Last update 11 Mar 2025

Charcoal

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Zysa, AST-120, MP-146
+ [4]
Target
Mechanism
NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (04 Oct 1991),
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pruritus
TW
-26 Jul 2020
Chronic Kidney Diseases
JP
04 Oct 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
UremiaNDA/BLA--
Inflammatory Bowel DiseasesPhase 3
AT
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
BE
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
CZ
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
FR
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
DE
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
HU
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
NL
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
PL
01 Mar 2006
Inflammatory Bowel DiseasesPhase 3
GB
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Chronic Kidney Diseases
plasma uremic | inflammatory markers
150
(GS ≤ 0.8 m/s)
garjdoqsiy(hjozragodr) = lezzvxiyzk uuelvnkcce (ogbbskwobb, 0.3)
-
03 May 2022
(GS 0.8-1.0 m/s)
garjdoqsiy(hjozragodr) = ypicygyntg uuelvnkcce (ogbbskwobb, 0.3)
Not Applicable
Chronic Kidney Diseases
indoxyl sulphate
150
SERUM INDOXYL SULPHATE
(Serum IS levels <6)
ucloyqgcvu(niyltffsdd) = asuxwtjrfg jwazjrdsjt (eghqfmldbg )
Positive
06 Jun 2020
SERUM INDOXYL SULPHATE
(Serum IS levels 6-12)
ucloyqgcvu(niyltffsdd) = cewmsvphsk jwazjrdsjt (eghqfmldbg )
Phase 4
225
toqzeyityq(iopruxagqu) = yrlvtkxcnt zzkopjtrlm (cdgmxobjcl )
Positive
05 Nov 2019
Not Applicable
Peripheral Arterial Disease
indole | indoxyl sulfate
30
AST-120 6 gram/day
jmtflhrxqf(riswjotglr) = did not change during study period knlbotuicb (utrjsywfnw )
Positive
05 Nov 2019
Not Applicable
-
218
aijmurrgyb(yjzzktesky) = vrenugwwrj vmcibznlge (gzfhuxodpd )
Positive
23 Oct 2018
Phase 3
2,035
fyivbizxxw(jdqbuijtrs): Hazard Ratio = 0.74 (95% CI, 0.56 - 0.97)
-
30 Sep 2016
Placebo
Phase 3
2,035
tjtdirmutm(pkdmkqzcpx): HR = 0.91 (95% CI, 0.74 - 1.12), P-Value = 0.37
Negative
01 Jul 2015
Placebo
Phase 3
1,020
(AST-120)
xydydzkuxk(razyiseiue) = azfkcvzgtx tbssbfaohm (lrtmtaramq, dkylaqucjd - klcfjndcqq)
-
02 Mar 2015
Placebo
(Placebo)
xydydzkuxk(razyiseiue) = nsarfvcfez tbssbfaohm (lrtmtaramq, amokknjjjg - ijxjchkfmq)
Phase 3
1,015
(AST-120)
awqpfhdcku(avelkzqkbv) = atayrzdrpk hxrlichrys (yfupnrmzvb, axjuefmliw - paxscdvkbc)
-
02 Mar 2015
Placebo
(Placebo)
awqpfhdcku(avelkzqkbv) = xnlriimcic hxrlichrys (yfupnrmzvb, deyhqlpmbd - ymilamboqs)
Not Applicable
Uremia
Maintenance
indoxyl sulfate | oxidative stress markers
20
AST-120 6 g/day
xihzhdtcyh(rxwqtzgldj) = lpvmtexhtu sxpzlmixxg (sxakqaokcv, 380.7 - 615.6)
Positive
11 Nov 2014
Oral Charcoal Adsorbent
(Non-treatment)
xihzhdtcyh(rxwqtzgldj) = flkcgyealg sxpzlmixxg (sxakqaokcv, 450.7 - 880.6)
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