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Last update 23 Jan 2025

Otomycosis

Last update 23 Jan 2025

Basic Info

Synonyms

Fungal otitis externa, OTOMYCOSIS, Otitis externa fungal

+ [12]

Introduction

Fungus infection of the external ear, usually by ASPERGILLUS species

Drugs associated with Otomycosis

Dexamethasone

Target

Mechanism

GR agonists

Active Org.

Amgen, Inc. [+32]

Originator Org.

Merck & Co., Inc.

Active Indication

Immunoglobulin Light-Chain Amyloidosis [+68]

Inactive Indication

Acute otitis externa [+51]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

United States

First Approval Date30 Oct 1958

SVT-15652

Target-

Mechanism-

Active Org.

Laboratorios Salvat SA

Originator Org.

Laboratorios Salvat SA

Active Indication

Otitis Externa

Inactive Indication

Otomycosis

Drug Highest PhaseNDA/BLA

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

G-238

Target-

Mechanism-

Active Org.-

Originator Org.

Editorial Salvat SL

Active Indication-

Inactive Indication

Otomycosis

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Otomycosis

NCT06530069

/ RecruitingNot ApplicableIIT

Exploring the Risk Factors of Otomycosis: A Case-Control Study

The goal of this observational study is to explore the risk factors of fungal otitis externa in the fungal otitis externa patients The main question it aims to answer is:
What behaviors lead to the occurrence of fungal otitis externa? Participants will complete a detailed questionnaire survey. If there is a comparison group: Researchers will compare the healthy group and the disease group to see if there are any differences.

Start Date01 Aug 2024

Sponsor / Collaborator

Zhongshan Hospital Xiamen University

NCT06431542

/ CompletedPhase 4IIT

Comparison of the Efficacy of Patient Self-Application Versus Physician Application of Triamcinolone Acetonide Econazole Cream in the Treatment of Otomycosis

to analyze the clinical characteristics, types of Fungal Infections, and comparison of the efficacy of patient self-application versus physician application of triamcinolone acetonide econazole cream in otomycosis treatment.

Start Date01 Jun 2024

Sponsor / Collaborator

Zhongshan Hospital Xiamen University

ChiCTR2400084252

/ SuspendedPhase 4IIT

Evaluation of the efficacy of Metobacteriosis (an ear canal spray dressing) in the treatment of fungal otitis externa

Start Date20 May 2024

Sponsor / Collaborator-

100 Clinical Results associated with Otomycosis

100 Translational Medicine associated with Otomycosis

0 Patents (Medical) associated with Otomycosis

445

Literatures (Medical) associated with Otomycosis

01 Mar 2025·Brazilian Journal of Otorhinolaryngology

Otomycosis risk after non-suppurative middle ear surgery

Article

Author: Gul, Fatih ; Ozturk, Ali ; Kocak, Ozgenur ; Ali Babademez, Mehmet

OBJECTIVESThe aim of this study was to investigate the risk factors that may cause postoperative otomycosis in patients undergoing Chronic Nonsuppurative Otitis Media (CNSOM) surgery.METHODSIn this retrospective study, 409 out of 523 patients met the inclusion criteria. 44 patients diagnosed with otomycosis CNSOM were analyzed. Perioperative factors were analyzed to determine the potential risks of otomycosis. The primary factors identified as contributing to otomycosis were firmly adherent cerumen, tympano-meatal flap positioning, and Diabetes Mellitus (DM). The study analyzed the patients' follow-up six months after the surgical procedure. Otomycosis occurring within 30-days of surgery was classified as "early otomycosis", while those occurring later were classified as "late otomycosis".RESULTSGraft success at 6-months showed no significant difference between otomycosis and non-otomycosis groups. We found that the presence of DM, tympano-meatal flap positioning, and firmly adhered cerumen removal were significantly associated with the development of otomycosis. The logistic regression model was significant and explained 9.2% of the variation. Overall, individuals with the presence of advancement flap, DM, and cerumen removal status were respectively 2.0, 2.8, and 2.1 times more likely to have otomycosis. DM was the only risk factor identified in all three patients who developed late otomycosis.CONCLUSIONThis study found that compromised epithelial integrity in the external auditory canal, non-epithelial areas, and reduced blood circulation were independent risk factors for postoperative otomycosis.LEVEL OF EVIDENCE: 4

01 Dec 2024·Medical Mycology Case Reports

Invasive fungal otitis media with peripheral facial paralysis

Article

Author: Gao, Hanbing ; Zhang, Jie ; Guan, Ming ; Kang, Wenjie

Invasive fungal otitis media is clinically rare and diagnosis often delayed. We report a 65-year-old female with Aspergillus fumigatus otitis media complicated by mastoiditis and peripheral facial paralysis. Complete mastoidectomy and type II tympanoplasty, with oral administration of voriconazole for more than 3 months resulted in a successful outcome.

01 Dec 2024·Indian Journal of Otolaryngology and Head & Neck Surgery

Challenges in Management of Uncommon Otologic Fungal Disease – a Case Series and Review of Literature

Article

Author: Mankekar, Gauri ; Peters, Mallory ; Cuevas-Ocampo, Areli ; Mirza, Rusella

The purpose of this study is to describe challenges in diagnosis and treatment of otologic fungal infections.; 2) Methods: Case series and literature review 3) Results: Three patients treated at Louisiana State University Health Sciences Center - Shreveport between November 2020 - November 2023 were identified with complicated fungal otitis externa requiring detailed radiologic and histopathologic workup to aid in diagnosis and management. 4) Conclusion: Diagnosis of otologic fungal infection is often complex due to similar presentation of more common pathogens, overlapping features among common fungal specimens, and limitations of available diagnostic methods. Patient factors, including diabetes with poor glycemic control, may further complicate this challenging disease. High index of clinical suspicion, collaboration between multidisciplinary teams is essential to differentiate between common and uncommon fungal ear infections. A combination of mechanical debridement, topical and/or systemic therapy, and longitudinal follow-up with otolaryngology and infectious disease teams is required for successful treatment.

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