colon cancer liver metastasis

SAN FRANCISCO and SUZHOU, China, Aug. 28, 2024 /PRNewswire/ -- Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, cardiovascular and metabolic, autoimmune, ophthalmology and other major diseases, announces that nearly 20 accepted clinical data of its novel oncology molecules, including six oral presentations, will be released at World Conference on Lung Cancer (WCLC) from Sept 7-10, 2024, in San Diego, U.S., and the European Society of Medical Oncology (ESMO) from Sept 13-17, 2024, in Barcelona, Spain. Key data showcase includes: an oral presentation of updated Phase 1 result of its first-in-class PD-1/IL-2 α -bias (IBI363) in NSCLC (up to 3mg/kg dosage) at WCLC, updated Phase 1 results of IBI363 (PD-1/IL-2 α -bias ) combination therapy in colorectal cancer at ESMO, an oral presentation of updated pivotal Phase 2 results of Dupert® (fulzerasib, KRAS G12C inhibitor) in NSCLC at WCLC, an oral presentation of Phase 1 results of IBI354 (HER2 ADC) in HER2+ solid tumors at ESMO, and multiple clinical results of TYVYT® (sintilimab injection). Dr. Hui Zhou, Senior Vice President of Innovent, stated: "We are very pleased to present a robust set of clinical data for our next-generation innovative bispecific antibodies and ADC molecules across renowned medical conferences of 2024 including ASCO, ESMO Plenary and ESMO GI in June, and WCLC and ESMO in September. We observed the preliminary efficacy and safety signals for those innovative candidates, underscoring their potential for further development and clinical value. As one of the few biopharmaceutical companies with both the technology platforms and robust pipeline in "IO+ADC" areas, Innovent remains dedicated to advancing cancer treatment and is committed to offering doctors and patients more innovative, effective, and safe therapeutic options." Details on the abstracts are listed below: WCLC: Oral Sessions Abstract Title: First-in-Class PD-1/IL-2 Bispecific Antibody IBI363 In Patients with Advanced Non-Small Cell Lung Cancer in a Phase 1 Study Abstract No: MA11.04 Session Type and Title: WCLC 2024-MA11. Building on the Foundations of Current Immunotherapies Presentation Time: Tuesday, September 10, 2024, 13:37-13:42 PDT Presenter: Jianya Zhou,The First Affiliated Hospital of Zhejiang University School of Medicine Abstract Title: KRAS G12C Inhibitor IBI351 In Patients (pts) with Advanced Non-Small Cell Lung Cancer (NSCLC): Updated Results from a Pivotal Phase 2 Study Abstract No: OA14.05 Session Type and Title: WCLC 2024-OA14. New Horizons in Targeting KRAS G12C Presentation Time: Monday, September 9, 2024, 15:52-16:02 PDT Presenter: Qing Zhou, Guangdong People's Hospital Abstract Title: Neoadjuvant Sintilimab plus Chemotherapy in EGFR-mutant NSCLC Followed by adjuvant Osimertinib or Observation: A Phase 2 CTONG2104 Trial Abstract No: MA15.11 Session Type and Title: Mini Oral Presentation Time: Tuesday, September 10, 2024 at 3:48-3:53 PM PDT Presenter: Guangdong Lung Cancer Institute, C. Zhang Abstract Title: First-Line Treatment of Locally Advanced or Metastatic Pulmonary Lymphoepithelioma-like carcinoma: A Multicenter, Single-Arm, Phase 2 Trial Abstract No: MA11.03 Session Type and Title: Mini Oral Presentation Time: Tuesday, September 10, 2024 at 1:32-1:37 PM PDT Presenter: The First Affiliated Hospital of Medical University, C. Zhou ESMO: Oral Sessions Abstract Title: IBI354 (anti-HER2 antibody-drug conjugate [ADC]) in patients (pts) with advanced solid tumors and breast cancer (BC): results from a Phase 1 study Abstract No: 345MO Session Type and Title: ESMO 2024-Mini oral session 1: Breast cancer, metastatic Presentation Time: Sunday, September 15, 2024, 9:15-9:20 AM CEST Presenter: Christina Teng, Scientia Clinical Research, Australia Abstract Title: IBI354 (anti-HER2 antibody-drug conjugate [ADC]) in patients (pts) with advanced gynecological cancers (Gynecol C): results from a phase 1 study Abstract No: 720MO Session Type and Title: ESMO 2024-Mini oral session 2: Gynecological cancers Presentation Time: Sunday, September 15, 2024, 15:45-15:50 CEST Presenter: Jin Shu, Chongqing University Affiliated Cancer Hospital WCLC: Posters Abstract Title: Neoadjuvant Chemoimmunotherapy for Potentially Resectable IIIA/IIIB NSCLC: Survival Updates and Predictive Effect of MRD Abstract No: EP.08D.01 Session Type and Title: E-Poster Presentation Time: Saturday, September 7, 2024 at 11:58-11:59 AM PDT Presenter: First Hospital of Jilin University, K. Ma Abstract Title: Safety and Efficacy of Sintilimab Combined with Anlotinib in Patients with KRAS-Mutant Advanced Non-Small Cell Lung Cancer Abstract No.: P4.11E.10 Session Type and Title: E-Poster Presentation Time: Monday, September 9, 2024 at 6:30 PM PDT Presenter: Peking University Shenzhen Hospital, F. Wang ESMO: Posters Abstract Title: First-in-class PD-1/IL-2 bispecific antibody fusion protein IBI363 + bevacizumab (beva) in patients (pts) with advanced colorectal cancer (CRC): A phase I study Abstract No: 574P Session Type and Title: ESMO 2024-Poster Presentation Time: Monday, September 16, 2024 CEST Presenter: Zhen Yu Lin, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Abstract Title: Safety and efficacy of IBI354 (anti-HER2 ADC) in patients (pts) with advanced gastrointestinal (GI) cancers: results from a Phase 1 study Abstract No: 576P Session Type and Title: ESMO 2024-Poster Presentation Time: Monday, September 16, 2024 CEST Presenter: Jifang Gong, Peking University Cancer Hospital Abstract Title: Hepatic Artery Infusion Chemotherapy (HAIC) Plus Sintilimab and Bevacizumab Biosimilar (IBI305) for Initial Unresectable Hepatocellular Carcinoma (HCC) in Patients with Child-Pugh B Liver Function: A prospective study Abstract No.: 980P Session Type and Title: Hepatocellular carcinoma (HCC) - Poster Presentation Time: Monday, September 16, 2024 Presenter: Tianjin Medical University Cancer Institute & Hospital, Huikai Li Abstract Title: Hepatic arterial infusion chemotherapy combined with Sintilimab and regorafenib as adjuvant therapy for colorectal liver metastasis patients with high risk of recurrent: a single-arm, Phase 2 study Abstract No.: 539P Session Type and Title: Colorectal cancer - Poster Presentation Time: Monday, September 16, 2024 Presenter: Fudan University Shanghai Cancer Center, Lu Wang Abstract Title: Fruquintinib combined with sintilimab and chemotherapy as the first-line treatment in advanced naïve EGFR- and ALK-negative non-squamous non-small cell lung cancer (nsq-NSCLC): Updated results Abstract No: 1329P Session Type and Title: NSCLC, metastatic - Poster Presentation Time: Saturday, September 14, 2024 Presenter: Jiangsu Province Hospital, Pei Ma Abstract Title: Sintilimab plus anlotinib in patients with advanced sarcomas (SINANLOSARC): a single-center, single-arm, Phase 2 trial Abstract No.: 1735P Session Type and Title: Sarcoma - Poster Presentation Time: Saturday, September 14, 2024 Presenter: Shandong Cancer Institute, Shandong Cancer Hospital, Zengjun Liu Abstract Title: Efficacy and safety of sintilimab in combination with anlotinib plus metronomic chemotherapy in advanced triple negative breast cancer (SPACE): preliminary results of a single-arm, multicenter Phase 2 trial Abstract No.: 389P Session Type and Title: Breast cancer, metastatic - Poster Presentation Time: Monday, September 16, 2024 Presenter: Shandong Cancer Institute, Shandong Cancer Hospital, Huihui Li Trial in Progress Abstract Title: Fruquintinib in combination with sintilimab and CAPEOX as first-line treatment for advanced G/GEJ cancer: A phase 1b/2 clinical trial (FUNCTION) Abstract No.: 1475TiP Session Type and Title: Oesophagogastric cancer, Poster Presentation Time: Monday, September 16, 2024 Presenter: Henan Cancer Hospital, Bei-Bei Chen About Innovent Innovent is a leading biopharmaceutical company founded in 2011 with the mission to empower patients worldwide with affordable, high-quality biopharmaceuticals. The company discovers, develops, manufactures and commercializes innovative medicines that treat some of the most intractable diseases. Its pioneering therapies treat cancer, cardiovascular and metabolic, autoimmune and eye diseases. Innovent has 11 products in the market, 3 new drug applications under the NMPA review, 4 assets in Phase III or pivotal clinical trials and 18 more molecules in early clinical stage. Innovent partners with over 30 global healthcare leaders, including Eli Lilly, Roche, Sanofi, Adimab, Incyte and MD Anderson Cancer Center. Guided by the motto, "Start with Integrity, Succeed through Action," Innovent maintains the highest standard of industry practices and works collaboratively to advance the biopharmaceutical industry so that first-rate pharmaceutical drugs can become widely accessible. For more information, visit , or follow Innovent on Facebook and LinkedIn. Forward-looking statement This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words "anticipate", "believe", "estimate", "expect", "intend" and similar expressions, as they relate to Innovent Biologics ("Innovent"), are intended to identify certain of such forward-looking statements. The Company does not intend to update these forward-looking statements regularly. These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of the Company with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond the Company's control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, the Company's competitive environment and political, economic, legal and social conditions. The Company, the Directors and the employees of the Company assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialise or turn out to be incorrect. SOURCE Innovent Biologics

Findings published in open-access journal Genome Medicine. IRVINE, Calif., Jan. 18, 2024 /PRNewswire/ -- Helio Genomics, an AI-driven healthcare company specializing in diagnostics technology and test development for cancer detection, today announced that results from an important new research study have been published in the peer-reviewed journal, Genome Medicine. The study is entitled "Multimodal Epigenetic Sequencing Analysis (MESA) of Cell-free DNA for Non-invasive Colorectal Cancer Detection." This study was conducted as a collaboration between Helio Genomics, its sister company and the Division of Computational Biomedicine at the University of California, Irvine. "We are excited to partner with Helio Genomics in the development of MESA, a groundbreaking innovation in liquid biopsy technology that promises to transform the early detection and management of numerous human diseases," said Dr. Wei Li, the division's Grace B. Bell Endowed Chair and Professor of Bioinformatics. Applied to 690 cell-free DNA (cfDNA) samples from three colorectal cancer clinical cohorts, the novel MESA approach improved cancer detection when compared to traditional approaches that use epigenetic markers of promoter DNA methylation. Key results of the study included: The MESA approach successfully captured both cfDNA methylation features and nucleosome organization information within a single assay. cfDNA methylation data captured in the MESA approach enabled detection of colorectal cancer. Nucleosome organization information (Nucleosome occupancy and fuzziness) captured by the MESA approach also enabled detection of colorectal cancer. Integrating multimodal epigenetic features (cfDNA methylation, nucleosome occupancy, nucleosome fuzziness, and a window protection score as a measure of nucleosome positioning) by using MESA enhanced cancer detection when compared to any single modality alone. MESA was shown to be effective in multiple cohorts of patients, demonstrating the robustness of this multimodal approach. A significant advantage of MESA is its ability to effectively combine four highly complementary epigenetic modalities: cfDNA methylation, nucleosome occupancy, nucleosome fuzziness, and a window protection score (WPS) as a measure of nucleosome positioning across gene promoters and polyadenylation sites. The study found that MESA, by integrating these multiple epigenetic modalities, demonstrated superior accuracy for the detection of colorectal, liver and pancreatic cancers compared to models based on a single modality. As a result, MESA represents a major advancement in non-invasive cancer detection by leveraging comprehensive and complementary epigenetic profiles of cfDNA within a single assay. The underlying discovery that methylation features, nucleosome organization features and fragmentation features can be combined to generate superior models is also the subject of U.S. and international patent applications. "With the combination of Helio's high throughput ECLIPSE platform for data collection and the MESA approach for data analysis, Helio is now in a remarkable position to not only identify many different features of cfDNA that are indicative of disease, but also to develop better models to identify early disease," noted David Taggart, Chief Science Officer for Helio Geonomics. "These two advances will ultimately benefit patients through the development of more accurate, easy to use diagnostic tests that can detect cancers early, when more treatment options are available and curative treatment is more likely." Helio has also developed the HelioLiver test, a multi-analyte blood test designed to aid in the detection of liver cancers. MESA offers a flexible and sensitive approach to capturing and integrating a diverse range of epigenetic features in cell-free DNA (cfDNA) using a single experimental assay. Read the MESA study report here: For information on Helio Genomics and its innovative solutions for early cancer detection, visit . About Helio Genomics Founded in 2016 and headquartered in Irvine, California, Helio Genomics is a cancer diagnostics technology and test developer. The company focuses on creating and advancing cutting-edge AI-enabled technologies to detect and screen for cancer at its earliest stage, including liver and colon cancer. To learn more, please visit . IMAGE DOWNLOAD - IMAGE CAPTION - Helio Genomics logo SOURCE Helio Genomics

Lunit to present two abstracts featuring Lunit SCOPE IO, the company's AI biomarker for immune phenotyping Lunit's presentations this year will highlight the effectiveness of Lunit SCOPE IO as a biomarker to predict treatment outcomes in liver and colon cancer SEOUL, South Korea, Jan. 18, 2023 /PRNewswire/ -- Lunit (KRX:328130.KQ) today announced that it will deliver two poster presentations at the upcoming 2023 ASCO Gastrointestinal Cancers Symposium (ASCO GI), to be held in San Francisco, CA, and online from Jan. 19 – 21. As a leading provider of state-of-the-art cancer diagnostic technology, Lunit has focused on developing novel AI biomarkers for application in immunotherapy. Since 2019, the company has released groundbreaking findings based on its AI-powered tissue analysis platform, Lunit SCOPE, demonstrating the software's predictive value in identifying patients eligible for immunotherapy. This year, Lunit's presentations at ASCO GI 2023 will highlight the effectiveness of Lunit SCOPE IO as a biomarker to predict liver and colon cancer treatment outcomes. Lunit SCOPE IO assesses a patient's cancer tissue slide image by analyzing the distribution of tumor-infiltrating lymphocytes (TILs)—one of the representative immunocytes that fight cancer cells. Based on the spatial distribution of TILs and cancer cells in the tumor microenvironment, Lunit SCOPE IO identifies the sample as one of three immune phenotypes: inflamed, immune-excluded, or immune-desert. One of the studies to be presented investigates the correlation between AI-powered immune phenotype and real-world outcomes in liver cancer. Anti-PD-(L)1 monotherapy or combination with bevacizumab or ipilimumab are approved treatment options for hepatocellular carcinoma (HCC; liver cancer). However, not all patients benefit from immunotherapy regimens, raising a need for biomarkers to predict treatment outcomes. Lunit SCOPE IO was used to assess the correlation between the AI solution's immune phenotype and actual outcomes from two separate immunotherapy regimens across 177 HCC patient cases. Findings showed progression-free survival (PFS) of the nivolumab or nivolumab plus ipilimumab (Niv+/-Ipi) regimen to be significantly longer in patients with high inflamed scores—the proportion of area with a high intra-tumoral TIL infiltration. Thus, results showed that the inflamed score, as evaluated by Lunit SCOPE IO, can be used as a biomarker to predict outcomes of Niv+/-Ipi treatment. Lunit will also present findings from a study assessing the clinical significance of Lunit SCOPE IO for the prediction of prognosis in stage II-III colon cancer patients treated with surgery and adjuvant chemotherapy. Across 289 patients included in the study, TIL quantification evaluated by Lunit SCOPE IO showed clinically meaningful correlations with microsatellite instability status, stage of cancer progression, and the occurrence of perineural invasion—factors known to be associated with the prognosis of colon cancer. Furthermore, patients with low TIL quantification were more likely to exhibit recurrence. "TIL quantification is important in the prediction of prognosis in colon cancer, but assessment usually requires additional tissue processing and interpretational efforts," explained Chan-Young Ock, Chief Medical Officer of Lunit's Oncology Group. "This study shows that AI-powered TIL analysis using only an H&E-stained whole-slide image can provide prognostic information in stage II-III colon cancer patients in a practical manner." "Our presentations at this year's ASCO GI continue to demonstrate the credibility of Lunit SCOPE IO as a practical biomarker as we expand the range of our research across all cancer types," said Brandon Suh, CEO of Lunit. "We will expand our research and commercial access programs for Lunit SCOPE throughout this year to provide optimized treatment to cancer patients around the world." Lunit at ASCO GI 2023: Poster Presentations Company Codes: Korea:328130