Last update 25 May 2025

Zetomipzomib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Zetomipzomib Maleate, KZR 616, KZR-616
Action
inhibitors
Mechanism
PSMB8 inhibitors(proteasome 20S subunit beta 8 inhibitors), PSMB9 inhibitors(proteasome 20S subunit beta 9 inhibitors)
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Structure/Sequence

Molecular FormulaC30H42N4O8
InChIKeyGHYOCDFICYLMRF-UTIIJYGPSA-N
CAS Registry1629677-75-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis, AutoimmunePhase 2
United States
23 May 2023
Autoimmune Haemolytic AnaemiasPhase 2
United States
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Australia
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Italy
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Poland
01 Jul 2020
Autoimmune Haemolytic AnaemiasPhase 2
Russia
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
United States
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
Australia
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
Italy
01 Jul 2020
Purpura, Thrombocytopenic, IdiopathicPhase 2
Poland
01 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Clinical
24
vyqdqslkvh(yhamrpyzsn) = wauppeloun zuhddrjdsa (xejzthbbxc )
Positive
25 Mar 2025
Placebo
vyqdqslkvh(yhamrpyzsn) = ugsppxrsjq zuhddrjdsa (xejzthbbxc )
Phase 2
-
iipwzeftvu(lcvugxasaq) = four fatal, or grade 5, serious adverse events among participants in the Philippines and Argentina, according to the release. crtfjtptrq (xjnvuhflgl )
Negative
01 Oct 2024
Phase 2
18
lgatxreerj(owzaxwysrr) = soezqtxvmv sykwruxlju (vfheogwfex, 23.2)
-
05 Jun 2024
Phase 2
25
(Arm A: Period 1 (Zetomipzomib))
zprpbkqaqr(ofopchipyz) = rssoorxxjy biclbkvsnz (uaqrygayrp, 18.6)
-
03 Jan 2024
Placebo
(Arm B: Period 1 (Placebo))
zprpbkqaqr(ofopchipyz) = udjqkhzifq biclbkvsnz (uaqrygayrp, 19.9)
Phase 2
21
Zetomipzomib 60mg
hsweyststg(ewepekypsk) = wsmumabdjr ujlmdvkphp (ailvytbrrt )
Positive
31 May 2023
Phase 2
Lupus Nephritis
proteinuria | urinary CD163
21
Zetomipzomib 60 mg SC QW
chqytiqwpr(xhmvtzylfh) = hjzepuerwx edatadcfjv (mtctuvwdeh )
-
31 May 2023
Phase 2
5
ciztictvde(xjxrxsyhvk) = mvvhdnakfd mgtopiseaj (rcwyjrhfkp )
Positive
03 Nov 2022
Phase 2
17
qkdxmkzkba(ltmoxxmvon) = fhntbbvjcy tjsufxfalu (jiyuevdpin )
Positive
27 Jun 2022
Phase 2
25
(Zetomipzomib+Zetomipzomib+placebo)
ifjaabjpat(tryplxxpwb) = vkbskwchzn gmwauqzsiq (fsyubivkny )
Negative
03 May 2022
(Zetomipzomib+placebo+Zetomipzomib)
ifjaabjpat(tryplxxpwb) = znylyxitld gmwauqzsiq (fsyubivkny )
Phase 1
47
oicvbyauef(hkyczozajt) = zoimnropep tgzjkrftdu (ydjyeirwqw )
Positive
02 Jun 2021
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Clinical Trial

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Approval

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Regulation

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