentially enabling bi-weekly dosing. Initial Anti-Tumor Activity: Initial signs of clinical activity have been observed and are associated with PRAME expression and IMA402 dose levels administered. In the PRAME-negative patient population across all doses and indications, only one patient out of seven (14%) showed tumor shrinkage of -2.9%.In comparison, in the PRAME-positive or non-tested patients across all indications treated with low dose levels (DLs 1-6), tumor shrinkage was observed in 25% (3/12) of patients, including one unconfirmed partial response in a cutaneous melanoma patient. Nine patients with tumors that tested PRAME-positive or were not tested for PRAME received a relevant dose (8 patients at DL7 and 1 patient at DL8). 78% (7/9) thereof experienced shrinkage of their target lesions, including several patients with significant ongoing tumor shrinkage: one cutaneous melanoma patient with an ongoing (at 3 months post first dose at data cut-off) confirmed partial response with -40.2% tumor shrinkage treated at DL7;two patients with ongoing (at 6+ weeks and 8+ months) stable diseases with significant tumor shrinkage (-27.5% in a patient with cutaneous melanoma at DL8 and at first scan; -25% in a patient with uveal melanoma deepening over time and treated at escalating doses starting at DL4 and currently at DL7);one ovarian cancer patient with ongoing (at 3 months) stable disease and tumor shrinkage of -13% started at DL6 and currently at DL7. Early Signs of Clinical Activity Associated with PRAME Expression and IMA402 Dose *Patients who received DL7 or higher, either from start or as part of intra-patient dose-escalation; #continuing treatment; PD: Progressive Disease; SD: Stable Disease; PR: Partial Response; cPR: confirmed Partial Response; BOR: Best Overall Response; BL: Baseline; NT: not tested or not evaluable for PRAME expression More information and details on the IMA402 clinical data are available on the Events & Presentations page of the Immatics corporate website: https://investors.immatics.com/events-presentations Based on these initial signs of dose-dependent and PRAME target expression-dependent clinical activity observed during dose escalation, the Company will continue to evaluate IMA402 at higher dose levels to determine the optimal therapeutic dose. The next data update on IMA402 is planned for 2025. TCER® IMA401 (MAGEA4/8) On September 16, 2024, Immatics announced the proof-of-concept clinical data for the first candidate of its next-generation, half-life extended TCR Bispecifics platform, TCER® IMA401 (MAGEA4/8), during an oral presentation at the European Society for Medical Oncology (ESMO) Congress 2024. As of data cut-off on July 23, 2024, 35 heavily pretreated patients with recurrent and/or refractory solid tumors were treated with IMA401 monotherapy across nine escalating dose levels. The treated patient population was composed of patients with 16 different solid tumor indications who were both HLA-A*02:01 and MAGEA4/8-positive, had received a median of four and up to eight lines of prior systemic treatments and the majority had an ECOG performance status of ≥ 1. Proof-of-concept clinical data from the Phase 1a first-in-human dose escalation basket trial showed initial anti-tumor activity in multiple tumor types, durable objective responses, including confirmed responses ongoing at 13+ months, a manageable tolerability profile and a half-life of 14+ days. Treatment with IMA401 monotherapy in patients with relevant IMA401 doses and MAGEA4/8high levels (N=17) demonstrated: Objective response rate of 29% with confirmed responses observed in 25% of patients Disease control rate of 53% and tumor shrinkage of 53% As the clinical trial progresses, the Company aims to further leverage the potential of IMA401 by focusing on the enrollment of indications with high MAGEA4/8 target expression, such as lung and head and neck cancer patients, seeking to optimize the treatment schedule and also exploring the incremental clinical benefit available to patients through combining IMA401 with a checkpoint inhibitor. The next data update on IMA401 is expected in 2025. ACTengine® Cell Therapy Programs ACTengine® IMA203 On November 8, 2024, Immatics announced an expanded clinical dataset that included all infused patients in the Phase 1b dose expansion part of the trial (N=41), consisting of the 28 melanoma patients reported on October 10, 2024, and 13 non-melanoma patients, of which 10 non-melanoma patients were reported on November 8, 2023. As of the data cut-off on August 23, 2024, treatment with IMA203 monotherapy in the melanoma patient population has demonstrated: Confirmed objective response rate of 54% and an objective response rate of 62% Disease control rate of 92% and tumor shrinkage in 88% of patients12.1 months median duration of response, 6 months median progression-free survival and >1-year median progression-free survival in patients with deep responsesMedian overall survival has not yet been reached IMA203 monotherapy has maintained a favorable tolerability profile with no treatment-related Grade 5 events in the entire safety population (N=70 Phase 1a and Phase 1b patients across all dose levels and all tumor types). Based on the Phase 1b data and discussions with the U.S. Food and Drug Administration, Immatics is on track to commence SUPRAME, the registration-enabling Phase 3 randomized-controlled clinical trial in melanoma for IMA203, in December 2024. SUPRAME will evaluate IMA203 targeting PRAME in 360 HLA-A*02:01-positive patients with second-line or later (2L+) unresectable or metastatic melanoma who have received prior treatment with a checkpoint inhibitor. Patients will be randomized 1:1 for IMA203 or investigator’s choice of selected approved treatments in the 2L+ setting, including nivolumab/relatlimab, nivolumab, ipilimumab, pembrolizumab, lifileucel (U.S. only) or chemotherapy. The primary endpoint for full approval will be median PFS and secondary endpoints will include objective response rate, safety, duration of response, no overall survival detriment and patient-reported outcomes. Patient enrollment for SUPRAME is forecast to be completed in 2026, and a pre-specified interim analysis is planned for early 2026. Immatics aims to submit a Biologics License Application (BLA) in early 2027 for full approval. ACTengine® IMA203CD8 (GEN2) monotherapy On November 8, 2024, Immatics announced updated Phase 1 dose escalation clinical data on its next-generation ACTengine® IMA203CD8 TCR-T cell therapy in 44 heavily pretreated HLA-A*02:01 and PRAME-positive patients with solid tumors, thereof 41 patients being evaluable for efficacy. Of note, these patients had been treated at substantially lower doses compared to IMA203 (GEN1), i.e. in a range of 0.2-0.48x109 TCR-T cells/m2 BSA (dose level 3) to 0.801-1.2x109 TCR-T cells/m2 BSA (dose level 4c) T cells infused. As of the data cut-off on September 30, 2024, treatment with IMA203CD8 monotherapy demonstrated: Confirmed objective responses observed in 41% of patientsMedian duration of response of 9.2 months at a median follow-up of 13.1 monthsTumor shrinkage of 84% and disease control rate at week 6 of 85%10 out of 17 responses were ongoing, of which three confirmed responses were ongoing at 14+, 15+ and 24+ months Deep responses with ≥50% tumor size reduction were observed in 11 out of 17 responders. This group included two patients with complete response of target lesions, of which one patient showed a complete metabolic response according to PET-CT scan IMA203CD8 monotherapy has maintained a manageable tolerability profile in the 44 patients treated. Based on the enhanced pharmacology of IMA203CD8 demonstrated in this trial, the evaluation of higher doses of IMA203CD8 in the ongoing dose escalation trial opens the possibility of addressing hard-to-treat solid tumor indications with a medium-level of PRAME copy numbers, such as ovarian cancer and endometrial cancer. Corporate Development In September 2024, Immatics regained full clinical development and commercialization rights to IMA401 due to ongoing portfolio prioritization efforts within Bristol Myers Squibb. The Phase 1 dose escalation trial with IMA401 is ongoing and will continue to be conducted by Immatics. Third Quarter 2024 Financial Results Cash Position: Cash and cash equivalents as well as other financial assets total $549.2 million1 (€490.5 million) as of September 30, 2024, compared to $476.8 million1 (€425.9 million) as of December 31, 2023. The increase is mainly due to the public offering in January 2024, partly offset by ongoing research and development activities. Following the $150 million public offering in October 2024, the Company now projects a cash runway into the second half of 2027. Revenue: Total revenue, consisting of revenue from collaboration agreements, was $56.7 million1 (€50.6 million) for the three months ended September 30, 2024, compared to $6.6 million1 (€5.9 million) for the three months ended September 30, 2023. The increase is mainly the result of a one-time revenue associated with the termination of the IMA401 collaboration by Bristol Myers Squibb during the three months ended September 30, 2024. Research and Development Expenses: R&D expenses were $43.6 million1 (€38.9 million) for the three months ended September 30, 2024, compared to $34.1 million1 (€30.5 million) for the three months ended September 30, 2023. The increase mainly resulted from costs associated with the advancement of the clinical pipeline candidates.General and Administrative Expenses: G&A expenses were $12.5 million1 (€11.2 million) for the three months ended September 30, 2024, compared to $10.0 million1 (€8.9 million) for the three months ended September 30, 2023. Net Profit and Loss: Net loss was $9.6 million1 (€8.6 million) for the three months ended September 30, 2024, compared to a net loss of $29.7 million1 (€26.5 million) for the three months ended September 30, 2023. The decrease in net loss results from the increase in recognized revenue in the period. Full financial statements can be found in the 6-K filed with the Securities and Exchange Commission (SEC) on November 18, 2024, and published on the SEC website under www.sec.gov. Upcoming Investor Conferences Jefferies London Healthcare Conference, London, United Kingdom – November 19 – 21, 2024 To see the full list of events and presentations, visit www.investors.immatics.com/events-presentations. About IMA402TCER® IMA402 is a drug candidate owned by Immatics. IMA402 is Immatics’ second TCER® molecule from the bispecifics pipeline and is directed against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma (PRAME), a protein frequently expressed in a large variety of solid cancers, thereby supporting the program’s potential to address a broad cancer patient population. Immatics’ PRAME peptide is present at a high copy number per tumor cell and is homogenously and specifically expressed in tumor tissue. The peptide has been identified and characterized by Immatics’ proprietary mass spectrometry-based target discovery platform, XPRESIDENT®. IMA402 is part of Immatics’ strategy to leverage the full clinical potential of targeting PRAME, one of the most promising targets for TCR-based therapies. - END - About ImmaticsImmatics combines the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the power of T cells and to unlocking new avenues for patients in their fight against cancer. Immatics intends to use its website www.immatics.com as a means of disclosing material non-public information. For regular updates you can also follow us on X, Instagram and LinkedIn. Forward-Looking StatementsCertain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events or the Company’s future financial or operating performance. For example, statements concerning timing of data read-outs for product candidates, the timing, outcome and design of clinical trials, the nature of clinical trials (including whether such clinical trials will be registration-enabling), the timing of IND or CTA filing for pre-clinical stage product candidates, estimated market opportunities of product candidates, the Company’s focus on partnerships to advance its strategy, and other metrics are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “plan”, “target”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in the Company’s Annual Report on Form 20-F and other filings with the Securities and Exchange Commission (SEC). Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. The Company undertakes no duty to update these forward-looking statements. All the scientific and clinical data presented within this press release are – by definition prior to completion of the clinical trial and a clinical study report – preliminary in nature and subject to further quality checks including customary source data verification. For more information, please contact: Media Trophic Communications Phone: +49 171 3512733 immatics@trophic.eu Immatics N.V. Jordan Silverstein Head of Strategy Phone: +1 346 319-3325 InvestorRelations@immatics.com Immatics N.V. and subsidiariesCondensed Consolidated Statement of Loss of Immatics N.V. Three months ended September 30, Nine months ended September 30, 2024 2023 2024 2023 (Euros in thousands, exceptper share data) (Euros in thousands, exceptper share data) Revenue from collaboration agreements 50,559 5,926 99,583 38,076 Research and development expenses (38,906) (30,498) (106,230) (85,396) General and administrative expenses (11,156) (8,881) (32,925) (27,825) Other income 17 186 54 1,134 Operating result 514 (33,267) (39,518) (74,011) Change in fair value of liabilities for warrants 3,833 (1,395) 4,228 (7,103) Other financial income 5,889 9,748 18,707 14,414 Other financial expenses (12,589) (1,575) (5,342) (4,146) Financial result (2,867) 6,778 17,593 3,165 Loss before taxes (2,353) (26,489) (21,925) (70,846) Taxes on income (6,217) — (7,720) — Net loss (8,570) (26,489) (29,645) (70,846) Net loss per share: Basic (0.08) (0.32) (0.29) (0.90) Diluted (0.11) (0.32) (0.31) (0.90) Immatics N.V. and subsidiariesCondensed Consolidated Statement of Comprehensive Loss of Immatics N.V. Three months ended September 30, Nine months ended September 30, 2024 2023 2024 2023 (Euros in thousands) (Euros in thousands) Net loss (8,570) (26,489) (29,645) (70,846) Other comprehensive income Items that may be reclassified subsequently to profit or loss Currency translation differences from foreign operations (1,377) 429 (579) 769 Total comprehensive loss for the year (9,947) (26,060) (30,224) (70,077) Immatics N.V. and subsidiariesCondensed Consolidated Statement of Financial Position of Immatics N.V. As of September 30,2024 December 31,2023 (Euros in thousands) Assets Current assets Cash and cash equivalents 189,199 218,472 Other financial assets 301,321 207,423 Accounts receivables 2,951 4,093 Other current assets 19,306 19,382 Total current assets 512,777 449,370 Non-current assets Property, plant and equipment 48,424 43,747 Intangible assets 1,506 1,523 Right-of-use assets 13,327 13,308 Other non-current assets 1,199 2,017 Total non-current assets 64,456 60,595 Total assets 577,233 509,965 Liabilities and shareholders’ equity Current liabilities Provisions 5,144 — Accounts payables 22,095 25,206 Deferred revenue 68,928 100,401 Liabilities for warrants 14,765 18,993 Lease liabilities 2,825 2,604 Other current liabilities 15,155 9,348 Total current liabilities 128,912 156,552 Non-current liabilities Deferred revenue 52,597 115,527 Lease liabilities 13,198 12,798 Other non-current liabilities — 4 Total non-current liabilities 65,795 128,329 Shareholders’ equity Share capital 1,031 847 Share premium 1,010,648 823,166 Accumulated deficit (626,938) (597,293) Other reserves (2,215) (1,636) Total shareholders’ equity 382,526 225,084 Total liabilities and shareholders’ equity 577,233 509,965 Immatics N.V. and subsidiariesCondensed Consolidated Statement of Cash Flows of Immatics N.V. Nine months ended September 30, 2024 2023 (Euros in thousands) Cash flows from operating activities Net loss (29,645) (70,846) Taxes on income 7,720 — Loss before tax (21,925) (70,846) Adjustments for: Interest income (18,185) (8,993) Depreciation and amortization 9,149 5,432 Interest expenses 654 620 Equity-settled share-based payment 13,112 16,299 Loss from disposal of fixed assets 1 Net foreign exchange differences and expected credit losses 4,018 (760) Change in fair value of liabilities for warrants (4,228) 7,103 Changes in: Decrease in accounts receivables 1,142 596 Decrease/(increase) in other assets (2,623) 658 (Decrease) in deferred revenue, accounts payables and other liabilities (91,113) (15,641) Interest received 11,098 4,904 Interest paid (654) (221) Income tax paid — — Net cash used in operating activities (99,554) (60,849) Cash flows from investing activities Payments for property, plant and equipment (14,598) (21,506) Payments for intangible assets (148) (158) Payments for investments classified in other financial assets (356,596) (299,018) Proceeds from maturity of investments classified in other financial assets 266,361 229,557 Proceeds from disposal of property, plant and equipment 1 — — — Net cash used in investing activities (104,980) (91,125) Cash flows from financing activities Proceeds from issuance of shares to equity holders 174,554 90,404 Transaction costs deducted from equity (2,039) Repayments related to lease liabilities (1,228) (2,877) Net cash provided by financing activities 173,326 85,488 Net decrease in cash and cash equivalents (31,208) (66,486) Cash and cash equivalents at beginning of the year 218,472 148,519 Effects of exchange rate changes, expected credit losses and accrued intereston cash and cash equivalents 1,935 1,413 Cash and cash equivalents at end of the year 189,199 83,446 Immatics N.V. and subsidiariesCondensed Consolidated Statement of Changes in Shareholders’ Equity of Immatics N.V. (Euros in thousands) Sharecapital Sharepremium Accumulateddeficit Otherreserves Totalshare-holders’equity Balance as of January 1, 2023 767 714,177 (500,299) (1,481) 213,164 Other comprehensive income — — — 769 769 Net loss — — (70,846) — (70,846) Comprehensive loss for the year — — (70,846) 769 (70,077) Equity-settled share-based compensation — 16,299 — — 16,299 Share options exercised — 140 — — 140 Issue of share capital – net of transaction costs 80 88,145 — — 88,225 Balance as of September 30, 2023 847 818,761 (571,145) (712) 247,751 Balance as of January 1, 2024 847 823,166 (597,293) (1,636) 225,084 Other comprehensive income — — — (579) (579) Net loss — — (29,645) — (29,645) Comprehensive loss for the year — — (29,645) (579) (30,224) Equity-settled share-based compensation — 13,112 — — 13,112 Share options exercised 1 1,113 — — 1,114 Issue of share capital – net of transaction costs 183 173,257 — — 173,440 Balance as of September 30, 2024 1,031 1,010,648 (626,938) (2,215) 382,526 1 All amounts translated using the exchange rate published by the European Central Bank in effect as of September 30, 2024 (1 EUR = 1.1196 USD). Attachment PDF Version

Phase 1Clinical ResultImmunotherapyFinancial StatementCell Therapy

18 Nov 2024

·www.pharmaceutical-technology.com

EMA’s CHMP to approve BMS’ Opdivo for colorectal cancer

Opdivo and Yervoy combination is used for the first-line treatment of adult patients with colorectal cancer. Credit: Jo Panuwat D/Shutterstock. The European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of a combination therapy consisting of Bristol Myers Squibb ’s (BMS) Opdivo (nivolumab) and Yervoy (ipilimumab) for the first-line treatment of adults with colorectal cancer. The recommendation is specifically for those with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) unresectable or metastatic colorectal cancer (mCRC). The European Commission (EC) will review the CHMP’s recommendation before making a final decision on approval for the European Union (EU). The CHMP’s positive opinion is grounded in the outcomes from the Phase III, open-label CheckMate -8HW trial, which demonstrated a significant 79% decrease in disease progression or mortality risk compared to chemotherapy. The randomised trial evaluated the efficacy of Opdivo in combination with Yervoy against Opdivo alone or the investigator’s choice of chemotherapy. 839 patients were randomised to receive either Opdivo monotherapy, combination therapy or chemotherapy. The combination therapy significantly improved progression-free survival (PFS), meeting the dual primary endpoint compared to chemotherapy, as assessed by blinded independent central review (BICR). The safety profile for the dual immunotherapy combination was in line with previous data without any new safety concerns. The ongoing CheckMate -8HW study will assess secondary endpoints, including overall survival. Further data from October 2024 indicated that the combination therapy also significantly improved PFS compared to Opdivo monotherapy across all lines of therapy. Bristol Myers Squibb gastrointestinal and genitourinary cancers global programme lead and vice-president Dana Walker stated: “Approximately 5 to 7% of metastatic colorectal cancer patients have dMMR or MSI-H tumours, and current treatment options often do not provide sufficient benefit. “This is the first dual checkpoint inhibitor treatment for first-line metastatic colorectal cancer, delivering a transformative benefit for MSI-H/dMMR patients in this population. “We are focused on bringing Opdivo plus Yervoy to these patients in the European Union and look forward to the EC’s upcoming decision.” In the same month, the company received approval from the US Food and Drug Administration for Opdivo to treat adults with resectable non-small cell lung cancer.

Clinical ResultPhase 3ImmunotherapyDrug Approval

15 Nov 2024

·www.globenewswire.com

Arbutus and Barinthus Bio Announce New Data from the IM-PROVE II Trial Showing that the Addition of Nivolumab Increased Rates of HBsAg Loss in People with Chronic Hepatitis B

Significantly greater mean declines in HBsAg levels (p <0.017) were seen in those receiving imdusiran, VTP-300 and low-dose nivolumab compared to other cohorts assessed previously 23% of participants receiving imdusiran, VTP-300 and low-dose nivolumab reached HBsAg loss by Week 48 WARMINSTER, Pa. and OXFORD, United Kingdom, Nov. 15, 2024 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS), (“Arbutus” or the “Company”) a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop a functional cure for people with chronic hepatitis B virus infection, and Barinthus Biotherapeutics plc (NASDAQ: BRNS), a clinical-stage biopharmaceutical company developing novel immunotherapeutic candidates that guide T cells to control disease, today announced new preliminary data from the Phase 2a IM-PROVE II clinical trial (AB-729-202) of people with chronic hepatitis B virus (cHBV) at the American Association for the Study of Liver Diseases (AASLD) – The Liver Meeting® 2024. The new data are from an additional cohort of participants (Group C) who received repeat doses of imdusiran, Arbutus’ RNAi therapeutic, followed by Barinthus Bio's T-cell stimulating immunotherapeutic, VTP-300, with or without low-dose nivolumab, an anti-PD-1 monoclonal antibody. The data indicated that Group C participants receiving nivolumab experienced increased rates of HBsAg loss (defined as HBsAg 0.5 log10 decline in HBsAg between Weeks 26 and 34). This trial was amended to include an additional cohort (Group C) which enrolled 22 participants, 13 of which were eligible to receive imdusiran (60mg every 8 weeks) for 24 weeks with ongoing NUC therapy followed by VTP-300 at Weeks 26 and 30 plus up to two low doses of nivolumab (0.3 mg/kg), an approved PD-1 monoclonal antibody at Week 30. The remaining 9 participants received the imdusiran/NUC/VTP-300 regimen without nivolumab. Participants could receive a second dose of VTP-300 ± low-dose nivolumab at Week 38 if their HBsAg was ≥10 IU/mL at Week 34. Upon completion of the treatment period at Week 48, all participants who met certain criteria could discontinue NUC therapy and be followed for an additional 48 weeks. Those who did not meet the criteria continued on NUC therapy for an additional 24 weeks of follow-up. About Imdusiran (AB-729) Imdusiran is an RNA interference (RNAi) therapeutic specifically designed to reduce all HBV viral proteins and antigens including hepatitis B surface antigen, which is thought to be a key prerequisite to enable reawakening of a patient’s immune system to respond to the virus. Imdusiran targets hepatocytes using Arbutus’ novel covalently conjugated N-Acetylgalactosamine (GalNAc) delivery technology enabling subcutaneous delivery. Clinical data generated thus far has shown single and multiple doses of imdusiran to be generally safe and well-tolerated, while also providing meaningful reductions in hepatitis B surface antigen and hepatitis B DNA. Imdusiran is currently in multiple Phase 2a clinical trials. About VTP-300 VTP-300 is an immunotherapeutic candidate consisting of an initial dose using the ChAdOx vector and a secondary dose(s) using the MVA vector, both encoding multiple HBsAg, including full-length surface, modified polymerase, and core antigens. VTP-300 is the first antigen-specific immunotherapy that has been shown to induce sustained reductions in HBsAg. Barinthus Bio is studying VTP-300 in combination with other agents, including siRNA and low-dose anti-PD-1 antibodies, to control the infection, and counterbalance the immune suppression and T cell exhaustion in the liver caused by chronic HBV infection. About Arbutus Arbutus Biopharma Corporation (Nasdaq: ABUS) is a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics with distinct mechanisms of action, which can potentially be combined to provide a functional cure for patients with chronic hepatitis B virus (cHBV). Arbutus believes the key to success in developing a functional cure involves suppressing HBV DNA, reducing surface antigen, and boosting HBV-specific immune responses. Arbutus’ pipeline of internally developed, proprietary compounds includes an RNAi therapeutic, imdusiran (AB-729), and an oral PD-L1 inhibitor, AB-101. Imdusiran has generated meaningful clinical data demonstrating an impact on both surface antigen reduction and reawakening of the HBV-specific immune response. Imdusiran is currently in two Phase 2a combination clinical trials. AB-101 is currently being evaluated in a Phase 1a/1b clinical trial. For more information, visit www.arbutusbio.com. About Barinthus Bio Barinthus Biotherapeutics (Nasdaq: BRNS) is a clinical-stage biopharmaceutical company developing novel immunotherapeutic candidates designed to guide the immune system to overcome chronic infectious diseases and autoimmunity. Helping people living with serious diseases and their families is the guiding principle at the heart of Barinthus Bio. With a focused pipeline built around its proprietary platform technologies, Barinthus Bio is advancing immunotherapeutic product candidates in infectious diseases and autoimmunity, including: VTP-300, that utilizing its ChAdOx/MVA platform designed as a potential component of a functional cure for chronic HBV infection and VTP-1000, utilizing our SNAP-Tolerance Immunotherapy (SNAP-TI) platform and is designed to treat people with celiac disease. Barinthus Bio is also conducting a Phase 1 clinical trial for VTP-850, a second-generation immunotherapeutic candidate designed to treat recurrent prostate cancer. Barinthus Bio’s differentiated technology platforms and therapeutic approach, coupled with deep scientific expertise and focus on clinical development, uniquely positions the company to navigate towards delivering treatments that improve the lives of people with chronic infectious diseases and autoimmunity. For more information, visit www.barinthusbio.com. Arbutus Forward Looking Statements and Information This press release contains forward-looking statements within the meaning of the Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and forward-looking information within the meaning of Canadian securities laws (collectively, forward-looking statements). Forward-looking statements in this press release include statements about Arbutus’ future development plans for its product candidates; the expected cost, timing and results of its clinical development plans and clinical trials with respect to Arbutus’ product candidates; Arbutus’ expectations with respect to the release of data from its clinical trials and the expected timing thereof; Arbutus’ expectations and goals for its collaborations with third parties and any potential benefits related thereto; and the potential for Arbutus’ product candidates to achieve success in clinical trials. With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of preclinical studies and clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus’ assets; and the stability of economic and market conditions. While Arbutus considers these assumptions to be reasonable, these assumptions are inherently subject to significant business, economic, competitive, market and social uncertainties and contingencies, including uncertainties and contingencies related to patent litigation matters. Additionally, there are known and unknown risk factors which could cause Arbutus’ actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements contained herein. Known risk factors include, among others: anticipated pre-clinical studies and clinical trials may be more costly or take longer to complete than anticipated, and may never be initiated or completed, or may not generate results that warrant future development of the tested product candidate; Arbutus may elect to change its strategy regarding its product candidates and clinical development activities; Arbutus may not receive the necessary regulatory approvals for the clinical development of Arbutus’ products; economic and market conditions may worsen; Arbutus may not realize the anticipated benefits from its recent organizational changes; Arbutus may incur additional unexpected expenses in connection with the organizational changes; Arbutus may experience additional employee turnover as a result of the organizational changes; uncertainties associated with litigation generally and patent litigation specifically; and Arbutus and its collaborators may never realize the expected benefits of the collaborations; and market shifts may require a change in strategic focus. A more complete discussion of the risks and uncertainties facing Arbutus appears in Arbutus’ Annual Report on Form 10-K, Arbutus’ Quarterly Reports on Form 10-Q and Arbutus’ continuous and periodic disclosure filings, which are available at www.sedar.com and at www.sec.gov. All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Arbutus disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law. Barinthus Bio’s Forward Looking Statements This press release contains forward-looking statements regarding Barinthus Bio within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, which can generally be identified as such by use of the words “may,” “will,” “plan,” “forward,” “encouraging,” “believe,” “potential,” “expect,” and similar expressions, although not all forward-looking statements contain these identifying words. These forward-looking statements include, without limitation, express or implied statements regarding our future expectations, plans and prospects, including our product development activities and clinical trials, including timing for readouts of any preliminary, interim or final data or next steps for any of our programs, and our ability to develop and advance our current and future product candidates and programs. Any forward-looking statements in this press release are based on our management’s current expectations and beliefs and are subject to numerous risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks and uncertainties related to the success, cost and timing of our pipeline development activities and planned and ongoing clinical trials, including the risk that the timing for preliminary, interim or final data or initiation of our clinical trials may be delayed, the risk that interim or topline data may not reflect final data or results, our ability to execute on our strategy, regulatory developments, the risk that we may not achieve the anticipated benefits of our pipeline prioritization and corporate restructuring, our ability to fund our operations and access capital, our cash runway, including the risk that our estimate of our cash runway may be incorrect, global economic uncertainty, including disruptions in the banking industry, the conflicts in Ukraine, Israel and Gaza, and other risks identified in our filings with the Securities and Exchange Commission, including our Annual Report on Form 10-K for the year ended December 31, 2023, our Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. We caution you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. We expressly disclaim any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Arbutus Biopharma Contacts: Investor & Media Contact:Lisa M. CaperelliVice President, Investor Relations1-215-206-1822lcaperelli@arbutusbio.com Barinthus Bio Contacts: IR contacts:Christopher M. Calabrese Managing Director LifeSci Advisors+1 917-680-5608ccalabrese@lifesciadvisors.com Kevin GardnerManaging DirectorLifeSci Advisors+1 617-283-2856kgardner@lifesciadvisors.com Media contact:Audra FriisSam Brown, Inc.+1 917-519-9577audrafriis@sambrown.com Company contact:Jonothan BlackbournIR & PR ManagerBarinthus Bioir@barinthusbio.com

Clinical ResultPhase 2ImmunotherapyPhase 1

100 Deals associated with Ipilimumab

External Link

KEGG	Wiki	ATC	Drug Bank
D04603	Ipilimumab	L01XC11	DB06186

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Advanced Renal Cell Carcinoma	EU	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Advanced Renal Cell Carcinoma	IS	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Advanced Renal Cell Carcinoma	LI	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Advanced Renal Cell Carcinoma	NO	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Microsatellite instability-high colorectal cancer	IS	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Microsatellite instability-high colorectal cancer	NO	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Microsatellite instability-high colorectal cancer	LI	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Oesophageal squamous cell carcinoma recurrent	NO	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Oesophageal squamous cell carcinoma recurrent	LI	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Oesophageal squamous cell carcinoma recurrent	IS	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Oesophageal squamous cell carcinoma recurrent	EU	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Unresectable Pleural Malignant Mesothelioma	NO	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Unresectable Pleural Malignant Mesothelioma	EU	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Unresectable Pleural Malignant Mesothelioma	IS	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Unresectable Pleural Malignant Mesothelioma	LI	Bristol-Myers Squibb Pharma EEIG	13 Jul 2011
Esophageal Squamous Cell Carcinoma	AU	Bristol-Myers Squibb Australia Pty Ltd.	04 Jul 2011
Malignant Pleural Mesothelioma	AU	Bristol-Myers Squibb Australia Pty Ltd.	04 Jul 2011
Non-Small Cell Lung Cancer	AU	Bristol-Myers Squibb Australia Pty Ltd.	04 Jul 2011
Renal Cell Carcinoma	AU	Bristol-Myers Squibb Australia Pty Ltd.	04 Jul 2011
Melanoma	US	Bristol Myers Squibb Co.	25 Mar 2011

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Hepatocellular Carcinoma	NDA/BLA	CN	Bristol-Myers Squibb Pharma EEIG	13 Jul 2024
Metastatic melanoma	NDA/BLA	BR	Bristol Myers Squibb Co.	01 Sep 2004
Unresectable Melanoma	NDA/BLA	AR	Bristol Myers Squibb Co.	01 Sep 2004
Unresectable Melanoma	NDA/BLA	BR	Bristol Myers Squibb Co.	01 Sep 2004
Unresectable Melanoma	Phase 3	CA	Bristol Myers Squibb Co.	01 Sep 2004
Unresectable Melanoma	Phase 3	US	Bristol Myers Squibb Co.	01 Sep 2004
Unresectable Melanoma	Phase 3	CH	Bristol Myers Squibb Co.	01 Sep 2004
Unresectable Melanoma	Phase 2	CL	Bristol Myers Squibb Co.	01 Sep 2004
Unresectable Melanoma	Phase 2	ZA	Bristol Myers Squibb Co.	01 Sep 2004

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03575793 (BTCRC-LUN17-127, CTgov)	Phase 1/2	Small cell lung cancer recurrent	39	Ipilimumab+Nivolumab+Plinabulin	slbcydyuvt(jlcdgsrhvb) = grifqjygif wcbcwrcsoj (kslxmnmegm, aeeddcwraj - swrmdgpxce)	-	12 Nov 2024
NCT02046733 (ETOP/IFCT 4-12 STIMULI \| STIMULI, CTgov)	Phase 2	Small Cell Lung Cancer	222	ipilimumab+nivolumab (Observation)	(djaepguxcn) = blwdpgdmyt nwrdsyblcf (lszxepslms, zfgrhepwwd - ybmywfgfta) View more	-	08 Nov 2024
				Ipilimumab+nivolumab (Nivolumab + Ipilimumab)	(djaepguxcn) = zpbwcowwaa nwrdsyblcf (lszxepslms, iijdneglsv - sgjxbttalg) View more
NCT02397720 (CTgov)	Phase 2	Relapsing acute myeloid leukemia \| Treatment related acute myeloid leukaemia \| Chronic Myelomonocytic Leukemia \| Acute Biphenotypic Leukemia \| Refractory acute myeloid leukemia \| Acute bilineal leukemia \| Myelodysplastic Syndromes	150	nivolumab+Azacitidine (Arm 1 A Lead-In (Azacitidine, Nivolumab))	udholaxzmz(anrfmkwiiv) = negswopuhv hfjzjvyiah (yaqkykzurj, bjcmvpqvwu - ngvrnkxvyq) View more	-	04 Nov 2024
				Ipilimumab+nivolumab+Azacitidine (Arm 2 A Lead-In (Azacitidine, Nivolumab, Ipilimumab))	udholaxzmz(anrfmkwiiv) = cpumoiwbgb hfjzjvyiah (yaqkykzurj, kzyvvssvga - gbnhuxnuhv) View more
NCT03215706 (CheckMate 9LA, Pubmed \| Eur J Cancer) Manual	Phase 3	metastatic non-small cell lung cancer First line	719	Nivolumab+ipilimumab +chemotherapy	(ymkfirquxa) = vgkugdkygp fszwqagtyb (ysbnsfcomx ) View more	Positive	01 Nov 2024
				Chemotherapy	(ymkfirquxa) = xqjfcuxols fszwqagtyb (ysbnsfcomx ) View more
NCT03929029 (CTgov)	Phase 1	Melanoma, Cutaneous Malignant	11	Montanide+Ipilimumab+Nivolumab+NeoVax (Nivolumab, NeoVax + Montanide, Ipilimumab (2.5 mg Per Injection Site))	zswhdrfanp(mxiqgfxzun) = hguzpdojgt nyhunfkltl (kktunpbacj, kdhlfrcmsm - qzmcdinrcd) View more	-	31 Oct 2024
				Montanide+Ipilimumab+Nivolumab+NeoVax (Nivolumab, NeoVax + Montanide, Ipilimumab (5.0 mg Per Injection Site))	zswhdrfanp(mxiqgfxzun) = xhweunykix nyhunfkltl (kktunpbacj, yksfmflbag - krukvtyqli) View more
EUCTR2017-002323-25-DK \| NCT03296137 (CTgov)	Phase 1/2	Neoplasms	25	infiltrating lymphocytes+ipilimumab+Fludara+Cyclophosphamide+proleukin (All Participants)	(kghfailafr) = qsxlkpvoeb cgmsqaliep (nxvhpqztrf, tozukhksia - rnlmzmncgy) View more	-	26 Oct 2024
				infiltrating lymphocytes+ipilimumab+Fludara+Cyclophosphamide+proleukin (Treated Participants)	(laqluhyqpg) = tjpecffegq lejwrafdfa (ypnmmjomjy, kmnvwawvbl - lxusumylnv) View more
NCT02833233 (CTgov)	Not Applicable	Early Stage Breast Carcinoma	5	Cryoablation+ipilimumab+Nivolumab	gnbzbkfdoj(hzspalazqy) = oruqepigtt ycncvvuluq (ykstmubcbg, hfcsdfvylg - ixdyzowjkm) View more	-	23 Oct 2024
NCT02879695 (CTgov)	Phase 1	Recurrent B Acute Lymphoblastic Leukemia \| Refractory Mixed Phenotype Acute Leukemia \| Refractory B Acute Lymphoblastic Leukemia \| Recurrent Mixed Phenotype Acute Leukemia	28	Nivolumab+Blinatumomab (Dose Level A1)	pnfpwkgwcq(wnfksknrlq) = muoayyogjx mijglcvbzi (xytikbqdtk, fbaierdyuy - mgvyodjewr) View more	-	16 Oct 2024
				Ipilimumab+Nivolumab+Blinatumomab (Dose Level B1)	pnfpwkgwcq(wnfksknrlq) = ahhjnaqdqs mijglcvbzi (xytikbqdtk, znjdqbgnyy - mpcbxutwqx) View more
NCT00636168 \| NCT02388906 (Pubmed \| J Clin Oncol) Manual	Phase 3	Melanoma Adjuvant	-	Nivolumab (NIVO) (CheckMate 238)	oqsuxphnoy(bimcurykhz) = sqiezunirl kileiqhayy (wqbdmzgwlc, 41.8 - 54.9)	Positive	08 Oct 2024
				Ipilimumab (IPI) (CheckMate 238)	oqsuxphnoy(bimcurykhz) = byyrahcrhr kileiqhayy (wqbdmzgwlc, 32.7 - 44.1)
NCT02027935 (CTgov)	Phase 2	Metastatic melanoma	16	Autologous CD8+ Melanoma Specific T Cells+ipilimumab+Cyclophosphamide+Aldesleukin	azsvkvqntw(othmezoqwy) = uxaddogvxh awjeggafsb (ihkhwnstgt, uvcgomhkjs - kwtplqxabm) View more	-	08 Oct 2024

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