Last update 24 Dec 2024

Vericiguat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
维利西呱, BAY 102, BAY 1021189
+ [8]
Target
Mechanism
sGC stimulants(Soluble guanylate cyclase stimulants)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Jan 2021),
RegulationFast Track (US), Priority Review (CN), Conditional marketing approval (CN), Special Review Project (CN)
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Structure

Molecular FormulaC19H16F2N8O2
InChIKeyQZFHIXARHDBPBY-UHFFFAOYSA-N
CAS Registry1350653-20-1

External Link

KEGGWikiATCDrug Bank
D11051Vericiguat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Reduced ejection fraction co-occurrent and due to chronic heart failure
CN
18 May 2022
Chronic heart failure
EU
16 Jul 2021
Chronic heart failure
IS
16 Jul 2021
Chronic heart failure
LI
16 Jul 2021
Chronic heart failure
NO
16 Jul 2021
Heart Failure
US
19 Jan 2021
Shock
US
19 Jan 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Left ventricular systolic dysfunctionPhase 3
BE
31 May 2023
Left ventricular systolic dysfunctionPhase 3
BR
31 May 2023
Left ventricular systolic dysfunctionPhase 3
CA
31 May 2023
Left ventricular systolic dysfunctionPhase 3
DK
31 May 2023
Left ventricular systolic dysfunctionPhase 3
FI
31 May 2023
Left ventricular systolic dysfunctionPhase 3
FR
31 May 2023
Left ventricular systolic dysfunctionPhase 3
DE
31 May 2023
Left ventricular systolic dysfunctionPhase 3
IT
31 May 2023
Left ventricular systolic dysfunctionPhase 3
MY
31 May 2023
Left ventricular systolic dysfunctionPhase 3
MX
31 May 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
mfxdqpbiim(tshwmfweub) = icjrnacfab swiykfmcty (mqtcdbtdhe, 14.3 - 26.8)
-
01 Sep 2024
Not Applicable
-
-
Vericiguat initiation in patients with eGFR ≤ 30
qqxebvyndb(idqykstkyf) = klrecqking dyhmyngyqu (munyrkeszp )
-
31 Aug 2024
Vericiguat initiation in patients with eGFR > 30
qqxebvyndb(idqykstkyf) = lcqxluzfqm dyhmyngyqu (munyrkeszp )
Not Applicable
-
vdieajqlfg(njngvpkoiw) = dklhrbbhjw bkgvtvzmgc (wcyzfbajeo, 1.05)
-
13 May 2024
Not Applicable
-
dbteeeghmk(vgdumaxfmk) = fugnflapgt tnbarcxyxp (tqhkjaeewn )
-
13 May 2024
Not Applicable
-
-
(VERITA registry)
vkulbdmuyf(ykmggjzhrt) = ookwveeemj avibhglfkh (ldlyebexba )
-
12 May 2024
(VICTORIA trial)
vkulbdmuyf(ykmggjzhrt) = qiytpyafrx avibhglfkh (ldlyebexba )
Not Applicable
200
nxbkqrgyxd(gbwoshkfin) = wgzrldmtcs sleqituibg (ljtjjazdkm )
Positive
12 May 2024
Not Applicable
-
-
asckkdksju(hbhqusmflf) = dxrsbkvnbm kvlzzbdzlh (ewmjuswifd )
-
12 May 2024
Optimized guideline-directed optimal medical therapy
asckkdksju(hbhqusmflf) = pnzqykadvq kvlzzbdzlh (ewmjuswifd )
Not Applicable
-
-
(Women)
yoblgnnwkf(mupdwkczew) = fmekiaqbiv vrgxhbyzfx (rsnfggubcv )
-
12 May 2024
yoblgnnwkf(mupdwkczew) = gxyrzocfii vrgxhbyzfx (rsnfggubcv )
Not Applicable
776
mfrzcnumtf(yxnehbldcr) = btwtvcbwsy zquxhqlqxl (lgppqobjrl, 7.7)
Positive
11 May 2024
Phase 3
Heart Failure | Heart failure with reduced ejection fraction
N-terminal pro-B-type natriuretic peptide levels
4,050
vpmguxgblc(amzpfjaurm) = qekxnxtihv jvuswqhvhg (fcbqvlaiic )
Negative
22 Jan 2024
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Approval

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Regulation

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