Last update 01 Nov 2024

Intestinal necrosis

Last update 01 Nov 2024

Basic Info

Synonyms

INTESTINAL NECROSIS, Intestinal necrosis, NECROSIS BOWEL

+ [16]

Introduction-

Drugs associated with Intestinal necrosis

ONO-6240

Target

Platelet-activating factor

Mechanism

Platelet-activating factor inhibitors

Active Org.

Shinshu University School of Medicine [+2]

Originator Org.

Ono Pharmaceutical Co., Ltd.

Active Indication

Intestinal necrosis [+1]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SRI 63-119

Target

PAF receptor x Platelet-activating factor

Mechanism

PAF receptor antagonists [+1]

Active Org.

Sandoz Research Institute [+1]

Originator Org.

Sandoz Research Institute

Active Indication

Intestinal necrosis

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SRI 63-072

Target

Platelet-activating factor

Mechanism

Platelet-activating factor inhibitors

Active Org.

Northwestern University [+1]

Originator Org.

Children’s Memorial Hospital of Chicago

Active Indication

Intestinal necrosis

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Intestinal necrosis

100 Translational Medicine associated with Intestinal necrosis

0 Patents (Medical) associated with Intestinal necrosis

Literatures (Medical) associated with Intestinal necrosis

01 Nov 2024·Legal Medicine

Case of a fatal congenital transmesenteric hernia in infancy

Article

Author: Petrović, Tijana ; Banjanin, Irina ; Bogdanović, Milenko ; Radnić, Bojana ; Milošević, Veljko

We present a case of transmesenteric hernia resulting in the death of a 3-month-old female infant, the seventh such autopsy case reported so far. A three-month-old female infant, who initially presented with two episodes of vomiting, cramps, and constipation, was admitted to the hospital. She received symptomatic therapy and was released home. Immediately after she had been put to bed at home, she stopped breathing. There was no record of previous illnesses in the infant's medical history. At autopsy, a necrotic segment of ileum and jejunum, length about 50 cm, was found herniated through an oval defect in the mesentery and multiply strangulated. The shock caused by small intestinal obstruction with consequent intestinal necrosis due to strangulation of the small intestine through a congenital mesenteric defect was considered to be the cause of death. In clinical practice, cases of transmesenteric hernias are uncommon, especially in the population of infants and toddlers; however, these can potentially be the cause of serious intestinal obstruction, with a high mortality rate in cases left untreated. Despite the low incidence of this condition, we believe that the clinicians should keep this diagnosis in mind as a potential cause of acute abdomen and pay special attention to revealing the cause of presented symptoms.

01 Sep 2024·Cureus

Management of Complex Small Bowel Obstructions of Various Etiologies: A Case Series and Literature Review.

Article

Author: Tiesenga, Frederick ; Mayow, Abshiro H ; Edah, Elizabeth ; Singh, Jetvir

A small bowel obstruction (SBO) involves partial or complete blockage of the small intestine. Complete high-grade or closed-loop obstructions constitute acute surgical emergencies necessitating urgent intervention to prevent severe complications. Several probable etiologies of SBO have been identified, including malignancy, stool impaction, and inflammatory bowel disease; however, post-surgical adhesion is the most prevalent cause in the developed world. A SBO can be diagnosed clinically after a physical examination, but imaging is needed for surgical assessment and management. Misdiagnosis and inadequate management of SBO can cause several complications, such as intestinal necrosis and perforation. Therefore, when required, rapid diagnosis and surgical intervention are critical to avoiding mortality. Computer tomography (CT) and small bowel follow-through (SBFT) are widely utilized imaging modalities for confirmatory diagnosis of SBO. This case series features three patients who had exploratory laparotomies following extensive clinical evaluations and a radiologically confirmed diagnosis of SBO. All three cases involved numerous surgeries. The patients presented with severe abdominal discomfort and received surgical intervention after a CT scan confirmed the diagnosis and conservative therapy failed. In this case, all patients had different presentations but responded adequately to the same treatment modalities with no postoperative complications.

01 Jan 2024·Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[An adult case of a small bowel volvulus with intestinal malrotation that resulted in postoperative short bowel syndrome after massive small bowel resection].

Article

Author: Seharada, Kai ; Yokoyama, Takahide ; Nakamura, Kenya ; Shimizu, Fumiaki ; Suzuki, Fumitaka

A 29-year-old man presented to the hospital with complaints of abdominal pain and vomiting. Abdominal computed tomography revealed intestinal malrotation, a whirl sign of the small intestine, and occlusion of the superior mesenteric artery and vein. Due to dilation of the small intestine and poor contrast enhancement of the intestinal wall, he was diagnosed with strangulating small bowel obstruction with intestinal necrosis. Emergency surgery was performed owing to the diagnosis of small bowel volvulus with intestinal malrotation, which necessitated massive small bowel resection. The remnant small intestine was approximately 100cm in length. The patient developed short bowel syndrome postoperatively but eventually resumed a normal diet.

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Intestinal necrosis

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