Delving into the Latest Updates on Morus Leaf Extract with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

Morus indica L. Leaf Extract, Mulberry Leaf Extract

Target-

Mechanism-

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication-

Inactive Indication

Diabetes Mellitus, Type 2

Originator Organization

University of Mississippi Medical Center

Active Organization-

Inactive Organization

University of Mississippi Medical Center

Drug Highest PhasePendingPhase 2/3

First Approval Date-

Regulation-

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Volunteers will be divided into 4 groups which are mulberry leaf extract 6 mg capsule, mulberry leaf extract 12 mg capsule, mulberry leaf extract 18 mg capsule, and placebo capsule group. They will be tested blood glucose levels (taken from the fingertips) before starting. Then, they will take 1 capsule of the sample one time. After taking the sample for 30 minutes, they will take 50 g of sucrose in 250 ml of water in 5 minutes. Then, they will be tested blood glucose levels (taken from the fingertips) at 30, 60, 90, and 120 minutes.

Start Date01 Jul 2024

Sponsor / Collaborator

University of Chulalongkorn

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100 Clinical Results associated with Morus Leaf Extract

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100 Translational Medicine associated with Morus Leaf Extract

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100 Patents (Medical) associated with Morus Leaf Extract

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20

Literatures (Medical) associated with Morus Leaf Extract

15 Jan 2024·Cureus

A Systematic Review of the Efficacy and Safety of Mulberry Formulations for Chemotherapy- and/or Radiotherapy-Induced Oral Mucositis

Review

Author: Shabana, Shaik ; Tanvi, Khandekar ; Asha, V ; Sowbhagya Lakshmi, A ; Raghunand Sindhe, J ; Arvind, Muthukrishnan ; Ananta, Gimre

Oral mucositis (OM) is one of the common side effects of radiotherapy and chemotherapy. It is an extremely painful condition characterized by erythema, edema, and ulceration of the oral mucosa. Many plant-based and chemical formulations are used to prevent OM. The aim of the study is to evaluate the efficacy and safety of different black mulberry formulations in chemotherapy and/or radiotherapy-induced OM. A systematic search was performed using PubMed, Excerpta Medica database (Embase), the Cochrane Library, and Web of Science databases for articles published until March 2023. We have included studies conducted on people undergoing chemotherapy and/or radiotherapy and compared the effect of any mulberry formulation with other interventions. Out of 30 articles retrieved, four articles with a cumulative sample size of (N = 297) were included in the review. Mulberry formulations were compared with no intervention, grape molasses, chlorhexidine, and sodium bicarbonate. Out of the four articles, in three articles, mulberry formulations showed a significant decrease in grade 2 and grade 3 OM and also showed better prevention of OM as compared to the other intervention and control groups, and in one article, the grape molasses was more preventive for the occurrence of OM. Mulberry showed a significant decrease in dry mouth. Mulberry showed more improvement in the pain score and quality of life. The incidence and severity were lower in the mulberry group than in other interventions. One article showed less weight loss, and another article showed gradual weight gain from the use of mulberries. From this, we conclude that mulberry is effective for the treatment of OM. Mulberry also shows improvement in the pain score and quality of life.

01 Dec 2022·Journal of Clinical Pharmacy and Therapeutics

Impact of mulberry consumption on cardiometabolic risk factors: A systematic review and meta‐analysis of randomized‐controlled trials

Review

Author: Chen, Xibin ; Nateghi, Mahsa ; Sohouli, Mohammad Hassan ; Melekoglu, Ebru ; Fatahi, Somaye

OBJECTIVEThe current study aimed to comprehensively evaluate the potential effects of mulberry consumption on cardiometabolic risk factors in adults.METHODSRelevant articles published up to January 2021 were systematically retrieved from SCOPUS, PubMed/MEDLINE, EMBASE, and Web of Science databases. We included all randomized controlled trials (RCTs) investigating the impact of mulberry consumption on various cardiometabolic risk factors.RESULTSThe quantitative meta-analysis of 12 eligible RCTs demonstrated a significant reducing effect of mulberry consumption on haemoglobin A1c (HbA1c) (weighted mean difference [WMD]: -0. 55, 95% CI: -1.08, -0.02, p = 0.044), serum total cholesterol (TC) (WMD: -13.13 mg/dl, 95% CI: -19.06, -7.20, p < 0.001), low-density lipoprotein levels (LDL-C) (WMD: -8.84 mg/dl, 95% CI: -13.26, -4.42, p < 0.001), triglycerides (TG) (WMD: -19.67 mg/dl, 95% CI: -30.13, -9.22, p < 0.001) and C-reactive protein (CRP) (WMD: -1.60, mg/L, 95% CI: -3.07, -0.12, p = 0.034). Also, >300 mg daily intake of mulberry exhibited a favourable effect on serum high-density lipoprotein levels (HDL-C). However, there were no significant differences between mulberry intervention and control groups for other factors.CONCLUSIONThe current systematic review and meta-analysis revealed that incorporating mulberry into the diet may favourably affect several cardiometabolic risk factors.

01 Apr 2021·Poultry Science

Mulberry leaf polysaccharide supplementation contributes to enhancing the respiratory mucosal barrier immune response in Newcastle disease virus–vaccinated chicks

Author: Wang, Jing ; Yang, Haifeng ; Jia, Jiping ; Chen, Yu ; Jiang, Chunmao ; Chen, Haifeng ; Chen, Xiaolan

100 Deals associated with Morus Leaf Extract

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetes Mellitus, Type 2	Phase 3	US	University of Mississippi Medical Center	01 Apr 2008

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00795704 (Mul-DM, CTgov)	Phase 2/3	Diabetes Mellitus, Type 2	24	Placebo (Placebo)	(cqnfsobrns) = qoxdmwcobb ligkfnsuki (qbzxvlfttu, ywhbrcldht - xrksthwmps) View more	-	09 Aug 2012
				Mulberry Leaf Extract (Mulberry Leaf Extract)	(cqnfsobrns) = btqzeubwtr ligkfnsuki (qbzxvlfttu, eielkrusxu - teudtcooys) View more