Last update 31 May 2025

Tegoprazan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
K-CAB, 特戈拉赞, BLI-5100
+ [7]
Action-
Mechanism
P-CAB(Potassium-competitive acid blockers)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC20H19F2N3O3
InChIKeyCLIQCDHNPDMGSL-HNNXBMFYSA-N
CAS Registry942195-55-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Duodenal Ulcer
China
14 Nov 2023
Esophagitis, Peptic
China
08 Apr 2022
Gastroesophageal Reflux
South Korea
05 Jul 2018
Helicobacter pylori infection
South Korea
05 Jul 2018
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stomach UlcerPhase 3
United States
01 May 2016
Non-erosive gastro-esophageal reflux diseasePhase 3
United States
22 Sep 2015
Non-erosive reflux diseasePhase 3
United States
22 Sep 2015
Erosive esophagitisPhase 3
United States
01 May 2015
Liver InjuryPhase 1
United States
08 Sep 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
6
Tegoprazan 50 mg/150 μCi
hfqtwpitvr(aqzzmimjln) = wusjtcofhj suhiuvmzec (tmfslciojt )
-
13 May 2025
Not Applicable
-
-
Tegoprazan 50mg
meskftqsep(bfrqnkuszw) = No significant differences in the incidence of adverse events between the trial group and the placebo group. No severe adverse events occurred in this study. kqkhcrpoqx (orvywtbkge )
-
13 Oct 2024
Placebo
Not Applicable
80
Tegoprazan-based BQT
hirrnnicxi(iltoyvgssl) = There was no significant difference in the rate of adverse events between the TBMT and OBMT groups (42.5% vs. 55,5%, p = 0.37). Nausea was the most common adverse effect (37.5% vs 40%, p=0.92) , followed by abdominal pain (12.5% vs 17.5%, p=0.16%) cyfazcusuo (whgqemyygu )
Positive
13 Oct 2024
Not Applicable
-
-
Esomeprazole-containing sequential therapy
pqdryprmlz(gfzmkajfjl) = In tegoprazan-containing sequential, nausea was more prevalent (23.3%, 27/202), which was statistically higher than esomeprazole-containing sequential (14.2%, 29/204) (p = 0.022) xwbcenxfwk (xctcbxqdfb )
-
13 Oct 2024
Tegoprazan-containing sequential therapy
Phase 3
399
cgtpdjbwjm(hyuomnhlel) = bgmatgztdd tnkjzvumjs (hpwzwfqhva )
Non-inferior
08 Oct 2024
cgtpdjbwjm(hyuomnhlel) = nmmtgyibxx tnkjzvumjs (hpwzwfqhva )
Not Applicable
406
Esomeprazole-containing sequential therapy
hfpfylmypg(urhtgmpppu) = Nausea was more prevalent (23.3%, 27/202) with sequential tegoprazans than with esomeprazole-containing sequential therapy (14.2%, 29/204; p = 0.022) kiqwwpdqij (tucwzcrqhr )
Positive
01 Sep 2024
Tegoprazan-containing sequential therapy
Phase 3
555
gviabwilpm(xpilhetgsg) = lregdicqtw chtthfcige (pkmesbatmo )
Positive
21 May 2024
艾司奥美拉唑
gviabwilpm(xpilhetgsg) = cccnbinfvr chtthfcige (pkmesbatmo )
Not Applicable
-
612
uyymjxynza(afbmzqoovh) = lemixvmavm mlmkursbfa (yczotmooxs )
Positive
21 May 2024
PPI
uyymjxynza(afbmzqoovh) = fyznamopvf mlmkursbfa (yczotmooxs )
Not Applicable
-
-
vibcewwfyj(dmphrnfzik): RR = 1.17 (95% CI, 1.11 - 1.22)
-
18 May 2024
Conventional PPI-based triple therapy
Not Applicable
368
Tegoprazan-amoxicillin (TA)
yidhrbrynl(zdtunlakgd) = xgewoylbcj nakqscngdw (exhxwpbovb )
Positive
01 May 2024
Esomeprazole-amoxicillin (EA)
yidhrbrynl(zdtunlakgd) = mumymyozll nakqscngdw (exhxwpbovb )
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Clinical Trial

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Approval

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Regulation

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