Drug Type Small molecule drug |
Synonyms 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid, 5-(2,4-difluorophenyl)salicylic acid + [7] |
Target |
Action inhibitors |
Mechanism COX inhibitors(Cyclooxygenases inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (19 Apr 1982), |
RegulationOrphan Drug (European Union) |
Molecular FormulaC13H8F2O3 |
InChIKeyHUPFGZXOMWLGNK-UHFFFAOYSA-N |
CAS Registry22494-42-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00130 | Diflunisal |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Osteoarthritis | United States | 19 Apr 1982 | |
Pain | United States | 19 Apr 1982 | |
Rheumatoid Arthritis | United States | 19 Apr 1982 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Amyloidosis, Hereditary, Transthyretin-Related | NDA/BLA | European Union | 25 Apr 2025 |
Phase 2/3 | 130 | (Diflunisal) | sgzxlscclx(cgtfxjteub) = jedypobqxd bbjzggeqzn (liuxctuzos, fbzjgrtvhv - ffzyhvcwdu) View more | - | 17 Mar 2017 | ||
placebo (Placebo) | sgzxlscclx(cgtfxjteub) = wibnxesedu bbjzggeqzn (liuxctuzos, tgztepofov - vyiuyjzxyz) View more | ||||||
Phase 2/3 | 130 | uhaopfptzj(lazdvqeobq) = gernlajvdn dtmflkyreu (zysdgkisnz, 3.3 - 14.1) View more | Positive | 25 Dec 2013 | |||
Placebo | uhaopfptzj(lazdvqeobq) = nimzeefuph dtmflkyreu (zysdgkisnz, 18.4 - 31.6) View more | ||||||
Not Applicable | Amyloid Neuropathies, Familial ATTR Val30Met FAP | 18 | kqisuchasf(tzdrfauwhs) = deterioration of renal function resulted in discontinuation of the study drug in two patients fowdyirabz (ufqrhqedfu ) View more | Positive | 12 Feb 2013 | ||