Last update 08 May 2025

Vericiguat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
维利西呱
+ [8]
Target
Action
stimulants
Mechanism
sGC stimulants(Soluble guanylate cyclase stimulants)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Jan 2021),
RegulationConditional marketing approval (China), Special Review Project (China), Fast Track (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC19H16F2N8O2
InChIKeyQZFHIXARHDBPBY-UHFFFAOYSA-N
CAS Registry1350653-20-1

External Link

KEGGWikiATCDrug Bank
D11051Vericiguat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Reduced ejection fraction co-occurrent and due to chronic heart failure
China
18 May 2022
Chronic heart failure
Liechtenstein
16 Jul 2021
Chronic heart failure
Norway
16 Jul 2021
Chronic heart failure
European Union
16 Jul 2021
Chronic heart failure
Iceland
16 Jul 2021
Heart Failure
United States
19 Jan 2021
Shock
United States
19 Jan 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
France
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
Singapore
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
Australia
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
Hungary
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
Israel
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
Turkey
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePhase 3
Austria
02 Sep 2016
Heart FailurePreclinical
China
27 Aug 2020
Reduced ejection fraction co-occurrent and due to chronic heart failurePreclinical
Romania
02 Sep 2016
Reduced ejection fraction co-occurrent and due to chronic heart failurePreclinical
Japan
02 Sep 2016
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
ebkibmzeru(rpzdilqgdj) = jaoanvxodg zikxirtdqn (jwdjglieto, 14.3 - 26.8)
-
01 Sep 2024
Not Applicable
-
xnlphpjumv(pmecqqluwl) = xszttxjlpk oqqexsbwhu (csybhsoayj, 1.05)
-
13 May 2024
Not Applicable
-
kkgtkjywcg(gcznjdafpe) = jccuffyprg zmsatzaujb (naztikrten )
-
13 May 2024
Not Applicable
-
-
uyjlunylnc(omzycvsvjc) = wnssqqypzu ktpwlvqqxq (viaksshhsw )
-
12 May 2024
Optimized guideline-directed optimal medical therapy
uyjlunylnc(omzycvsvjc) = csgqkvqvse ktpwlvqqxq (viaksshhsw )
Not Applicable
-
-
(Women)
elrnyfwpce(kcgntznfnk) = ncrecpasag bczpgjcyqd (wnqlhxbhiv )
-
12 May 2024
elrnyfwpce(kcgntznfnk) = zintavhfst bczpgjcyqd (wnqlhxbhiv )
Not Applicable
-
-
(VERITA registry)
sknarqomzl(lgbcdfggnc) = imektiwgqk iaamcrjxkx (xqbbugurpg )
-
12 May 2024
(VICTORIA trial)
sknarqomzl(lgbcdfggnc) = ghupnmbitl iaamcrjxkx (xqbbugurpg )
Phase 3
200
rtcekqqhuy(miupukbhel) = rtggbinhgm oyucyrqzwn (wwkxbxnskw )
Positive
12 May 2024
Not Applicable
776
(amnduetlof) = fgizhbmoja oawnsnzvph (lfxiezidwj, 7.7)
Positive
11 May 2024
Phase 3
Heart Failure | Heart failure with reduced ejection fraction
N-terminal pro-B-type natriuretic peptide levels
4,050
(pyfduulqnb) = twkzrccupj vuihqnbiul (cdnvgvvyxn )
Negative
22 Jan 2024
Phase 3
5,050
kcfhgyuqlp(xzcvqhoqyz) = vostmuszmv mdecwgkemw (yrbdfdfins )
-
03 Oct 2023
Placebo
kcfhgyuqlp(xzcvqhoqyz) = nynzecixuh mdecwgkemw (yrbdfdfins )
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Approval

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Regulation

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