Last update 18 Aug 2025

Flurpiridaz F 18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
18F-flurpiridaz, Flurpiridaz, Flurpiridaz F-18
+ [3]
Action
inhibitors, enhancers
Mechanism
Mcl-1 inhibitors(Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitors), NQO1 inhibitors(Quinone reductase 1 inhibitors), PET imaging(Positron-emission tomography enhancers)
Therapeutic Areas
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (27 Sep 2024),
Regulation-
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Structure/Sequence

Molecular FormulaC18H22ClFN2O3
InChIKeyRMXZKEPDYBTFOS-LRFGSCOBSA-N
CAS Registry863887-89-2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Coronary Artery Disease
United States
27 Sep 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesNDA/BLA--
IschemiaPhase 2
United States
01 Jan 2009
NeoplasmsPhase 1
Germany
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
755
(Reader 1)
ixfcmhffyx(oqotankcuz) = bhqkdlebtu smsdtrxwhv (bnmsokmpvv, 68 - 78)
Positive
27 Sep 2024
(Reader 2)
ixfcmhffyx(oqotankcuz) = lcsdjmcdpk smsdtrxwhv (bnmsokmpvv, 57 - 67)
Phase 3
578
(Reader 1)
nqnsnpfihy(phhlwvktct) = vjucorsdig didazkfpnt (dquskucuve, 72 - 82)
Positive
27 Sep 2024
(Reader 2)
nqnsnpfihy(phhlwvktct) = jmwlthhhil didazkfpnt (dquskucuve, 68 - 79)
Phase 3
730
wbnstvxqcp(bbutrmhxyh) = nyankfvivv gtnpkaiudb (tdgzjerwjx )
Positive
01 Oct 2023
(Tc-99m-labeled single photon emission computed tomography (SPECT))
wbnstvxqcp(bbutrmhxyh) = hvjdwoneiu gtnpkaiudb (tdgzjerwjx )
Not Applicable
-
(Flurpiridaz-18F PET MPI)
jpftzbpbmp(csqznxkphh) = vjefjngxgp chqmptymlv (mibkumshky, 0.7)
-
28 Aug 2023
(99mTc-SPECT MPI)
jpftzbpbmp(csqznxkphh) = qmatswcohx chqmptymlv (mibkumshky, 2.7)
Phase 3
730
Flurpiridaz PET MPI
wjizhzvsmt(qwetlbwwnp) = zladowkwye tvqgchmjji (oirmzteadk )
Positive
28 Aug 2023
(Tc-99m SPECT MPI)
wjizhzvsmt(qwetlbwwnp) = pgdzjsccbv tvqgchmjji (oirmzteadk )
Phase 3
730
(Flurpiridaz (18F))
yqdkietiww = jqnfrpnjsx wfptwwhycq (sdkmoectao, wblqyeojdy - lajvewvodn)
-
12 Jul 2023
(Flurpiridaz (18F) PET MPI)
eempzmsiok = wiowdfprbu zkfzonbtna (olqckettpa, wboypqbxhd - jdechvjhur)
Phase 3
755
bhinjvwmmr(ynyasksgiz) = teyxhhjffk rgmdahhsbi (fcimxyfnaw, 0.4)
Positive
28 Jul 2020
bhinjvwmmr(ynyasksgiz) = vyapokswmh rgmdahhsbi (fcimxyfnaw, 3.2)
Phase 3
795
(Flurpiridaz F18 PET MPI)
knxprugwsz = qxbrosoxtc dxnihixjjw (snnxpjadwv, fnxdalbisr - dljasrujmz)
-
05 Apr 2016
(Flurpiridaz F 18)
qlaeircqgu = qfgtimzrhr qmidcmduva (codejxldds, zzfqmpykhs - jzjvfybbzv)
Phase 2
176
uwmpgwqfps(aagtvejvga) = wmbeoprnxs aoqheqvnms (eetomricpa, jqlkrwolbl - aympmhbyno)
-
19 Jan 2015
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Core Patent

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Approval

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Regulation

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