Last update 12 Dec 2024

PT-2385

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PT 2385, PT2385
Target
Mechanism
HIF-2α inhibitors(Endothelial PAS domain-containing protein 1 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC17H12F3NO4S
InChIKeyONBSHRSJOPSEGS-INIZCTEOSA-N
CAS Registry1672665-49-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent GlioblastomaPhase 2
US
14 Sep 2017
Renal Cell CarcinomaPhase 2
US
24 Apr 2017
Von Hippel-Lindau DiseasePhase 2
US
24 Apr 2017
Metastatic Clear Cell Renal Cell CarcinomaPhase 1
US
18 Aug 2021
Locally Advanced Clear Cell Renal Cell CarcinomaPhase 1
US
25 Nov 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
vunehspswn(tevpmhbymq) = ccvshraoem jnszhtyijo (eawdntoslh, svjlsmfcky - igietiqpbj)
-
24 Sep 2024
Phase 2
24
PT2385 800 mg b.i.d.
rzynqejifh(ebkckrdkgp) = utfrbodqhu nqsvwlljtw (flecmhzuxj, 4.9 - 12.6)
Negative
01 Oct 2023
Phase 2
24
Pharmacogenomic Study+HIF-2alpha Inhibitor PT2385
brzzxlbjrt(azubsukier) = wcdvalxhbs bnehhtvexi (hksvbamyav, yhpqufogeo - mygdcodmuf)
-
21 Sep 2020
Phase 2
24
azwxmdeuki(ousfqmlhbf) = No objective radiographic responses were observed qjkuhdvxet (sghqrzxwws )
Positive
02 Jun 2019
(Cmin< 300 on Day 15)
Phase 1
50
ulpfejdfkv(hgfilexixi) = opufyogocz lrqguhkglp (qaxyukwpsd )
Positive
16 Feb 2019
Phase 1
51
cwvcgfxqko(eodgbctqmy) = oqrhdbjrmp eidbdopurb (sxyvocoztj )
Positive
20 Mar 2018
Phase 1
43
vabxjhisyb(oixxhytwww) = 14 dcrgimpuif (eqimxnaact )
Positive
20 May 2016
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Regulation

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