Drug Type T-lymphocyte cell therapy |
Synonyms allogeneic T cells genetically modified with a retroviral vector encoding for a truncated form of the human low affinity nerve growth factor receptor (ΔLNGFR) and the herpes simplex I virus thymidine kinase (HSV-TK Mut2), Herpes simplex virus thymidine kinase (HSV-Tk) donor lymphocytes, HSV-Tk + [5] |
Target- |
Action stimulants |
Mechanism Cell replacements, Immunostimulants |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseWithdrawn |
First Approval Date European Union (18 Aug 2016), |
Regulation- |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hematologic Neoplasms | European Union | 18 Aug 2016 | |
Hematologic Neoplasms | Iceland | 18 Aug 2016 | |
Hematologic Neoplasms | Liechtenstein | 18 Aug 2016 | |
Hematologic Neoplasms | Norway | 18 Aug 2016 | |
Hematopoietic stem cell transplantation | European Union | 18 Aug 2016 | |
Hematopoietic stem cell transplantation | Iceland | 18 Aug 2016 | |
Hematopoietic stem cell transplantation | Liechtenstein | 18 Aug 2016 | |
Hematopoietic stem cell transplantation | Norway | 18 Aug 2016 |
Phase 2 | - | TK-DLI | yiqllqgnbm(kctsjwieyb) = chgatnryhr sgnwxvrqqy (nbinxevfhh ) View more | - | 20 Jun 2006 | ||
Not Applicable | 8 | Tk-DLI | kmwkoghqow(xxhtmamvwa) = Multiple doses of ganciclovir (10 mg/kg/die), in the absence of immunosuppressive drugs, quickly resulted in the complete resolution of all signs of GvHD nhhoudmgyn (lzvquntexw ) View more | - | 15 Jul 2004 | ||
Not Applicable | 8 | sjhpbfsird(unmpewqwef) = 1/8 patients experienced grade II biopsy-proven acute GvHD, involving the skin and the liver. The administration of multiple doses of ganciclovir (10 mg/kg/die), in the absence of immunosuppressive drugs, quickly resulted in the complete resolution of all clinical and biochemical signs of GvHD. Two patients of this series received unmodified DLI and died of refractory GvHD and disease progression. xsfzabwahy (ltvartiblu ) | Positive | 01 May 2002 |