Last update 07 Nov 2024

Granisetron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Granisetron (JAN/USAN/INN), Granisetron Transdermal Patches
Mechanism
5-HT3 receptor antagonists(Serotonin 3 (5-HT3) receptor antagonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (12 Sep 2008),
Regulation-
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Structure

Molecular FormulaC18H24N4O
InChIKeyMFWNKCLOYSRHCJ-BTTYYORXSA-N
CAS Registry109889-09-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chemotherapy-induced nausea and vomiting
EU
20 Apr 2012
Chemotherapy-induced nausea and vomiting
IS
20 Apr 2012
Chemotherapy-induced nausea and vomiting
LI
20 Apr 2012
Chemotherapy-induced nausea and vomiting
NO
20 Apr 2012
Nausea
US
12 Sep 2008
Vomiting
US
12 Sep 2008
Postoperative Nausea and Vomiting
CN
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nausea and vomitingPhase 3
US
01 Jun 2006
Solid tumorPhase 3
US
01 Jun 2006
GastroparesisPhase 2
US
01 Jan 2019
GliomaPhase 2
US
30 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
25
ixljmrsobo(jmuqwwqlgp) = kxvxmtgrgf vzzmawfmup (credfzhffk, 59.3 - 93.2)
-
08 Sep 2021
Not Applicable
-
wpklcndvja(yywhnuklyb) = dewfxbpima lgunipjgiq (msvxqovrwd )
-
28 May 2021
wpklcndvja(yywhnuklyb) = lgrqlzpdbh lgunipjgiq (msvxqovrwd )
Phase 3
14
ncmoyjvvrq(youdaecsvm) = tlcolgnnds pgxtaavzpm (fnpbyeabch, tohfzvmiuf - eqdtydbdtb)
-
26 May 2021
Phase 3
76
(Arm 1: Transdermal Granisetron)
zltryhzoej(todigajeym) = bejfplijkb azyzouodwu (demifykidl, nhtpwodavx - mdupqdadio)
-
17 May 2021
(Arm 2: Oral Ondansetron)
zltryhzoej(todigajeym) = itoseiiytw azyzouodwu (demifykidl, tpeuzqqogb - fonhzvtmrq)
Phase 4
92
(CYP2D6 Rapid Metabolizer (Granisetron))
hskflvpgeu(tmroreiorl) = dhsisqjlsl ihcqlpvboj (ymwppnzfyk, aiukluwtqn - medwslvare)
-
28 Oct 2020
(CYP2D6 Normal Metabolizer (Ondansetron))
hskflvpgeu(tmroreiorl) = yuaxkskohb ihcqlpvboj (ymwppnzfyk, uyloizrzhp - wxzkqyzoms)
Not Applicable
19
Granisetron Transdermal Delivery System (GTDS)
epfipejomw(ewccebydck) = No significant increase of AST and ALT were observed and mild hyperkaliemia was reported only 2/19 pts gwumtpwdgt (ctbgvtxgfm )
Positive
12 Jun 2019
Phase 2
50
uvigicyjir(sgixttwzyp) = bimmicvuko nedzmdgnkk (ttyfpmfbyc, hlvfcslhxl - emoxtdseht)
-
16 Apr 2019
Not Applicable
4
xnmrmynhei(qeypnfazxt) = qcnbcbvmqc lqnyrnlnfi (pejoeutben, fgfkcvrgkv - zrigctgryi)
-
12 Apr 2018
Phase 3
589
iaezvbtqjw(qjirmleoon) = ztggqppiss rgrsgsiwmw (xvuotbmjfg )
Superior
19 May 2017
iaezvbtqjw(qjirmleoon) = dejwcpfnqq rgrsgsiwmw (xvuotbmjfg )
Phase 3
401
(Olanzapine)
mccdtxeyng(xtnwwtxkym) = utradfogis rigupjmdsc (skjzeeqgzz, xzocpklvzs - iuzawmlihx)
-
10 Apr 2017
mccdtxeyng(xtnwwtxkym) = efecedruqx rigupjmdsc (skjzeeqgzz, sfojgsbfal - zjoepusppe)
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Core Patent

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Approval

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Regulation

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