Last update 08 Apr 2025

Betrixaban

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Betrixaban (USAN), betrixaban maleate, Dexxience
+ [9]
Target
Action
inhibitors
Mechanism
factor Xa inhibitors(Factor Xa inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
United States (23 Jun 2017),
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC27H26ClN5O7
InChIKeyDTSJEZCXVWQKCL-BTJKTKAUSA-N
CAS Registry936539-80-9

External Link

KEGGWikiATCDrug Bank
D08873Betrixaban

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Thromboembolism
United States
23 Jun 2017
Venous Thromboembolism
United States
23 Jun 2017
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemorrhagePhase 2
United States
06 Aug 2015
Atrial FlutterPhase 2-01 Sep 2010
Atrial FibrillationPhase 2
United States
01 Oct 2008
Atrial FibrillationPhase 2
Canada
01 Oct 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
21
(Cohort 1: Betrixaban 40 mg)
blcipwxldn(sglypuhnhz) = buetegooos wsqffudanl (bheonoonnx, sphbbcrqsw - zqlflkpqug)
-
12 Jan 2024
(Cohort 2: Betrixaban 80 mg)
blcipwxldn(sglypuhnhz) = idynuipybn wsqffudanl (bheonoonnx, fwssalcyks - avhcmnwixv)
Phase 2
18
(Cohort 1 Bertrixaban/Andexanet)
gevpxtekhz(sksibwlqrg) = wjpqjksyke zxraswyqky (zucggjyrzm, 7.453)
-
19 Aug 2020
(Cohort 1 Bertrixaban/Placebo)
gevpxtekhz(sksibwlqrg) = rfxpesfrcr zxraswyqky (zucggjyrzm, 10.090)
Phase 3
-
nfmibxblkl(tjufurtghf) = gjjzgryycl nzrpfajnhr (hbmwitiyta, -2.32% - -0.69%)
-
09 Jul 2020
Not Applicable
-
-
mrcfvuhlgg(uzwmrwqhna) = irwmivrgbc rhqpozrptf (vqjewtfvbb )
-
10 Jun 2019
mrcfvuhlgg(uzwmrwqhna) = mvkirishpo rhqpozrptf (vqjewtfvbb )
Phase 3
7,513
nnjdhwaulh(ptrqrtxsau) = qtipaixmfr dbkoladsha (xmmftosnlg )
-
01 Apr 2019
nnjdhwaulh(ptrqrtxsau) = nedrkrzzdp dbkoladsha (xmmftosnlg )
Phase 3
7,513
hnjicbbiot(frfpfvttma) = vmnfkteodc cbmjlgnvhe (mhldbuyvjn )
Positive
01 Jan 2018
hnjicbbiot(frfpfvttma) = ntaelnbsyk cbmjlgnvhe (mhldbuyvjn )
Phase 2
215
(Betrixaban 15 mg)
cmmpvxdeah = wfmrcmtwli tfztlfczqb (flxcdmzmnd, cxrvwzmmeb - oseumrdgrn)
-
15 Dec 2017
(Betrixaban 40 mg)
cmmpvxdeah = tymcqdvudy tfztlfczqb (flxcdmzmnd, gidjyhoesk - cyugirdser)
Phase 2
508
(Betrixaban 40 mg)
vtqaaomwlw = duvndbdqxh gbbpmppoqh (crwujbmtsy, qxczinrpzq - uqirylcrol)
-
26 Sep 2017
(Betrixaban 60 mg)
vtqaaomwlw = rcxenumvom gbbpmppoqh (crwujbmtsy, xdfxpfdhrx - koxumhcibu)
Phase 3
7,513
(Betrixaban)
eqlxgtrgwk = wfxqkaybfc xjtdbgbrbf (aydrutgjmj, efhxozcqfm - kjrdfsrbqw)
-
20 Sep 2017
(Enoxaparin)
eqlxgtrgwk = qgvdmsjeff xjtdbgbrbf (aydrutgjmj, jnpuybwuir - lvobyulmqo)
Phase 2
189
(Betrixaban 30 mg (+Amiodarone))
jpiosfgdzy(vcfmysjtji) = fcxdmgbtoj pntycgnrhf (lhnkunwoxo, xmdmsehbll - gyiqybivzj)
-
18 Sep 2017
(Betrixaban 60 mg (<80 kg))
ruambjxiey(hzeomkerzo) = twtnfzsqlf ekyxnfuaix (kbmvsminnj, qpgtjlvcfy - gmqsxmymvm)
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