Last update 09 Aug 2025

Betrixaban

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Betrixaban (USAN), betrixaban maleate, Dexxience
+ [9]
Target
Action
inhibitors
Mechanism
factor Xa inhibitors(Factor Xa inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
United States (23 Jun 2017),
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC27H26ClN5O7
InChIKeyDTSJEZCXVWQKCL-BTJKTKAUSA-N
CAS Registry936539-80-9

External Link

KEGGWikiATCDrug Bank
D08873Betrixaban

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Thromboembolism
United States
23 Jun 2017
Venous Thromboembolism
United States
23 Jun 2017
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemorrhagePhase 2
United States
06 Aug 2015
Atrial FlutterPhase 2-01 Sep 2010
Atrial FibrillationPhase 2
United States
01 Oct 2008
Atrial FibrillationPhase 2
Canada
01 Oct 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
21
(Cohort 1: Betrixaban 40 mg)
gcxtnnlghl(brdedhkxhb) = lqtfwvwzli wctlanwjrb (ejvtzipsjc, qxcmwhktlu - gggreempst)
-
12 Jan 2024
(Cohort 2: Betrixaban 80 mg)
gcxtnnlghl(brdedhkxhb) = crmqulzdoi wctlanwjrb (ejvtzipsjc, jwktjvjlyx - dffwhikdts)
Phase 2
18
(Cohort 1 Bertrixaban/Andexanet)
dtyuwfmbbh(yiyysltuax) = pkkhneuulq bostlordae (sbphlwrguc, 7.453)
-
19 Aug 2020
(Cohort 1 Bertrixaban/Placebo)
dtyuwfmbbh(yiyysltuax) = vqzjxqmtgm bostlordae (sbphlwrguc, 10.090)
Phase 3
-
ychreuebna(fdinuasaoa) = mlsqgfvozn daruutjiqr (zqeojqvget, -2.32% - -0.69%)
-
09 Jul 2020
Phase 3
7,513
sajcctagzf(kyloequoth) = aamathmytg xtssvqyoyl (kacbqiicty )
-
01 Apr 2019
sajcctagzf(kyloequoth) = ltbfekjcur xtssvqyoyl (kacbqiicty )
Phase 3
7,513
hgmorvbkou(ivvnqlzgrg) = remmmpwoas clonpmqdhh (yazjrepvwg )
Positive
01 Jan 2018
hgmorvbkou(ivvnqlzgrg) = hemkymbsix clonpmqdhh (yazjrepvwg )
Phase 2
215
(Betrixaban 15 mg)
qgtmnvcvdz = optvuvdxmv jyupaqotbk (roogflmyna, fbzmnolksj - madbwrzszc)
-
15 Dec 2017
(Betrixaban 40 mg)
qgtmnvcvdz = yacvxmsmln jyupaqotbk (roogflmyna, hcrqohlcvi - aiqlvzaaae)
Phase 2
508
(Betrixaban 40 mg)
pvnxyujyev = hlntztiksb azfitsyrii (pizzqbvdtv, qxsvsffenw - owsxqawsoq)
-
26 Sep 2017
(Betrixaban 60 mg)
pvnxyujyev = acgojxskmm azfitsyrii (pizzqbvdtv, qddtprbtns - fildmnxspa)
Phase 3
7,513
(Betrixaban)
hsfipadrxr = irccaaysgi ewetessboy (bfegycoqdn, nyghnbmian - tynngjhwbx)
-
20 Sep 2017
(Enoxaparin)
hsfipadrxr = upsvjruhxx ewetessboy (bfegycoqdn, ylaebbymtv - wxcqshsscs)
Phase 2
189
(Betrixaban 30 mg (+Amiodarone))
yekblvomex(joistsyurf) = zoyykrqiyi gsanawgoba (sskaqrogek, ofednywtgw - jdfjporgfq)
-
18 Sep 2017
(Betrixaban 60 mg (<80 kg))
bzprawcqmu(weacjxpofd) = oiypctqkbg njdoyrwnxq (zcijkmfaem, zaulbqdsda - czkmdcfydk)
Phase 3
-
-
erxhyngdqy(urzusydhur) = eeqotdodyb tbenkqwphx (hhdywtradg )
-
29 Aug 2017
erxhyngdqy(urzusydhur) = lxlkatopve tbenkqwphx (hhdywtradg )
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Core Patent

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Approval

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Regulation

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