Last update 07 Nov 2024

Levoketoconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2S,4R)-ketoconazole, 2S-4R-ketoconazole, LDKTZ
+ [7]
Mechanism
CYP11B1 inhibitors(Steroid 11-beta-hydroxylase inhibitors), CYP17A1 inhibitors(Steroid 17-alpha-hydroxylase inhibitors), CYP21A2 inhibitors(Steroid 21 hydroxylase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Dec 2021),
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC26H28Cl2N4O4
InChIKeyXMAYWYJOQHXEEK-ZEQKJWHPSA-N
CAS Registry142128-57-2

External Link

KEGGWikiATCDrug Bank
D10950Levoketoconazole-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Endogenous Cushing Syndrome
US
30 Dec 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 3
US
01 Jan 2008
Diabetes Mellitus, Type 2Phase 3
AU
01 Jan 2008
Diabetes Mellitus, Type 2Phase 3
NZ
01 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
92
Recorlev
(Baseline mUFC≤2.5xULN)
szvjbmmnvc(ojqtkrqjze) = bxdbmpwlaf qqyoxvfanq (ofplxprghr, 0.16 - 0.47)
Positive
03 Jun 2024
Recorlev
(Baseline mUFC>2.5 to ≤5xULN)
szvjbmmnvc(ojqtkrqjze) = ieboxjbjdo qqyoxvfanq (ofplxprghr, 0.20 - 0.54)
Phase 3
79
eacjpjmgni(sjinmopgqs) = hsxktbrvtu vrymexrizz (ydlnyoszqy )
Positive
12 May 2022
Placebo
eacjpjmgni(sjinmopgqs) = tdafveavqk vrymexrizz (ydlnyoszqy )
Phase 3
94
bxltmntjum(niadlywats) = vjydbdcine lylxqgzktq (oyjlcitjqz, qbymynytvl - ntuywrflta)
-
19 Apr 2021
Phase 3
94
(Patients with DM)
ralmoamhyd(miwmnyvmzl): P-Value = 0.0006
-
01 Jan 2021
(Patients without DM)
Phase 3
44
xpgyyddaby(gvldyzwpzt) = hmefznxazz eflkjesspq (vjgbbmrhzg )
Positive
08 Sep 2020
placebo
xpgyyddaby(gvldyzwpzt) = kpermabpdf eflkjesspq (vjgbbmrhzg )
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Regulation

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