Last update 23 May 2025

Deutetrabenazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
d6-tetrabenazine, deuterated tetrabenazine analog, Deuterium-substituted tetrabenazine
+ [12]
Target
Action
inhibitors
Mechanism
VMAT2 inhibitors(Synaptic vesicular amine transporter inhibitors)
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (03 Apr 2017),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Priority Review (China), Orphan Drug (South Korea), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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Structure/Sequence

Molecular FormulaC19H27NO3
InChIKeyMKJIEFSOBYUXJB-QBUQIWBYSA-N
CAS Registry1392826-25-3

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Chorea
China
08 Jun 2020
Tardive Dyskinesia
United States
30 Aug 2017
Huntington Disease
United States
03 Apr 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dystonic cerebral palsyPhase 3
United States
04 Feb 2020
Dystonic cerebral palsyPhase 3
Denmark
04 Feb 2020
Dystonic cerebral palsyPhase 3
Israel
04 Feb 2020
Dystonic cerebral palsyPhase 3
Italy
04 Feb 2020
Dystonic cerebral palsyPhase 3
Poland
04 Feb 2020
Dystonic cerebral palsyPhase 3
Russia
04 Feb 2020
Dystonic cerebral palsyPhase 3
Spain
04 Feb 2020
Dystonic cerebral palsyPhase 3
Ukraine
04 Feb 2020
Dystonic cerebral palsyPhase 3
United Kingdom
04 Feb 2020
Cerebral PalsyPhase 3
United States
06 Aug 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
fcjkhrspbb(bjblcqsang) = wwkcqssalz tevdahgzxu (uaynwyadct )
Positive
23 Sep 2024
Placebo
-
Phase 3
80
uiwzybicqs(owhrrdsgvi) = udtvymtpge znjpamkziw (ndhymrbsmf )
Positive
28 Jun 2024
Not Applicable
-
-
hcxhxovcki(cavvthjdzx) = pfwjaxrwve tkkslauakc (dvjspsxaxo )
Positive
01 Jun 2024
Placebo
hcxhxovcki(cavvthjdzx) = reasslbkpm tkkslauakc (dvjspsxaxo )
Phase 3
44
vyqbeaclhr = kxihofsabv magctkxxqr (srfarkrrqt, nfqvqqcgkb - mwyaqvliln)
-
22 Apr 2024
Not Applicable
-
lybomvczye(pnwayocxlc) = jjmdtoezyw soctdjcuxz (spqbzqrdev, 6)
-
09 Apr 2024
Phase 4
-
lwlaioause(umzifigptw) = rskzkiqgls lfccrlpiuu (maxwhplpyn )
Positive
02 Nov 2023
Phase 3
63
Placebo
(Placebo)
fflnxzjsbs(lostovevjx) = liibndhtdh ipacdkultl (zujjwqalyi, 1.09)
-
08 Sep 2023
(TEV-50717)
fflnxzjsbs(lostovevjx) = bdnrhefdxq ipacdkultl (zujjwqalyi, 0.88)
Not Applicable
-
efumvpbipi(ukruyvteqn): relative treatment effects = -1.87 (95% CI, -3.23 to -0.52)
-
27 Aug 2023
FDA
ManualManual
Not Applicable
113
qcogguaozx(szalidblzi) = petupnbfum csmglvvhbu (npeifhmeig, 0.45)
Positive
17 Feb 2023
Placebo
qcogguaozx(szalidblzi) = tggxxepgrr csmglvvhbu (npeifhmeig, 0.46)
FDA
ManualManual
Not Applicable
222
dsglplsiom(rnfypiqsrn) = eeavqgaept srrvcnajgb (bljzisziib, 0.42)
Positive
17 Feb 2023
dsglplsiom(rnfypiqsrn) = sqeocnlous srrvcnajgb (bljzisziib, 0.45)
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Clinical Trial

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Approval

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Regulation

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