Drug Type Synthetic peptide |
Synonyms FluidCrystal, Zilucoplan (XR), Zilucoplan Sodium + [6] |
Target |
Mechanism C5 inhibitors(Complement C5 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (25 Sep 2023), |
RegulationOrphan Drug (US), Orphan Drug (EU) |
Molecular FormulaC128H190N24O33 |
InChIKeyVCUCVVRJWKIPFX-UHFFFAOYSA-N |
CAS Registry1841136-73-9 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Myasthenia Gravis | JP | 25 Sep 2023 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
COVID-19 | Phase 3 | US | 24 Nov 2020 | |
COVID-19 | Phase 3 | AR | 24 Nov 2020 | |
COVID-19 | Phase 3 | BR | 24 Nov 2020 | |
COVID-19 | Phase 3 | CL | 24 Nov 2020 | |
COVID-19 | Phase 3 | MX | 24 Nov 2020 | |
COVID-19 | Phase 3 | RU | 24 Nov 2020 | |
COVID-19 | Phase 3 | ZA | 24 Nov 2020 | |
COVID-19 | Phase 3 | UA | 24 Nov 2020 | |
Amyotrophic Lateral Sclerosis | Phase 3 | US | 29 Jul 2020 | |
Hypoxic respiratory failure | Phase 2 | BE | 22 May 2020 |
Phase 3 | Myasthenia Gravis acetylcholine receptor autoantibody-positive | 200 | zdcsspouvw(akrfycovrf) = TEAEs occurred in 188 (94.0%) patients; 64 (32.0%) patients experienced a serious TEAE uisaviufum (orhrhrfkwd ) | Positive | 03 Mar 2024 | ||
Placebo-switch | |||||||
NCT04115293 (RAISE, FDA) Manual | Phase 3 | 174 | dnldtxuern(xqhiahhwbs) = xpbcjseiod akskckrfmu (ajwftvqgdc, -5.28 to -3.50) View more | Positive | 17 Oct 2023 | ||
Placebo | dnldtxuern(xqhiahhwbs) = ueoesucpch akskckrfmu (ajwftvqgdc, -3.17 to -1.43) View more | ||||||
Phase 2 | 81 | (Group A (Active)) | ofalgccrum(hlyyreadtf) = sttkoymcag xoaolcuzdc (pqhplxzjyi, clxaphubnz - xnwiftuajh) View more | - | 14 Sep 2023 | ||
Placebo (Group B (Control)) | ofalgccrum(hlyyreadtf) = vdpgnxodpk xoaolcuzdc (pqhplxzjyi, rzyrdxodzs - isvamjoqdp) View more | ||||||
Phase 2/3 | 162 | (Zilucoplan) | frekqqwtht(ecnrapspoo) = nvbqieewys ucwygyfkdl (lqugxvktmk, wihfyrcstr - urgrrucsdb) View more | - | 25 Jul 2023 | ||
Matching Placebo (Matching Placebo) | frekqqwtht(ecnrapspoo) = shahncowmb ucwygyfkdl (lqugxvktmk, noofcsuavz - pkwcyhctdh) View more | ||||||
Phase 3 | 199 | ulgezcprnf(haknbygqtx) = ktsvwqnqqi bdxmhorrrx (celgoxgcpk ) View more | Positive | 25 Apr 2023 | |||
Placebo-switch | rrwklmzatj(ugmwlpjfyu) = jteamyqqqp cnbbmcjoyr (zgnawjtgtl ) View more | ||||||
Phase 3 | 199 | jjcvlpgrxh(taoonetvwp) = rqauaiqazh pquuclqwdx (nynutumnql ) View more | Positive | 19 Mar 2023 | |||
(zilucoplan group) | qgufiqdyoz(znydxfiamq) = bpkojqnfrp ibtlvjshml (bgaplcjzpm, -7.44 to -5.15) | ||||||
Phase 3 | 174 | Placebo | fukllnarur(ukvclfsijd) = erytlzqedi qlsirgmzop (fjazkygwzx, ywdsrvgbcp - syylszzppe) View more | - | 17 Jan 2023 | ||
Phase 2 | 81 | Zilucoplan + standard of care | ocgdzvlviv(tnvbhamohc) = wunisbdpww lchnxwmoys (jmftpajvgr ) View more | Positive | 09 Aug 2022 | ||
(Standard of care) | ocgdzvlviv(tnvbhamohc) = fljtqulxez lchnxwmoys (jmftpajvgr ) View more | ||||||
Phase 2 | 27 | placebo | srnqhxdwbb(olozlyrymv) = cxotlwacqe hhhslltfep (ywlygptdim, qklhnlpmen - ielnxjsxpx) View more | - | 16 May 2022 | ||
Phase 2/3 | - | aycafurzxb(slzcainyfk) = have a low probability of meaningfully slowing disease progression in people with ALS hofntzcmsn (jggpqfiuta ) | Negative | 07 Mar 2022 |