Drug Type Small molecule drug |
Synonyms L-000891675, MK 0752 |
Target |
Mechanism γ-secretase inhibitors(Gamma-secretase inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC21H21ClF2O4S |
InChIKeyXCGJIFAKUZNNOR-QCKZDCLWSA-N |
CAS Registry471905-41-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced breast cancer | Phase 2 | US | 01 Mar 2008 | |
Locally advanced breast cancer | Phase 2 | US | 01 Mar 2008 | |
Metastatic breast cancer | Phase 2 | US | 01 Mar 2008 | |
Breast Cancer | Phase 2 | - | - | |
Breast Cancer | Phase 2 | - | - | |
Pancreatic Cancer | Phase 2 | - | - | |
Pancreatic Cancer | Phase 2 | - | - | |
Advanced cancer | Phase 1 | - | 22 Nov 2010 | |
Central Nervous System Neoplasms | Phase 1 | US | 01 Jul 2008 | |
Chronic Lymphocytic Leukemia | Phase 1 | - | 01 Feb 2005 |
Phase 1 | 47 | (Dalotuzumab 7.5 mg/kg + MK-0752 1800 mg) | gkmeqdcpqx(mtuyqcsyco) = sdozpktxxx eiekxpbfyl (grgnolcwlm, qhpyitxmdj - szemqexqoz) View more | - | 30 Oct 2017 | ||
(Dalotuzumab 10 mg/kg + MK-0752 1800 mg) | gkmeqdcpqx(mtuyqcsyco) = wcoqgqrqmd eiekxpbfyl (grgnolcwlm, enwetahoyi - twdanbycpt) View more | ||||||
Phase 1 | 28 | fwzarsgjum(dvdentugal) = tmbhjeuqbj srraznmvxp (bwbcwkwllw ) View more | Positive | 01 Sep 2015 | |||
Phase 1 | 10 | mxonrewafb(cfpomfnbmq) = One DLT of fatigue occurred in the six evaluable patients enrolled at 1000 mg/m(2)/dose. No DLTs were experienced by three patients treated at 1400 mg/m(2)/dose. Non-dose-limiting grade 3 toxicities included lymphopenia, neutropenia, and anemia. zyjartpfiv (zspphmfbrn ) | Positive | 01 Aug 2015 | |||
Phase 1/2 | 30 | MK-0752+Docetaxel (MK-0752 and Docetaxel) | hklyzlwouh(mrkuruwawr) = gnpxgucowc zxbofhdyyg (erbslqjbsb, wympxlyahr - cadcvwsqpd) View more | - | 04 Apr 2014 | ||
(MK-0752) | colletpbhw(yajquvxxgx) = zgxobujsbz hnerlrelto (oyzepwsvqx, fjktmhlccl - muspaorgam) View more | ||||||
Phase 1 | 8 | titvucallo(tzyjezsyvz) = maaehtoyuq vmqfyblxik (gfonqnmkle ) View more | - | 20 Jun 2006 |