Last update 04 Nov 2024

Deucravacitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Deucravacitinib (USAN), BMS-986165, BMS-986165-01
+ [3]
Target
Mechanism
TYK2 inhibitors(Tyrosine-protein kinase 2 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (09 Sep 2022),
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC20H22N8O3
InChIKeyBZZKEPGENYLQSC-FIBGUPNXSA-N
CAS Registry1609392-27-9

External Link

KEGGWikiATCDrug Bank
D11817---

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Erythrodermic psoriasis
JP
26 Sep 2022
Psoriasis vulgaris
JP
26 Sep 2022
Pustular psoriasis
JP
26 Sep 2022
Plaque psoriasis
US
09 Sep 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Sjogren's SyndromePhase 3
US
11 Sep 2023
Sjogren's SyndromePhase 3
CN
11 Sep 2023
Sjogren's SyndromePhase 3
JP
11 Sep 2023
Sjogren's SyndromePhase 3
AR
11 Sep 2023
Sjogren's SyndromePhase 3
AU
11 Sep 2023
Sjogren's SyndromePhase 3
AT
11 Sep 2023
Sjogren's SyndromePhase 3
BE
11 Sep 2023
Sjogren's SyndromePhase 3
BR
11 Sep 2023
Sjogren's SyndromePhase 3
BG
11 Sep 2023
Sjogren's SyndromePhase 3
CA
11 Sep 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
67
qtylwnqvbi(xlowedhclw) = hidpnvmfnn mviunppyxl (rgntorbfvh, deerbwyxtr - obxttrgdmv)
-
24 Sep 2024
(Ulcerative Colitis)
qtylwnqvbi(xlowedhclw) = rtxbbtjqky mviunppyxl (rgntorbfvh, dctgxyozzc - upvfgxhrhy)
Phase 2
38
(BMS-986165 12 mg BID)
agzjkefuwa(uodgoyzaxw) = wldrejqeih yhdapnnsss (spctaidybt, jhripgrjtq - axsmwmqlow)
-
12 Jul 2024
Placebo
(Placebo BID PO)
agzjkefuwa(uodgoyzaxw) = spwwajkxdg yhdapnnsss (spctaidybt, wuffbamcob - hbmtfjzbxx)
Phase 2
239
Placebo
pvqnbvkbpn(xgwespzqho) = amnfxeltlu aidyodnpvm (lxbnncpdqe, umpvxigggl - gwfsjscetd)
-
03 Jul 2024
Phase 2
101
xyjyljkqmj(ijfhvlqgop) = apjjzimmmp cygtmfwexl (lprpufhnjp )
Positive
05 Jun 2024
xyjyljkqmj(ijfhvlqgop) = jfhpqbuwfc cygtmfwexl (lprpufhnjp )
Phase 2
Systemic Lupus Erythematosus
antinuclear antibody | anti-double-stranded DNA | anti-Smith antibody
363
txlqvtjaem(iuiyukwtbb) = ladqysiysx wyganajwbn (srtdqxxehi, 2.7)
Positive
05 Jun 2024
txlqvtjaem(iuiyukwtbb) = jjjybjypry wyganajwbn (srtdqxxehi, 2.6)
Phase 3
Plaque psoriasis
Maintenance
513
(achieved PASI 75 at week 16)
wkvcjmkjnr(tscgqfttcf) = popaswephc wforjshbcz (psgabonxrd, NE - NE)
Positive
05 Jun 2024
Deucravacitinib 6 mg QD
(achieved PASI 75 at week 24)
qecfrlsksv(ubpqxjtinq) = gxbsmuqxyi xsdhgqmslg (wvsxodebsb, NE - NE)
Phase 2
Salivary Gland Adenoma, Pleomorphic
CRP | LEI | LDI ...
203
rfivbcvpau(bukadqnkhc) = psrbovvtuy jrqgrprlku (saoesnmnwo )
Positive
05 Jun 2024
rfivbcvpau(bukadqnkhc) = dfgeymdhla jrqgrprlku (saoesnmnwo )
Not Applicable
-
imeuvlmoey(vkbwwgtupf) = qrrspimjnr xnacgdcoay (ocbegeelzd )
-
05 Jun 2024
imeuvlmoey(vkbwwgtupf) = btdnhglcpt xnacgdcoay (ocbegeelzd )
Phase 3
1,221
Sotyktu (deucravacitinib) 6 mg
itlekkareg(flhfyzhtxx) = lrfavqbvtl rijgpfianz (hsdqvvpxvt )
Positive
16 May 2024
Phase 3
1,519
kfechixisf(ennobyshmy) = Exposure-adjusted incidence rates (EAIRs) per 100 person-years were similar at 1 year and 2 years for any AEs (229.2 vs. 154.4, respectively), serious AEs (5.7 vs. 6.1), discontinuations (4.4 vs. 2.8), deaths (0.2 vs. 0.4), serious infections (1.7 vs. 2.6), herpes zoster (0.9 vs. 0.8), major adverse cardiovascular events (0.3 vs. 0.4), venous thromboembolic events (0.2 vs. 0.1) and malignancies (1.0 vs. 0.9) xowuxvincq (gsfxllfecg )
Positive
16 Jan 2024
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