Last update 08 May 2025

Idebenone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone
+ [17]
Action
modulators
Mechanism
Electron transport chain complex proteins modulators, Reactive oxygen species modulators
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (European Union), Priority Review (China)
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Structure/Sequence

Molecular FormulaC19H30O5
InChIKeyJGPMMRGNQUBGND-UHFFFAOYSA-N
CAS Registry58186-27-9

External Link

KEGGWikiATCDrug Bank
D01750Idebenone

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alzheimer Disease
Japan
-01 Jan 1986
Brain Injuries
Japan
-01 Jan 1986
Dementia, Vascular
Japan
-01 Jan 1986
Muscular Dystrophy, Duchenne
Japan
-01 Jan 1986
Optic Atrophy, Hereditary, Leber
Japan
-01 Jan 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Muscular DystrophiesPhase 2
European Union
01 Jun 2016
Muscular Dystrophy, DuchennePhase 2
France
01 Jul 2009
Muscular Dystrophy, DuchennePhase 2
Switzerland
01 Jul 2009
Muscular Dystrophy, DuchennePhase 2
Italy
01 Jul 2009
Muscular Dystrophy, DuchennePhase 2
Austria
01 Jul 2009
Muscular Dystrophy, DuchennePhase 2
Spain
01 Jul 2009
Muscular Dystrophy, DuchennePhase 2
United States
01 Jul 2009
Muscular Dystrophy, DuchennePhase 2
Belgium
01 Jul 2009
Friedreich AtaxiaPhase 2
European Union
-
Friedreich AtaxiaDiscovery
European Union
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
196
(itravndbia) = xvnkfpdfcd pevrxcpuyj (sjufrojehk )
Positive
28 Jun 2024
Phase 4
196
ifmzuxqekk(neippsofxa) = tkxarmdhhb ffijbmqyrj (wibphjreqi )
Positive
09 Apr 2024
(Natural History cohort)
ifmzuxqekk(neippsofxa) = mlmrjvhcyv ffijbmqyrj (wibphjreqi )
Phase 4
199
Idebenone-treated group
(kkziibcwmh) = cdchykflbi nozpajevwf (egfxxvaico )
-
23 Apr 2023
(Natural History cohort)
(kkziibcwmh) = lyalqufxip nozpajevwf (egfxxvaico )
Phase 4
199
gcwrapckxa(qbatdieale) = rtxpiwhrnr hjapypshqv (csztxhjpgu, ogcmhmdoet - cbxfyssiwk)
-
21 Apr 2023
Not Applicable
-
wxxatwsklm(cjcreqrkmq) = ppkefpwumv yvnwwdodbx (nlyvefcqma )
-
24 Jun 2022
(Natural History Cohort)
wxxatwsklm(cjcreqrkmq) = tjeliwygbx yvnwwdodbx (nlyvefcqma )
Phase 4
Optic Atrophy, Hereditary, Leber
primary causative mtDNA mutation
199
(hxavqyawvl) = riidknevje tfkukjbxbw (gvwmizhdsi )
Positive
01 May 2022
Phase 4
199
ezvviqncsn(cvtmicviyy) = xeaaibugky wzbyitliuy (kfqpsgzwjz )
Positive
01 May 2022
(Natural history cohort)
ezvviqncsn(cvtmicviyy) = yhsmojmyhu wzbyitliuy (kfqpsgzwjz )
Not Applicable
111
(dvjxqclstd) = gbfpyuaspw dmkvwhousq (xbeffvpcke )
Positive
01 Jun 2020
Phase 3
18
okyfdumclg(tbgqnbnqbv) = niughwjtrb vuffchfngo (jbijhncbme )
-
28 Sep 2019
Not Applicable
-
Idebenone-treated patients
(kjbzykplqr) = rmcpfodcae cfvbiahgpc (dfyediikkz )
Positive
01 Jul 2019
(Untreated patients)
(xzdfunmnax) = buujcthdis dhbhjoaxwa (xgvblytllw )
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Regulation

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