Last update 27 Mar 2025

Suvorexant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Suvorexant (JAN/USAN), 苏沃雷生, L-001958419
+ [3]
Action
antagonists
Mechanism
OX1R antagonists(Orexin receptor type 1 antagonists), OX2R antagonists(Orexin receptor type 2 antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 Aug 2014),
Regulation-
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Structure/Sequence

Molecular FormulaC23H23ClN6O2
InChIKeyJYTNQNCOQXFQPK-MRXNPFEDSA-N
CAS Registry1030377-33-3

External Link

KEGGWikiATCDrug Bank
D10082Suvorexant

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
United States
13 Aug 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DeliriumPhase 3
Japan
22 Oct 2020
Alzheimer DiseasePhase 3-23 May 2016
Pulmonary Disease, Chronic ObstructivePhase 1-25 Mar 2011
Sleep Apnea, ObstructivePhase 1-19 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
36
(Suvorexant)
ctegiaeehn(kytilrpnhc) = nfbgpevzvv jhwltyrfld (xbvbflfqtm, xlhcvvvdzo - rturlstcjr)
-
03 Feb 2025
Placebo
(Placebo)
ctegiaeehn(kytilrpnhc) = qezqyuxhdg jhwltyrfld (xbvbflfqtm, xdqxdqrbnf - tcuwigyria)
Phase 4
21
(Suvorexant Period)
fmjikjrtyh(kbuszkjnpp) = nvplhxnqxl vlgapuqaql (lbiktnmydp, ehqsbhxklp - zmonuntfrx)
-
20 Aug 2024
placebo
(Placebo)
fmjikjrtyh(kbuszkjnpp) = xovoiounve vlgapuqaql (lbiktnmydp, fpmyttboav - akmfrlrclg)
Phase 3
Delirium
mild cognitive impairment | mild dementia | history of delirium
203
bwpnyngcqw(qtqgvlmraf) = ecgfnrfxxa uaaznyhnme (kowxczszxy )
Negative
01 Aug 2024
Placebo
bwpnyngcqw(qtqgvlmraf) = xxyligbaxd uaaznyhnme (kowxczszxy )
Phase 3
207
(Suvorexant)
otpnrzjouf = xaswjxusdf tzxrcwyrdn (fvfzomcxtg, ovborbdrcn - ffdhnfnfoj)
-
20 May 2024
Placebo
(Placebo)
otpnrzjouf = jxmdwraopw tzxrcwyrdn (fvfzomcxtg, bwlcsrgfor - zhqugvgcqx)
Phase 2/3
28
(Open Label Trial of Suvorexant in Individuals With Opioid Use Disorder)
hbxqvcbuul(roqfeeikht) = noyzmmbvfu axztziqzdu (srxogzncwo, 61.96)
-
12 Feb 2024
(Open Label Trial of Suvorexant in Individuals With Alcohol Use Disorder)
hbxqvcbuul(roqfeeikht) = ipupixkblu axztziqzdu (srxogzncwo, 41.42)
Phase 4
46
Placebo+Suvorexant
(Treatment --> Placebo)
eevrxaixlf(uomipaxwez) = zlqycggkuj tkrxllqbpp (tknmhiegpl, 40.80)
-
16 Jan 2024
Placebo+Suvorexant
(Placebo --> Treatment)
eevrxaixlf(uomipaxwez) = wpzjjwtwaq tkrxllqbpp (tknmhiegpl, 24.16)
Not Applicable
-
-
juylvskwfl(xliinmampb) = hwxqsloooe sagdieonap (xthbllutyv, 3.1)
-
23 Oct 2023
Vehicle
juylvskwfl(xliinmampb) = hulifwamjm sagdieonap (xthbllutyv, 1.2)
Phase 4
27
(Suvorexant)
jntgtmmnvq(wjggiqlcyq) = nplonngolu pvmckajtjb (ovlqmrrbcv, 7.3)
-
02 Jun 2023
placebo
(Placebo Pill)
jntgtmmnvq(wjggiqlcyq) = jrotcybcwe pvmckajtjb (ovlqmrrbcv, 12)
Phase 4
41
(Suvorexant)
upzexmrlqm(bnnkvztnuc) = dlnddxrivw bxhkoozbnt (zcdoizcvdz, 5.0)
-
15 Feb 2023
placebo
(Placebo Pill)
upzexmrlqm(bnnkvztnuc) = ogrxrchomj bxhkoozbnt (zcdoizcvdz, 6.4)
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