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Last update 08 May 2025

Intestinal necrosis

Last update 08 May 2025

Basic Info

Synonyms

INTESTINAL NECROSIS, Intestinal necrosis, NECROSIS BOWEL

+ [16]

Introduction-

Drugs associated with Intestinal necrosis

SRI 63-119

Target

PAF receptor x Platelet-activating factor

Mechanism

PAF receptor antagonists [+1]

Active Org.-

Originator Org.

Sandoz Research Institute

Active Indication-

Inactive Indication

Intestinal necrosis

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SRI 63-072

Target

Platelet-activating factor

Mechanism

Platelet-activating factor inhibitors

Active Org.-

Originator Org.

Children’s Memorial Hospital of Chicago

Active Indication-

Inactive Indication

Intestinal necrosis

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

ONO-6240

Target

Platelet-activating factor

Mechanism

Platelet-activating factor inhibitors

Active Org.-

Originator Org.

Ono Pharmaceutical Co., Ltd.

Active Indication-

Inactive Indication

Intestinal necrosis [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Intestinal necrosis

JPRN-UMIN000032228

/ SuspendedNot ApplicableIIT

Investigation for the mechanism of bacterial translocation in patients undergoing surgery of intestinal necrosis. A multiple institutional prospective study. - Investigation for the mechanism of bacterial translocation in patients undergoing surgery of intestinal necrosis.

Start Date01 Oct 2018

Sponsor / Collaborator-

100 Clinical Results associated with Intestinal necrosis

100 Translational Medicine associated with Intestinal necrosis

0 Patents (Medical) associated with Intestinal necrosis

2,076

Literatures (Medical) associated with Intestinal necrosis

01 Jun 2025·International Journal of Surgery Case Reports

Uterine perforation and bowel incarceration following a second trimester abortion

Article

Author: Atri, Souhaib ; Mahmoud, Ahmed Ben ; Haddad, Anis ; Sebai, Amine ; Kacem, Montassar ; Zaiem, Aida

INTRODUCTIONUterine perforation is a rare but potentially life-threatening complication of elective abortion, often occurring without immediate symptoms.CASE REPORTThis case report describes a 32-year-old woman who developed small bowel incarceration within the uterine cavity following a second-trimester abortion. She presented five days post-procedure with acute abdominal pain, nausea, and vomiting. Physical and laboratory examinations indicated elevated white blood cell count and Creactive protein levels, while imaging studies, including CT scans, revealed a dilated small bowel loop incarcerated within the uterus. Surgical intervention was performed, identifying a uterine defect and an incarcerated small intestine, which was well vascularized. After reducing the bowel and repairing the uterine perforation, the patient made a full recovery.DISCUSSIONUterine perforation during abortion has a reported incidence of 0.05 % to 1.9 %, with second-trimester procedures associated with higher complication rates. This case underscores the importance of recognizing such rare complications, as symptoms like pain, vomiting, and fever can delay diagnosis. Differential diagnoses include retained products of conception, pelvic inflammatory disease, and nongynecological causes of abdominal pain. Imaging, particularly CT scans, is essential for diagnosing uterine perforation and bowel incarceration. Treatment typically involves timely surgical intervention to prevent further complications such as bowel necrosis, infection, or death. Strategies to reduce the risk of uterine perforation include careful preoperative evaluation, slow cervical dilation, and meticulous surgical technique.CONCLUSIONThis report highlights the significance of early diagnosis and intervention to reduce morbidity and mortality associated with uterine perforation following abortion.

01 Jun 2025·Photoacoustics

Photoacoustic oxygenation imaging to identify ischemia/hypoxia injury and necrosis of intestine after acute intussusception: A comparative study with CDFI/CEUS

Article

Author: Gou, Zehui ; Luo, Yan ; Ling, Wenwu ; Wang, Hong ; Zhu, Xiaoxia ; Yan, Hualin ; Liu, Juxian ; Huang, Lin

Acute intussusception is a pediatric abdominal emergency that requires immediate diagnosis and treatment. However, accurately identifying bowel necrosis non-invasively remains challenging with conventional sonography. In our study, we investigated the potential of photoacoustic imaging (PAI) as an innovative method for assessing ischemia/hypoxia injury and intestinal necrosis in cases of acute intussusception. Using PAI, we measured intestinal oxygen saturation (sO₂) levels and total hemoglobin (HbT) in various models of acute intussusception at different time points. Additionally, we evaluated blood supply and ischemia/hypoxia injury using color Doppler flow imaging (CDFI) and contrast-enhanced ultrasound (CEUS). Based on histopathological results, intestinal sO₂ measured by PAI demonstrated optimal diagnostic performance for both ischemia/hypoxia injury and intestinal necrosis, with AUC values of 0.997 and 0.982, respectively, while CDFI and CEUS showed relatively high diagnostic performance for both ischemia/hypoxia injury and intestinal necrosis. In conclusion, PAI represents a promising, non-invasive imaging modality for assessing acute intussusception.

01 May 2025·Annals of Vascular Surgery

Nonocclusive Mesenteric Ischemia in Aortic Surgery: What You Need to Know

Review

Author: Refaie, Mohamed ; Jubouri, Matti ; Murtada, Ali ; Mohammed, Idhrees

BACKGROUNDNonocclusive mesenteric ischemia (NOMI), a subtype of acute mesenteric ischemia (AMI), is primarily caused by mesenteric arterial vasoconstriction and decreased vascular resistance, leading to impaired intestinal perfusion.Commonly observed after cardiac surgery, NOMI affects older patients with cardiovascular or systemic diseases, accounting for 20-30% of AMI cases with a mortality rate of ∼50%. This review explores NOMI's pathophysiology, clinical implications in aortic dissection, and the unmet needs in diagnosis and management, emphasizing its prognostic significance.METHODSA comprehensive literature review was conducted using multiple electronic databases to extract relevant data and information.RESULTSNOMI is a life-threatening condition characterized by mesenteric vasoconstriction and reduced splanchnic blood flow, often triggered by cardiac surgery, hemodialysis, or hypotensive episodes. Epidemiological studies highlight its prevalence in intensive care unit settings, with a high mortality rate linked to delayed diagnosis and systemic hypoperfusion. Risk factors include advanced age, vasopressor use, and inflammatory markers. Biomarkers such as intestinal fatty acid binding protein, citrulline, and D-lactate show potential for early detection but lack robust clinical validation. Management includes fluid resuscitation, vasodilators, and surgical intervention for bowel necrosis. Emerging endovascular approaches show promise but are limited to select cases without bowel infarction. This review underscores the critical need for timely diagnosis, risk factor identification, and tailored interventions to improve outcomes.CONCLUSIONNOMI remains poorly understood despite advances in surgical and perioperative care. Its pathophysiology, linked to cardiopulmonary bypass and intraoperative factors, requires heightened clinical vigilance. Limited evidence underscores the need for a multidisciplinary approach involving surgeons, radiologists, and anesthetists to improve diagnosis, management, and outcomes in aortic surgery patients.

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Intestinal necrosis

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