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Last update 08 May 2025

Traumatic pancreatitis

Last update 08 May 2025

Basic Info

Synonyms

PANCREATITIS TRAUMATIC, Traumatic pancreatitis, 外傷性膵炎

+ [1]

Introduction-

Drugs associated with Traumatic pancreatitis

Nafamostat Mesilate

Target

Serine protease

Mechanism

Serine protease inhibitors

Active Org.

Nichi-Iko Pharmaceutical Co., Ltd. [+3]

Originator Org.

Nichi-Iko Pharmaceutical Co., Ltd.

Active Indication

Disseminated Intravascular Coagulation [+4]

Inactive Indication

Pancreatitis, Chronic [+1]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date31 Mar 1989

Clinical Trials associated with Traumatic pancreatitis

CTR20160698

/ CompletedPhase 1

注射用甲磺酸萘莫司他人体药代动力学试验

[Translation] Pharmacokinetics of Nafamostat Mesylate for Injection in Human Body

研究健康志愿者单次（10 mg、20 mg、40 mg）和多次（20 mg）给药的药代动力学特征，了解不同剂量甲磺酸萘莫司他在人体内动态变化的规律及其剂量相关性，以及多次连续给药体内蓄积情况，为制定合理临床给药方案提供依据。

[Translation]

The pharmacokinetic characteristics of single (10 mg, 20 mg, 40 mg) and multiple (20 mg) doses of nafamostat mesylate were studied in healthy volunteers to understand the dynamic changes of different doses of nafamostat mesylate in the human body and its dose correlation, as well as the in vivo accumulation of multiple continuous doses, so as to provide a basis for formulating a reasonable clinical dosing regimen.

Start Date14 Sep 2016

Sponsor / Collaborator

Lanzhou Jinglong Medical Technology Co., Ltd.

NCT02487225

/ CompletedPhase 3IIT

Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial

The purpose of this study was to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis.

Start Date01 May 2015

Sponsor / Collaborator

Mayo Clinic

[+1]

100 Clinical Results associated with Traumatic pancreatitis

100 Translational Medicine associated with Traumatic pancreatitis

0 Patents (Medical) associated with Traumatic pancreatitis

232

Literatures (Medical) associated with Traumatic pancreatitis

01 Apr 2025·Stem Cell Reviews and Reports

Stem Cell-Derived Extracellular Vesicles for Acute Pancreatitis: a Systematic Review and Meta-analysis of Preclinical Studies

Review

Author: Huang, Lei ; Wang, Junshi ; Hong, Yinghui ; Ye, Mingliang

BACKGROUNDSeveral studies have reported the effectiveness of stem cell-derived extracellular vesicles (SC-EVs) in disease treatment. However, the efficacy of SC-EVs for severe acute pancreatitis (SAP) remains uncertain. This systematic review aimed to analyze and evaluate the effect of SC-EVs in the treatment of SAP in animal models by summarizing data from published studies.METHODSWe searched Pubmed, Embase, and Web of Science databases to identify preclinical studies investigating the therapeutic effect of SC-EVs on SAP. The primary outcome was the histopathological scores of pancreatic tissues, including inflammation, edema, and necrosis. Other outcome measures included levels of amylase, IL-6, IL-10, and TNF-α. Eligible studies were selected based on the inclusion and exclusion criteria. SYRCLE checklist was adopted to assess the quality and bias risks of included studies. Mean differences and 95% confidence intervals were calculated using the inverse variance method with a random effects model. All statistical analyses were performed using RevMan 5.3 software.RESULTSA total of 8 studies including 126 animals were included. The results of meta-analysis revealed that SC-EVs treatment significantly reduced pancreatic histopathologic scores (total score: MD = -5.17, 95% CI: -5.79, -4.55; inflammation score: MD = -1.44, 95% CI: -1.70, -1.19; edema score: MD = -1.42, 95% CI: -1.75, -1.09; necrosis score: MD = -1.42, 95% CI: -1.80, -1.04), inhibited pro-inflammatory factor release (IL-6: SMD = -3.20, 95% CI: -4.51, -1.88; TNF-α SMD = -5.18, 95% CI: -6.96, -3.40), and enhancing the release of anti-inflammatory factors (IL-10 SMD = 4.15, 95% CI: 2.49, 5.81). Further subgroup analyses displayed SC-EVs treatment obviously attenuated animal pancreatic pathologic injury in traumatic pancreatitis and drug-induced acute pancreatitis, and the effect of SC-EVs to inhibit TNF-α secretion in the drug-induced SAP model was correlated with the dose of SC-EVs injection.CONCLUSIONSThis meta-analysis displayed that SC-EVs were correlated with SAP injury alleviation and pancreas function reservation. Research into the treatment of SAP with SC-EVs is still in its early stage, necessitating further comprehensive investigations in the future to elucidate the therapeutic mechanisms of SC-EVs and their potential application in SAP.

01 Apr 2025·International Journal of Surgery Case Reports

Comments on “duct-related complications of pediatric post-traumatic pancreatitis”: Expanding the discussion

Letter

Author: Alhalabi, Marouf Mouhammad ; Alshiekh, Hussam Aldeen

01 Feb 2025·International Journal of Surgery Case Reports

Duct-related complications of pediatric post-traumatic pancreatitis: A case report from Syria

Article

Author: Kamil, Hazem ; Kheir, Farah Abou ; Ahmad, Loujain ; Moustafa, Leen ; Sandouk, Fayez ; Mahmod, Jaber

INTRODUCTIONPancreatic trauma is a rare type of abdominal injury, representing only 0.3 % of pediatric trauma cases. This condition may progress to chronic pancreatitis and result in multiple complications following damage to the pancreatic duct.PRESENTATION OF CASEA 5-year-old boy presented to the hospital with abdominal pain and had a history of chronic pancreatitis following a bicycle handlebar accident one year ago. Ultrasound screening revealed the presence of abdominal ascites which was treated conservatively. Two months post-treatment, the patient developed a pseudocyst in the head of the pancreas and a right-sided pleural effusion that was treated by inserting a plastic stent into the pancreatic duct through endoscopic retrograde cholangiopancreatography (ERCP). This caused inflammation of the pseudocyst, which was eventually drained to the stomach using endoscopy. No recurrence was observed after removing the stents four weeks later.DISCUSSIONInvasive techniques like ERCP are necessary for some cases of pancreatic fistulas that do not respond well to conservative treatment.CONCLUSIONERCP is an effective way to diagnose and treat several duct-related complications of traumatic pancreatitis. Although ideal management of such rare conditions remains highly debatable, non-invasive strategies are preferable for pediatric patients.

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