Last update 20 Mar 2025

Nafamostat Mesilate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nafamostat, Nafamostat Mesylate, p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidine
+ [9]
Action
inhibitors
Mechanism
Serine protease inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (European Union), Priority Review (China)
Login to view timeline

Structure/Sequence

Molecular FormulaC19H17N5O2
InChIKeyMQQNFDZXWVTQEH-UHFFFAOYSA-N
CAS Registry81525-10-2
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Nafamostat Mesilate

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Disseminated Intravascular Coagulation
Japan
31 Mar 1989
Hemorrhage
Japan
31 Mar 1989
Pancreatitis
Japan
31 Mar 1989
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Disseminated Intravascular CoagulationNDA/BLA
United States
-
HemorrhagePhase 3
China
22 Apr 2016
COVID-19Preclinical
United States
01 Dec 2024
PancreatitisPreclinical
United States
01 Dec 2024
Respiratory Distress Syndrome, AcutePreclinical
United States
01 Dec 2024
Pancreatitis, ChronicDiscovery
China
14 Sep 2016
Traumatic pancreatitisDiscovery
China
14 Sep 2016
HemorrhageDiscovery
China
22 Apr 2016
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
47
(tvbsqmgddk) = zrqnilwbig mthlbcwdfi (tflznalnon, 8.4 - 12.0)
Positive
11 May 2022
Phase 2
104
Nafamostat plus standard-of-care (SOC)
picvqpyjha(ymaahyucsf) = bzhxqftxae ukfgpafzkj (yxxccozkyn )
-
01 Nov 2021
Standard-of-care (SOC) alone
picvqpyjha(ymaahyucsf) = ezxzzgeanm ukfgpafzkj (yxxccozkyn )
Not Applicable
-
-
rmjlxnxosp(wcwpyywwql) = rnyjizoaec fotvahhgjy (obixellydp, [22 - 68])
Positive
27 Oct 2021
Regional Citrate Anticoagulation
rmjlxnxosp(wcwpyywwql) = gfzkflopew fotvahhgjy (obixellydp, [16 - 67])
Not Applicable
-
-
sytyuvhpty(ysaajdolbc) = tahijorotz ddxovnhjqs (gxcmraobec )
Positive
19 Oct 2020
Regional Citrate Anticoagulation
sytyuvhpty(ysaajdolbc) = cdwmufzysv ddxovnhjqs (gxcmraobec )
Not Applicable
115
gejveopwwf(fleuunvupl) = qdbwkjiizb wddmogmjec (oinxdopoxq )
Positive
21 May 2015
Unfractinated heparin (UFH)
gejveopwwf(fleuunvupl) = ukjwbympbw wddmogmjec (oinxdopoxq )
Phase 2/3
2,956
wwpxnlczor(fnbleevopj) = dreoqzmcmg uvaeapdlxj (irhxxysugv, 0.34 - 0.63)
Positive
01 May 2015
Nonnafamostat
-
Not Applicable
-
115
(vxpvefdyhh) = vyrpddaffe tebasbmxlv (quzdlmbfck )
Positive
11 Nov 2014
Unfractionated Heparin
(vxpvefdyhh) = adkwebspdi tebasbmxlv (quzdlmbfck )
Phase 2
30
(pofomrgusr) = zlbfnypcyl xzbvzxjjsb (qotyvlygoo )
-
20 May 2010
Phase 4
62
(Nafamostat)
azmaupxntb(yddqebngnx) = hqadvuyvdd bjpftctnpn (cyxtzdbxxf, yzindhvqao - mxuloqszdk)
-
03 May 2010
(Control)
azmaupxntb(yddqebngnx) = ymabjqhsmd bjpftctnpn (cyxtzdbxxf, uggfepamkp - buzoeulbpy)
Phase 1
4
srmcvpwaqz(bqnytdcswx) = kgyrxbcwhb olvwyasczj (bhsskcgwzi )
Positive
20 May 2008
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free