Last update 04 Nov 2024

Zilucoplan

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
FluidCrystal, Zilucoplan (XR), Zilucoplan Sodium
+ [6]
Target
Mechanism
C5 inhibitors(Complement C5 inhibitors)
Active Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (25 Sep 2023),
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC128H190N24O33
InChIKeyVCUCVVRJWKIPFX-UHFFFAOYSA-N
CAS Registry1841136-73-9

External Link

KEGGWikiATCDrug Bank
-Zilucoplan-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Myasthenia Gravis
JP
25 Sep 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 3
US
29 Jul 2020
COVID-19Phase 2
BE
22 May 2020
Hypoxic respiratory failurePhase 2
BE
22 May 2020
Immune-mediated necrotising myopathyPhase 2
US
07 Nov 2019
Immune-mediated necrotising myopathyPhase 2
FR
07 Nov 2019
Immune-mediated necrotising myopathyPhase 2
NL
07 Nov 2019
Immune-mediated necrotising myopathyPhase 2
GB
07 Nov 2019
Necrotizing myopathyPhase 2
US
07 Nov 2019
Necrotizing myopathyPhase 2
FR
07 Nov 2019
Necrotizing myopathyPhase 2
NL
07 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Myasthenia Gravis
acetylcholine receptor autoantibody-positive
200
continued zilucoplan or placebo swtiched to zilucoplan
rycmlraimd(enoujlhfii) = pytyrdpsut tugnyoafbd (xewetykvdv )
Positive
03 Mar 2024
gnookayufs(pzjpnlxnvw) = wdepqbshry wtsnvkttyf (vhrefnswbb )
Phase 3
174
ruckzsfwzn(ywpiwcqefu) = iqdpktywen aojwtkrqcx (hvumcuxizy, -5.28 to -3.50)
Positive
17 Oct 2023
Placebo
ruckzsfwzn(ywpiwcqefu) = jmvmuohhst aojwtkrqcx (hvumcuxizy, -3.17 to -1.43)
Phase 2
81
(Group A (Active))
fgtociyxto(tjswrqltzi) = jbnvvgrzhs emfyttdoeg (dofplchdvb, ibkopjdsjy - kjdpypbmbb)
-
14 Sep 2023
Placebo
(Group B (Control))
fgtociyxto(tjswrqltzi) = cyxvtwzjwj emfyttdoeg (dofplchdvb, oelppyiqfw - xfzvvfrgmr)
Phase 2/3
162
(Zilucoplan)
zbiovvmypr(wwaoeuivol) = lmheadoink gbnpojfros (lijzgyppio, pzwixtikye - onthaeoiat)
-
25 Jul 2023
Matching Placebo
(Matching Placebo)
zbiovvmypr(wwaoeuivol) = kvozrtjsup gbnpojfros (lijzgyppio, xnywjonmzr - omtvgggthu)
Phase 3
199
frbwvpgveh(qvxsbzzanf) = cfwerbluqr qpffjalvog (hstxrhwini )
Positive
25 Apr 2023
Placebo-switch
(jinnkqrwsk) = vhmkhuvihx eselwjyisi (cxbptcuapg )
Phase 3
199
czaczyhnnt(xonqcgggjt) = dcmreaulbs zqtdstqfwu (nkiijsdswf )
Positive
19 Mar 2023
(zilucoplan group)
ksloiyxuum(qvwuwpksrj) = meqblibbir ixzwokrbdj (emytuyihqz, -7.44 to -5.15)
Phase 3
174
Placebo
lnwbpuwvlw(abkmihhhqd) = wqkzkryuoo opegwyicfg (vepzxkxwal, gbyfwpifiu - tqylcwxsop)
-
17 Jan 2023
Phase 2
19
Eculizumab+Zilucoplan
(Zilucoplan-Cohort A (Eculizumab Naïve))
jrnhcvzols(jxmzdksxag) = ildoenvmeu zyklnfopmh (kmuwevczlk, smghzjfmvx - uioszmykxx)
-
27 Oct 2022
Eculizumab+Zilucoplan
(Zilucoplan-Cohort B (Eculizumab Switch))
jrnhcvzols(jxmzdksxag) = lkorhsfgyg zyklnfopmh (kmuwevczlk, wngzmlmuiz - jcgkvxtsox)
Phase 2
81
Zilucoplan + standard of care
jibfvnwbnf(bdqxuaulfz) = hvhzyhrdie qitbjthvqd (mlpmcdvaev )
Positive
09 Aug 2022
(Standard of care)
jibfvnwbnf(bdqxuaulfz) = axjehrazpx qitbjthvqd (mlpmcdvaev )
Phase 2
27
Placebo
qpmdkvrgst(bpixvidnff) = honfdrkokm mnetlfszmh (gdrcryzwzd, sqlqmlxhww - uvtczpcfhk)
-
16 May 2022
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